Results 31 to 40 of about 63,948 (294)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

The Effect of Drawing Deformation Rate Induced Inhomogeneous Local Distortion on Phase Transformation of 304H Stainless Wire

open access: yesMetals, 2020
The micro/macro magnetic properties, local element distribution, martensite transformation, and mechanical properties of 304H stainless wires are determined for two cold drawing chains.
Qinhua Xu   +9 more
doaj   +1 more source

On the cold drawing of polymers

open access: yesComputers & Mathematics with Applications, 1985
The paper treats the nonhomogeneous deformation of a slender bar of a viscoelastic material, a polymer. The authors considers the range of conditions under which a neck is formed in the bar, although it at first may both lengthen and deepen, and eventually growths in length without further change of depth.
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Effect of reduction ratio on die fill-out and hardness profile of cold-drawn polygonal rods made of acid resistant steel X6CrNiTi18-10 [PDF]

open access: yesJournal of Mining and Metallurgy. Section B: Metallurgy
The study investigates the effect of the reduction ratio on strain hardening efficiency and load during the drawing process of austenitic acid-resistant steel X6CrNiTi18-10.
Rumiński M., Skubisz P., Micek P.
doaj   +1 more source

Multi-pass cold rolling and wire drawing process of gadolinium and its magnetocaloric effect

open access: yesJournal of Materials Research and Technology, 2022
Owing to low ductility of magnetocaloric material (MCM)s, the plastic deformation process is quite challenging, and information available on the deformation process of MCMs is limited. In this study, the cold rolling and wire drawing processes of Gd wire
Jeong Hun Kim   +3 more
doaj   +1 more source

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati   +10 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

Clinical Practice Guideline for Evaluation and Management of Peripheral Nervous System Manifestations in Sjögren's Disease

open access: yesArthritis Care &Research, EarlyView.
Objective Sjögren's disease is an autoimmune disorder that can impact multiple organ systems, including the peripheral nervous system (PNS). PNS manifestations, which can exist concurrently, include mononeuropathies, polyneuropathies, and autonomic nervous system neuropathies.
Anahita Deboo   +88 more
wiley   +1 more source

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