Results 51 to 60 of about 60,419 (262)

The DREAMS Project: Disentangling the Impact of Halo-to-Halo Variance and Baryonic Feedback on Milky Way Dark Matter Speed Distributions

The Astrophysical Journal
Dark matter direct detection experiments require information about the local dark matter speed distribution to produce constraints on dark matter candidates, or infer their properties in the event of a discovery.
Ethan Lilie, Jonah C. Rose, Mariangela Lisanti, Alex M. Garcia, Paul Torrey, Kassidy E. Kollmann, Jiaxuan Li, Olivia Mostow, Bonny Y. Wang, Stephanie O’Neil, Xuejian Shen, Alyson M. Brooks, Arya Farahi, Nitya Kallivayalil, Lina Necib, Andrew B. Pace, Mark Vogelsberger   +16 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Exploring Dark Matter’s Nature from Local Galactic Dynamics to High-z JWST Observations

, 2023
The Cold Dark Matter paradigm emerged as the prevailing solution to the cosmic missing mass conundrum. While highly successful on cosmological scales, this model is partially inconsistent with galaxy-scale observations.
GANDOLFI, GIOVANNI
core  

The Signatures of Self-interacting Dark Matter and Subhalo Disruption on Cluster Substructure

The Astrophysical Journal, 2022
The abundance, distribution, and inner structure of satellites of galaxy clusters can be sensitive probes of the properties of dark matter. We run 30 cosmological zoom-in simulations with self-interacting dark matter (SIDM), with a velocity-dependent ...
Joy Bhattacharyya, Susmita Adhikari, Arka Banerjee, Surhud More, Amit Kumar, Ethan O. Nadler, Suchetana Chatterjee   +6 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

WISPy Cold Dark Matter

, 2011
Very weakly interacting slim particles (WISPs), such as axion-like particles (ALPs) or hidden photons (HPs), may be non-thermally produced via the misalignment mechanism in the early universe and survive as a cold dark matter population until today.
Davide Cadamuro, Javier Redondo, Joerg Jaeckel, Ringwald, A., Cadamuro, D., Redondo, J., Redondo, Javier, Jaeckel, Joerg, Paola Arias, Jaeckel, J., Andreas Ringwald, Cadamuro, Davide, Goodsell, M., Goodsell, Mark, Mark Goodsell, Ringwald, Andreas, Arias, Paola, Arias, P.   +17 more
core   +1 more source

What X-rays tell us about dark matter halos

, 2004
We present a detailed non-spherical modeling of dark matter halos on the basis of a careful analysis of state-of-the art N-body simulations. The fitting formulae presented here form a complete and accurate description of the triaxial density profiles of ...
Ryder, SD, Jing, YP, Freeman, KC, Pisano, DJ, Walker, MA   +4 more
core   +1 more source

The Stellar Distribution in Ultrafaint Dwarf Galaxies Suggests Deviations from the Collisionless Cold Dark Matter Paradigm

The Astrophysical Journal Letters
Unraveling the nature of dark matter (DM) stands as a primary objective in modern physics. Here we present evidence suggesting deviations from the collisionless cold DM (CDM) paradigm.
Jorge Sánchez Almeida, Ignacio Trujillo, Angel R. Plastino   +2 more
doaj   +1 more source

Remnants of Galactic Subhalos and Their Impact on Indirect Dark-Matter Searches

Galaxies, 2019
Dark-matter subhalos, predicted in large numbers in the cold-dark-matter scenario, should have an impact on dark-matter-particle searches. Recent results show that tidal disruption of these objects in computer simulations is overefficient due to ...
Martin Stref, Thomas Lacroix, Julien Lavalle   +2 more
doaj   +1 more source