Results 41 to 50 of about 53,858 (261)
Constraints on anharmonic corrections of fuzzy dark matter
Journal of High Energy Physics, 2018 The cold dark matter (CDM) scenario has proved successful in cosmology. However, we lack a fundamental understanding of its microscopic nature. Moreover, the apparent disagreement between CDM predictions and subgalactic-structure observations has ...
J. A. R. Cembranos +3 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Assessment of Dark Matter Models Using Dark Matter Correlations across Dwarf Spheroidal Galaxies
Universe, 2022 The predicted size of dark matter substructures in kilo-parsec scales is model-dependent. Therefore, if the correlations between dark matter mass densities as a function of the distances between them are measured via observations, we can scrutinize dark ...
Ahmad Borzou
doaj +1 more source
The fate of substructures in cold dark matter haloes [PDF]
Monthly Notices of the Royal Astronomical Society, 2009 14 pages, 11 figures.
Angulo, R.E. +3 more
openaire +4 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
C-19 and Hot, Wide Star Streams
The Astrophysical JournalThe C-19 star stream has the abundance characteristics of an unusually metal-poor globular cluster but kinematically is uncharacteristically hot and wide for a cluster stream, having a line-of-sight velocity dispersion of 7 ± 2 km s ^−1 and a 1 σ width
Raymond G. Carlberg +7 more
doaj +1 more source
Physics Letters B, 2014 In this paper, we study a cosmological model in general relativity within the framework of spatially flat Friedmann–Robertson–Walker space–time filled with ordinary matter (baryonic), radiation, dark matter and dark energy, where the latter two ...
Suresh Kumar, Lixin Xu
doaj +1 more source
Microlensing and Halo Cold Dark Matter
Physical Review Letters, 1995 We discuss the implications of the more than 50 microlensing events seen by the EROS, MACHO, and OGLE collaborations for the composition of the halo of our galaxy. The event rates indicate that the halo mass fraction in MACHO's is less than 30\%, consistent with expectations for a universe whose primary component is cold dark matter.
Gates, Evalyn I. +2 more
openaire +3 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source