Results 31 to 40 of about 60,419 (262)

Unified Dark Matter scalar field models with fast transition

, 2011
We investigate the general properties of Unified Dark Matter (UDM) scalar field models with Lagrangians with a non-canonical kinetic term, looking specifically for models that can produce a fast transition between an early Einstein-de Sitter CDM-like era
Bertacca, Daniele, Piattella, Oliver F., Davide Pietrobon, Bruni, Marco, Oliver F Piattella, Piattella, O., Pietrobon, Davide, Marco Bruni, PIATTELLA O, Daniele Bertacca   +9 more
core   +1 more source

C-19 and Hot, Wide Star Streams

The Astrophysical Journal
The C-19 star stream has the abundance characteristics of an unusually metal-poor globular cluster but kinematically is uncharacteristically hot and wide for a cluster stream, having a line-of-sight velocity dispersion of 7  ±  2 km s ^−1 and a 1 σ width
Raymond G. Carlberg, Rodrigo Ibata, Nicolas F. Martin, Else Starkenburg, David S. Aguado, Khyati Malhan, Kim Venn, Zhen Yuan   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Clustering of Dark Matter, Haloes & Galaxies [PDF]

, 2008
In this thesis I study the spatial distribution of galaxies, haloes and dark matter particlesin the Universe. The subjects investigated are conceptually divided into three areas.One line of research, which is made up of Chapters 2 and 3， is to explore ...
Raúl Esteban Angulo de la Puente,
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Electroweak loop contributions to the direct detection of wino dark matter

European Physical Journal C: Particles and Fields
Electroweak loop corrections to the matrix elements for the spin-independent scattering of cold dark matter particles on nuclei are generally small, typically below the uncertainty in the local density of cold dark matter. However, as shown in this paper,
John Ellis, Natsumi Nagata, Keith A. Olive, Jiaming Zheng   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Warm little inflaton becomes cold dark matter [PDF]

, 2019
We present a model where the inflaton can naturally account for all the dark matter in the Universe within the warm inflation paradigm. In particular, we show that the symmetries of the Warm Little Inflaton scenario (i) avoid large thermal and radiative
Rosa, João Pedro Trancoso Gomes, Ventura, Luís Bastos   +1 more
core   +1 more source

Indirect Detection of Decaying Dark Matter with High Angular Resolution: The Case for Axion Search by IRCS on the Subaru Telescope

The Astrophysical Journal
Recent advances in photon detectors have provided exceptional sensitivities to dark matter with high angular resolution. Motivated by this, we present a detailed study of photon flux from dark matter decay in dwarf spheroidal galaxies (dSphs) by focusing
Wen Yin, Kohei Hayashi
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source