Results 61 to 70 of about 53,858 (261)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

The DREAMS Project: Disentangling the Impact of Halo-to-halo Variance and Baryonic Feedback on Milky Way Dark Matter Density Profiles

The Astrophysical Journal
In this work, we utilize a new suite of Milky Way–mass halos from the DREAMS Project, simulated with cold dark matter (CDM), to quantify the influence of baryon feedback and intrinsic halo-to-halo variance on dark matter density profiles.
Alex M. Garcia, Jonah C. Rose, Paul Torrey, Andrea Caputo, Mariangela Lisanti, Andrew B. Pace, Hongwan Liu, Abdelaziz Hussein, Haozhe Liu, Francisco Villaescusa-Navarro, John Barry, Ilem Leisher, Belén Costanza, Jonathan Kho, Ethan Lilie, Jiaxuan Li, Niusha Ahvazi, Aklant Bhowmick, Tri Nguyen, Stephanie O’Neil, Xiaowei Ou, Xuejian Shen, Arya Farahi, Nitya Kallivayalil, Lina Necib, Mark Vogelsberger   +25 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The DREAMS Project: Disentangling the Impact of Halo-to-Halo Variance and Baryonic Feedback on Milky Way Dark Matter Speed Distributions

The Astrophysical Journal
Dark matter direct detection experiments require information about the local dark matter speed distribution to produce constraints on dark matter candidates, or infer their properties in the event of a discovery.
Ethan Lilie, Jonah C. Rose, Mariangela Lisanti, Alex M. Garcia, Paul Torrey, Kassidy E. Kollmann, Jiaxuan Li, Olivia Mostow, Bonny Y. Wang, Stephanie O’Neil, Xuejian Shen, Alyson M. Brooks, Arya Farahi, Nitya Kallivayalil, Lina Necib, Andrew B. Pace, Mark Vogelsberger   +16 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Electrochemical Behavior of Flame‐Sprayed Sc‐Doped AlCoCrFeMo High‐Entropy Alloy Coatings in 3.5% Sodium Chloride Solution

Advanced Engineering Materials, EarlyView.
Scandium (Sc)‐doped AlCoCrFeMo HEA coatings are fabricated via flame spraying with 0.1, 0.3, and 0.5 wt% Sc additions. Among these, the HEA‐Sc0.3 coating exhibits the highest corrosion resistance, indicated by a more positive corrosion potential and lower current density.
Pankaj Kumar, Akash Vyas, Mohammad Aatif Qazi, Nashit Jalal, Maria Ophelia Jarligo, Mostafa Yakout, Jing Liu, André McDonald   +7 more
wiley   +1 more source

Scalar dark matter and cold stars [PDF]

Astroparticle Physics, 2006
In a medium composed of scalar particles with non-zero mass, the range of Van-der-Waals-type scalar mediated interactions among nucleons becomes infinite when the medium makes a transition to a Bose-Einstein condensed phase. We explore this phenomenon in an astrophysical context.
openaire   +2 more sources

Intermediate Resistive State in Wafer‐Scale Vertical MoS2 Memristors Through Lateral Silver Filament Growth for Artificial Synapse Applications

Advanced Functional Materials, EarlyView.
In MOCVD MoS2 memristors, a current compliance‐regulated Ag filament mechanism is revealed. The filament ruptures spontaneously during volatile switching, while subsequent growth proceeds vertically through the MoS2 layers and then laterally along the van der Waals gaps during nonvolatile switching.
Yuan Fa, Milan Buttberg, Ke Ran, Rana Walied Ahmad, Dennis Braun, Lukas Völkel, Jimin Lee, Sofía Cruces, Bart Macco, Bárbara Canto, Holger Lerch, Thorsten Wahlbrink, Holger Kalisch, Michael Heuken, Andrei Vescan, Joachim Mayer, Zhenxing Wang, Ilia Valov, Stephan Menzel, Max C. Lemme   +19 more
wiley   +1 more source

The Stellar Distribution in Ultrafaint Dwarf Galaxies Suggests Deviations from the Collisionless Cold Dark Matter Paradigm

The Astrophysical Journal Letters
Unraveling the nature of dark matter (DM) stands as a primary objective in modern physics. Here we present evidence suggesting deviations from the collisionless cold DM (CDM) paradigm.
Jorge Sánchez Almeida, Ignacio Trujillo, Angel R. Plastino   +2 more
doaj   +1 more source

The Signatures of Self-interacting Dark Matter and Subhalo Disruption on Cluster Substructure

The Astrophysical Journal, 2022
The abundance, distribution, and inner structure of satellites of galaxy clusters can be sensitive probes of the properties of dark matter. We run 30 cosmological zoom-in simulations with self-interacting dark matter (SIDM), with a velocity-dependent ...
Joy Bhattacharyya, Susmita Adhikari, Arka Banerjee, Surhud More, Amit Kumar, Ethan O. Nadler, Suchetana Chatterjee   +6 more
doaj   +1 more source