Results 41 to 50 of about 53,221 (261)

C-19 and Hot, Wide Star Streams

The Astrophysical Journal
The C-19 star stream has the abundance characteristics of an unusually metal-poor globular cluster but kinematically is uncharacteristically hot and wide for a cluster stream, having a line-of-sight velocity dispersion of 7  ±  2 km s ^−1 and a 1 σ width
Raymond G. Carlberg, Rodrigo Ibata, Nicolas F. Martin, Else Starkenburg, David S. Aguado, Khyati Malhan, Kim Venn, Zhen Yuan   +7 more
doaj   +1 more source

Observational constraints on variable equation of state parameters of dark matter and dark energy after Planck

Physics Letters B, 2014
In this paper, we study a cosmological model in general relativity within the framework of spatially flat Friedmann–Robertson–Walker space–time filled with ordinary matter (baryonic), radiation, dark matter and dark energy, where the latter two ...
Suresh Kumar, Lixin Xu
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The fate of substructures in cold dark matter haloes [PDF]

Monthly Notices of the Royal Astronomical Society, 2009
14 pages, 11 figures.
Angulo, R.E., Lacey, C.G., Baugh, C.M., Frenk, C.S.   +3 more
openaire   +4 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Scalar dark matter and cold stars [PDF]

Astroparticle Physics, 2006
In a medium composed of scalar particles with non-zero mass, the range of Van-der-Waals-type scalar mediated interactions among nucleons becomes infinite when the medium makes a transition to a Bose-Einstein condensed phase. We explore this phenomenon in an astrophysical context.
openaire   +2 more sources

Indirect Detection of Decaying Dark Matter with High Angular Resolution: The Case for Axion Search by IRCS on the Subaru Telescope

The Astrophysical Journal
Recent advances in photon detectors have provided exceptional sensitivities to dark matter with high angular resolution. Motivated by this, we present a detailed study of photon flux from dark matter decay in dwarf spheroidal galaxies (dSphs) by focusing
Wen Yin, Kohei Hayashi
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Electroweak loop contributions to the direct detection of wino dark matter

European Physical Journal C: Particles and Fields
Electroweak loop corrections to the matrix elements for the spin-independent scattering of cold dark matter particles on nuclei are generally small, typically below the uncertainty in the local density of cold dark matter. However, as shown in this paper,
John Ellis, Natsumi Nagata, Keith A. Olive, Jiaming Zheng   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source