Results 41 to 50 of about 1,064,383 (300)
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Filaments and sheets of the warm-hot intergalactic medium
, 2012 Filaments, forming in the context of cosmological structure formation, are not only supposed to host the majority of the baryons at low redshifts in the form of the WHIM, but also to supply forming galaxies at higher redshifts with a substantial amount ...
Klar, J. S., Mücket, J. P.
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A Review on Galling of Aluminum in Cold Forming Processes
Düzce Üniversitesi Bilim ve Teknoloji DergisiAs world’s sustainability become the most influential topic, aluminum and its alloys are becoming the preferred material of the automotive industry because they allow vehicle weight to be reduced without compromising safety.
Hatice Sandallı, Mert Özdoğan
doaj +1 more source
Experimental Research on the Cold-Forming Effect of Cold-Formed Thick-Walled Steel
Buildings, 2023 To study the cold-forming effect on the yield strength distribution of cold-formed thick-walled steel, material tensile tests and axial compression tests were conducted on steel-lipped channels. To undertake the material tensile tests, five types of cold-formed lipped channel sections with varied thicknesses and nominal yield strengths were selected ...
Xiaochao Fu +3 more
openaire +2 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
MATEC Web of Conferences, 2018 In order to reduce friction and wear in cold forging of aluminium and its alloys a tremendous amount of lubricants is used. The main task of the liquid lubricants is the separation of tool and workpiece surfaces to avoid adhesion and abrasion.
Teller Marco +7 more
doaj +1 more source
Astrochemistry: overview and challenges [PDF]
, 2017 This paper provides a brief overview of the journey of molecules through the Cosmos, from local diffuse interstellar clouds and PDRs to distant galaxies, and from cold dark clouds to hot star-forming cores, protoplanetary disks, planetesimals and ...
van Dishoeck, Ewine F.
core +3 more sources
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Düzce Üniversitesi Bilim ve Teknoloji Dergisi, 2018 Civataüretiminin kritik prosesi olan ısıl işlem prosesi; soğuk şekillendirilenmalzemenin metalografik ve mekanik özelliklere olan etkisinin araştırılması,hem proses verimi hemde ürün performans kriterleri açısındandeğerlendirildiğinde sektörde deneysel ...
ALPER Baygut +2 more
doaj +1 more source