Results 31 to 40 of about 58,910 (264)

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian   +6 more
wiley   +1 more source

Effect of Drawing Pass on Softening or Plasticizing of Q235 Steel Bar during Electrochemical Cold Drawing

open access: yesMetals, 2020
In this work, the effect of drawing pass on the surface layer softening or plasticizing of Q235 steel bar during electrochemical cold drawing (ECD) was studied, as well as cold drawing in air (DIA) for comparison.
Jangli Guo, Tijun Chen, Bo Li
doaj   +1 more source

Extrusion‐Based Additive Manufacturing of Advanced Ceramics: Strengthening Mechanisms and Process Optimization Review

open access: yesAdvanced Engineering Materials, EarlyView.
This review comprehensively evaluates extrusion‐based additive manufacturing for advanced ceramics, detailing feedstock options and key process parameters. By critically addressing defect mechanisms like porosity and cracking, the work highlights optimization strategies through machine learning and advanced postprocessing.
Meisam Bakhtiari   +4 more
wiley   +1 more source

An Analysis on Wire Fracture in Cold-Drawing of Ferrite Stainless Steel 0Cr13C and Process Improvement

open access: yesTeshugang, 2017
The process for cold-drawn wire of steel 0Cr13C (/% : 0.02C, 0.32Si, 0.18Mn, 0.016P, 0.002S, 12.25Cr, 0.0140N) is φ5.5 mm hot-rolled rod annealed at 680~700°C -cold-drawing to φ2.0 mm coil-hydrogen annealing (HA) -cold-drawing to φ0.70 mm wire-HA-cold ...
宋云霞   +4 more
doaj  

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

open access: yesAdvanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett   +19 more
wiley   +1 more source

Influence of Cold Reduction on Structure and Properties of DQ Level Deep-Drawing Strip Steel

open access: yesTeshugang, 2010
Effect of 60% - 80% cold reduction on structure, texture and mechanical properties of 1. 4 ~0. 7 mm cold rolled deep-drawing strip steel from 3. 5 mm CSP (Compact Strip Production) hot rolled plate has been studied. Results show that with increasing cold
程晓杰   +6 more
doaj  

Versatile Pneumatic Twisted Coiled Actuators Enabled by Fiber‐Polymer Composite Fabrication

open access: yesAdvanced Functional Materials, EarlyView.
This work reports composite Pneumatic Twisted Coiled Actuators with embedded Kevlar fibers that convert pneumatic or hydraulic pressure into powerful linear motion. A novel precise manufacturing technique is used to systematically explore how design variables influence actuator mechanics and dynamics.
William J. Townsend   +5 more
wiley   +1 more source

Effect of Banded Structure in Low Carbon High Sulphur Free Cutting Steel on Crack Formation of Cold Drawn Products

open access: yesTeshugang, 2007
The longitudinal crack with 0.3 mm depth occurred in φ11.5 mm cold drawn products of low carbon high sulphur free cutting structural steel (0.07C,0.86Mn,0.06P,0.32S) to product some batches of rejection.
徐芗明
doaj  

Effect of solution treatment on grain boundary structure of Inconel 617 alloy bar

open access: yesCailiao gongcheng
The grain-boundary microstructure of Inconel 617 alloy hot-rolled rods during cold drawing and subsequent solution treatment is investigated using the electron backscattering diffraction (EBSD) technique. The results reveal that the microstructure of the
LU Jun   +3 more
doaj   +1 more source

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