Results 21 to 30 of about 58,910 (264)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

On the cold drawing of polymers

Computers & Mathematics with Applications, 1985
The paper treats the nonhomogeneous deformation of a slender bar of a viscoelastic material, a polymer. The authors considers the range of conditions under which a neck is formed in the bar, although it at first may both lengthen and deepen, and eventually growths in length without further change of depth.
openaire   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Effect of reduction ratio on die fill-out and hardness profile of cold-drawn polygonal rods made of acid resistant steel X6CrNiTi18-10 [PDF]

Journal of Mining and Metallurgy. Section B: Metallurgy
The study investigates the effect of the reduction ratio on strain hardening efficiency and load during the drawing process of austenitic acid-resistant steel X6CrNiTi18-10.
Rumiński M., Skubisz P., Micek P.
doaj   +1 more source

Multi-pass cold rolling and wire drawing process of gadolinium and its magnetocaloric effect

Journal of Materials Research and Technology, 2022
Owing to low ductility of magnetocaloric material (MCM)s, the plastic deformation process is quite challenging, and information available on the deformation process of MCMs is limited. In this study, the cold rolling and wire drawing processes of Gd wire
Jeong Hun Kim, Da Seul Shin, Jun Seok Yoon, Kwang Seok Lee   +3 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Practice of Cold Drawing Process Optimization of GCr15 Bearing Steel Rod

Teshugang, 2015
The effect of draft, cone angle and length of sizing belt of drawing die, and drawing speed on drawing stress and drawing surface accuracy of bearing steel GCr15 (1. 01% C, 1. 58% Cr) Φ11 mm rod coil has been analyzed. The optimization process for Φ11 mm
王莹莹, 杨鹏远
doaj  

NUMERICAL SIMULATION OF RESIDUAL STRESSES GENERATED IN THE WIRE DRAWING PROCESS FOR DIFFERENT PROCESS PARAMETERS [PDF]

Tecnologia em Metalurgia, Materiais e Mineração, 2014
The drawing process of steel bars is usually used to check better dimensional accuracy and mechanical properties to the material. In the other hand, the major concern found in manufacturing axes through this process is the appearance of distortion of ...
Juliana Zottis, Carla Adriana Theis Soares, Rafael Paini Pavlak, Tomaz Fantin de Souza, Vinicius Waechter Dias, Alexandre da Silva Rocha   +5 more
doaj   +1 more source