Results 51 to 60 of about 55,316 (261)
Assessment of Dark Matter Models Using Dark Matter Correlations across Dwarf Spheroidal Galaxies
Universe, 2022 The predicted size of dark matter substructures in kilo-parsec scales is model-dependent. Therefore, if the correlations between dark matter mass densities as a function of the distances between them are measured via observations, we can scrutinize dark ...
Ahmad Borzou
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Astrophysical JournalIn this pilot study, we investigate whether intracluster light (ICL) can serve as an observational discriminator of dark matter physics. The self-interacting dark matter (SIDM) model has gained increasing attention as a possible resolution to small-scale
Jaewon Yoo +7 more
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Physics Letters B, 2014 In this paper, we study a cosmological model in general relativity within the framework of spatially flat Friedmann–Robertson–Walker space–time filled with ordinary matter (baryonic), radiation, dark matter and dark energy, where the latter two ...
Suresh Kumar, Lixin Xu
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To Observe, or Not to Observe, Quantum-Coherent Dark Matter in the Milky Way, That is a Question
Frontiers in Astronomy and Space Sciences, 2021 In recent years, Bose-Einstein-condensed dark matter (BEC-DM) has become a popular alternative to standard, collisionless cold dark matter (CDM). This BEC-DM -also called scalar field dark matter (SFDM)- can suppress structure formation and thereby ...
Tanja Rindler-Daller
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Electroweak loop contributions to the direct detection of wino dark matter
European Physical Journal C: Particles and FieldsElectroweak loop corrections to the matrix elements for the spin-independent scattering of cold dark matter particles on nuclei are generally small, typically below the uncertainty in the local density of cold dark matter. However, as shown in this paper,
John Ellis +3 more
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Status of cold dark matter cosmology [PDF]
Nuclear Physics B - Proceedings Supplements, 2003 10 pages, for Proceedings of 5th International UCLA Symposium on Sources and Detection of Dark Matter, Marina del Rey, February 2002, ed.
openaire +2 more sources
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source