Results 21 to 30 of about 4,070 (143)

Airway inflammation patterns and clinical and functional features in patients with severe uncontrolled asthma and cold-induced airway hyperresponsiveness

PULMONOLOGIYA, 2017
The aim of this study was to investigate airway inflammation patterns and clinical and functional features of severe uncontrolled asthma.Methods. The study involved 25 patients aged 45 to 55 years with severe uncontrolled asthma. Medical history was analyzed.
A. B. Pirogov, V. P. Kolosov, Yu. M. Perel'man, A. G. Prikhod'ko, S. V. Zinov'ev, D. A. Gassan, T. A. Mal'tseva   +6 more
openaire   +2 more sources

Interaction of tumor necrosis factor-alpha and interferon-gamma with bronchial phagocytic cells in non-allergic bronchial asthma patients

Сибирский научный медицинский журнал
The contribution of immunoregulatory cytokines to the formation of cold airway hyperresponsiveness in asthma patients is important for understanding approaches to therapy. Aim of the study was to investigate the interaction of tumor necrosis factor-alpha
A. B. Pirogov, A. G. Prihodko, N. A. Pirogova, Ju. M. Perelman   +3 more
doaj   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

THE CHANGE OF GOBLET CELLS IN RESPONSE TO COLD BRONCHIAL CHALLENGE IN PATIENTS WITH BRONCHIAL ASTHMA WITH COLD AIRWAY HYPERRESPONSIVENESS

Bulletin physiology and pathology of respiration, 2018
Destruction of bronchial epithelium in patients with bronchial asthma (BA) is at the bottom of the mechanism of epithelial dysfunction, mucociliary insufficiency and bronchial remodeling. The aim of the work is to assess the character of changes that happen in the structural organization of cell elements and secretory activity of bronchial goblet ...
Ci Li, Xiangdong Chzhou, Sergey Zinovev, Yuliy Perelman, Anna Prikhodko, Aleksey Pirogov   +5 more
openaire   +2 more sources

Resveratrol Ameliorates Allergic Rhinitis by Activating SIRT1 to Disrupt the Mitochondrial ROS‐Inflammation Vicious Cycle

Flavour and Fragrance Journal, EarlyView.
This study demonstrates that resveratrol alleviates allergic rhinitis by activating SIRT1, thereby disrupting the mitochondrial ROS‐inflammatory cycle, improving mitochondrial function, promoting anti‐inflammatory M2 macrophage polarisation, and reducing epithelial oxidative damage.
Xinyu Zhou, Yi Yue, Wenwen Qi, Wenqing Zhu, Xinran Liu, Rongcui Sui, Xuanchen Zhou   +6 more
wiley   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, EarlyView.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Glucocorticoid‐Induced TNFR‐Related Ligand as a Biomarker for Diagnosis and Severity of Asthma in Children

Pediatric Discovery, EarlyView.
Our study demonstrates elevated GITRL expression in HDM‐exposed dendritic cells (in vitro), murine asthma models, and pediatric asthma patients, and reveals a direct association between GITRL levels and disease severity in children. ABSTRACT Currently, there are no reliable pediatric biomarkers for assessing the severity of asthma. Therefore, the study
Yuehan Li, Yan Li, Jinying Xiang, Yinying Ren, Mi Zhou, Fang Deng, Zhou Fu, Fengxia Ding   +7 more
wiley   +1 more source

Evidence‐based guideline for clinical practice in the diagnosis, treatment, management, and prevention of recurrent wheezing in infants and toddlers in China

Pediatric Investigation, EarlyView.
ABSTRACT Wheezing is a common respiratory symptom in infants and toddlers, and recurrent wheezing is a significant respiratory disorder affecting this age group. Given the multifactorial etiology of recurrent wheezing, clinical practice lacks standardized diagnostic and therapeutic protocols. Recent years have witnessed substantial progress in clinical
Committee of Pediatrics, China Medical Education Association, Cooperative Group of Asthma, the Subspecialty Group of Respiratory, the Society of Pediatrics, Chinese Medical Association, Pediatric Respiratory Work Committee, Society of Pulmonologists, Chinese Medical Doctor Association, Committee of Pediatrics, Chinese Research Hospital Association, Pediatric Professional Committee of the Chinese Non‐public Medical Institutions Association, Professional Committee of Children's Health and Pharmaceutical Research, China Association of Traditional Chinese Medicine, Children's Safe Medication Branch of China News of Drug Information Association, Pediatric Expert Committee of China Primary Health Care Foundation, China International Medical Foundation   +16 more
wiley   +1 more source

Research Progress on Upper Airway Cough Syndrome

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
wiley   +1 more source

FEATURES OF STRUCTURAL ORGANIZATION OF GOBLET EPITHELIUM OF BRONCHI IN ASTHMA PATIENTS WITH COLD AIRWAY HYPERRESPONSIVENESS

Bulletin physiology and pathology of respiration, 2018
In 46 patients with mild persistent asthma the collection and cytological study of the induced sputum (IS) was done to assess the inflammatory pattern of bronchi, structural organization of bronchial epithelium and secretory goblet cells; the level of the disease control by the data of the validated questionnaire Asthma Control Test was found out; the ...
Ci Li, Xiangdong Chzhou, Yuliy Perelman, Anna Prikhodko, Sergey Zinovev, Aleksey Pirogov   +5 more
openaire   +2 more sources