Results 91 to 100 of about 690,483 (329)

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Remnants of Galactic Subhalos and Their Impact on Indirect Dark-Matter Searches

Galaxies, 2019
Dark-matter subhalos, predicted in large numbers in the cold-dark-matter scenario, should have an impact on dark-matter-particle searches. Recent results show that tidal disruption of these objects in computer simulations is overefficient due to ...
Martin Stref, Thomas Lacroix, Julien Lavalle   +2 more
doaj   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

The Stellar Distribution in Ultrafaint Dwarf Galaxies Suggests Deviations from the Collisionless Cold Dark Matter Paradigm

The Astrophysical Journal Letters
Unraveling the nature of dark matter (DM) stands as a primary objective in modern physics. Here we present evidence suggesting deviations from the collisionless cold DM (CDM) paradigm.
Jorge Sánchez Almeida, Ignacio Trujillo, Angel R. Plastino   +2 more
doaj   +1 more source

Reduction of Oxide Inclusions During the High‐Frequency Welding of Steel via a Nonthermal Ar/H2 Plasma Jet

Advanced Engineering Materials, EarlyView.
High‐frequency (HF) welding of steel is limited by oxide inclusions that degrade weld quality. This study demonstrates, for the first time, the integration of a nonthermal Ar/H2 dielectric barrier discharge (DBD) plasma jet into HF welding. Local plasma treatment provides effective shielding and in‐situ oxide reduction, resulting in markedly fewer and ...
Viktor Udachin, Lienhard Wegewitz, René Gustus, Henning Wiche, Wolfgang Maus‐Friedrichs   +4 more
wiley   +1 more source

The detection of sub-solar mass dark matter halos

, 2009
Dark matter halos of sub-solar mass are the first bound objects to form in cold dark matter theories. In this article, I discuss the present understanding of "microhalos'', their role in structure formation, and the implications of their potential ...
, Bertschinger E, Bode P, Bringmann T, Bringmann T, Bryan G L, Colin P, Diemand J, Diemand J, Eke V R, Elahi P J Thacker R J Widrow L M Scannapieco E, Green A M, Heitmann K, Hofmann W (HESS Collaboration), Hooper D Stebbins A Zurek K M, Klypin A, Komatsu E, Kuhlen M Diemand J Madau P, March-Russell J D West S M, Martinez G D Bullock J S Kaplinghat M Strigari L E Trotta R, Martinez M (MAGIC Collaboration), Moore B, Ritz S, Savvas M Koushiappas, Springel V, Sreekumar P, Vogelsberger M, White S D M, Yoshida N, Zemp M, Zhao H S   +30 more
core   +1 more source

Population of Nonmetallic Inclusions in Liquid High‐Silicon Electrical Steel in Contact With MgO–C Refractories Based on Recyclates and Environmentally Friendly Binders

Advanced Engineering Materials, EarlyView.
The formation of nonmetallic inclusions (NMIs) was investigated in this study, carrying out immersion tests for 30 min at a temperature of 1600°C with liquid high‐silicon electrical steel (Si ≈ 3 mass‐%) and different MgO–C refractories. Conventional MgO–C refractories were considered, as well as MgO–C refractories containing MgO–C recyclate and ...
Lukas Neubert, Matheus Roberto Bellé, Florian Kerber, Dinesh Kumar Gunasekar, Hans‐Jörn Weddige, Christos G. Aneziris, Olena Volkova   +6 more
wiley   +1 more source

How Many Bursts Does It Take to Form a Core at the Center of a Galaxy?

The Astrophysical Journal
We present a novel method for systematically assessing the impact of the central potential fluctuations associated with bursty outflows on the structures of dark matter halos for classical and ultrafaint dwarf (UFD) galaxies.
Olivia Mostow, Paul Torrey, Jonah C. Rose, Alex M. Garcia, Niusha Ahvazi, Mariangela Lisanti, Nitya Kallivayalil   +6 more
doaj   +1 more source

Dark matter, sparticle spectroscopy and muon (g − 2) in SU(4) c × SU(2) L × SU(2) R

Journal of High Energy Physics, 2018
We explore the sparticle mass spectra including LSP dark matter within the framework of supersymmetric SU(4) c × SU(2) L × SU(2) R (422) models, taking into account the constraints from extensive LHC and cold dark matter searches.
M. E. Gómez, S. Lola, R. Ruiz de Austri, Q. Shafi   +3 more
doaj   +1 more source

Corrosion and Process Analysis of a Preoxidized MgO Recyclate‐Based Cermet Anode in Laboratory‐Scale Na‐Cryolite Molten Salt Electrolysis of Aluminum at 1000°C

Advanced Engineering Materials, EarlyView.
EDX elemental map of the pre‐oxidized MgO–steel cermet anode cross section after electrolysis. The development of inert anodes for aluminum electrolysis remains challenging due to the high corrosivity of cryolite‐based melts at 950°C–1000°C. This study investigates the corrosion and process behavior of a carbon‐free MgO–steel cermet anode derived from ...
Alexander Adamczyk, Farhan Hossain, Felipe A. Garcia Paz, Serhii Yaroshevskyi, Felix Drechsler, Daniel Vogt, Christos G. Aneziris, Alexandros Charitos   +7 more
wiley   +1 more source