Results 81 to 90 of about 55,316 (261)

Remnants of Galactic Subhalos and Their Impact on Indirect Dark-Matter Searches

open access: yesGalaxies, 2019
Dark-matter subhalos, predicted in large numbers in the cold-dark-matter scenario, should have an impact on dark-matter-particle searches. Recent results show that tidal disruption of these objects in computer simulations is overefficient due to ...
Martin Stref   +2 more
doaj   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

open access: yesAdvanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao   +10 more
wiley   +1 more source

Self-interacting Dark Matter in the Center of a Local Group Dwarf Galaxy and Its Satellites

open access: yesThe Astrophysical Journal
We present a detailed comparison of a Local Group dwarf galaxy analogue evolved in two cosmological models: the standard cold dark matter (DM) and a self-interacting dark matter (SIDM) model with a velocity-dependent cross section.
Thales A. Gutcke   +5 more
doaj   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

open access: yesAdvanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee   +6 more
wiley   +1 more source

How Many Bursts Does It Take to Form a Core at the Center of a Galaxy?

open access: yesThe Astrophysical Journal
We present a novel method for systematically assessing the impact of the central potential fluctuations associated with bursty outflows on the structures of dark matter halos for classical and ultrafaint dwarf (UFD) galaxies.
Olivia Mostow   +6 more
doaj   +1 more source

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

open access: yesAdvanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão   +5 more
wiley   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

open access: yesAdvanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez   +8 more
wiley   +1 more source

Dark matter, sparticle spectroscopy and muon (g − 2) in SU(4) c × SU(2) L × SU(2) R

open access: yesJournal of High Energy Physics, 2018
We explore the sparticle mass spectra including LSP dark matter within the framework of supersymmetric SU(4) c × SU(2) L × SU(2) R (422) models, taking into account the constraints from extensive LHC and cold dark matter searches.
M. E. Gómez   +3 more
doaj   +1 more source

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