Results 41 to 50 of about 60,419 (262)

Limits on spin-dependent WIMP-proton cross-sections using the DRIFT-IId directional dark matter detector [PDF]

, 2011
The nature of dark matter remains one of the biggest questions in physics today. Weakly Interacting Massive Particles (WIMPs) are a particularly well motivated candidate for the missing matter that makes up 85% of the mass of the Universe.
Pipe, Mark
core  

Particle motion and QPOs around Euler-Heisenberg black hole immersed in cold dark matter halo

Nuclear Physics B
We explore the motion of particles in the vicinity of an Euler-Heisenberg black hole immersed in a cold dark matter halo, focusing on how the black hole parameters influence particle dynamics. This black hole solution is characterized by five parameters,
G. Mustafa, S.K. Maurya, Tayyab Naseer, Arzu Cilli, Ertan Güdekli, Assmaa Abd-Elmonem, Neissrien Alhubieshi   +6 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Nine Rings of the Galaxy LEDA 1313424

The Astrophysical Journal
The galaxy LEDA 1313424 has recently been discovered by I. Pasha et al. to have nine rings. The authors of the discovery paper interpret the rings to be the result of the passing of a smaller galaxy through the center of the LEDA galaxy 56 Myr ago.
Pierre Sikivie, Yuxin Zhao
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Cold dark matter plus not-so-clumpy dark relics

, 2017
Various particle physics models suggest that, besides the (nearly) cold dark matter that accounts for current observations, additional but sub-dominant dark relics might exist. These could be warm, hot, or even contribute as dark radiation.
Roberta Diamanti, Diamanti, R., Weniger, C., Shin'ichiro Ando, Gariazzo, S., Christoph Weniger, Olga Mena, Ando, S.; id_orcid, Stefano Gariazzo, Mena, O.   +9 more
core   +1 more source

The DREAMS Project: Disentangling the Impact of Halo-to-halo Variance and Baryonic Feedback on Milky Way Dark Matter Density Profiles

The Astrophysical Journal
In this work, we utilize a new suite of Milky Way–mass halos from the DREAMS Project, simulated with cold dark matter (CDM), to quantify the influence of baryon feedback and intrinsic halo-to-halo variance on dark matter density profiles.
Alex M. Garcia, Jonah C. Rose, Paul Torrey, Andrea Caputo, Mariangela Lisanti, Andrew B. Pace, Hongwan Liu, Abdelaziz Hussein, Haozhe Liu, Francisco Villaescusa-Navarro, John Barry, Ilem Leisher, Belén Costanza, Jonathan Kho, Ethan Lilie, Jiaxuan Li, Niusha Ahvazi, Aklant Bhowmick, Tri Nguyen, Stephanie O’Neil, Xiaowei Ou, Xuejian Shen, Arya Farahi, Nitya Kallivayalil, Lina Necib, Mark Vogelsberger   +25 more
doaj   +1 more source

Strongly-interacting ultralight millicharged particles

Physics Letters B, 2021
We consider the implications of an ultra-light fermionic dark matter candidate that carries baryon number. This naturally arises if dark matter has a small charge under standard model baryon number whilst having an asymmetry equal and opposite to that in
Stephon Alexander, Evan McDonough, David N. Spergel   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Dark matter in galaxy clusters in the context of LCDM and MOND [PDF]

, 2023
openThe nature of dark matter remains one of the most significant unsolved mysteries in the field of physics. The observations that lead to the dark matter problem are reviewed in Chapter 1 of this thesis.
KELLEHER, RUTH
core