Results 51 to 60 of about 260,144 (267)

THERMAL EFFECT ANALYSIS OF ROLLING FRICTION IN HIGH SPEED COLD ROLL-BEATING FORMING

Jixie qiangdu, 2018
High-speed cold forming is a complex forming process coupling under multi factors, which has the rolling friction affecting the fluidity of the workpiece metal, and then affecting the quality and performance of the forming parts.
LI YuXi, LI Yan, CUI LiMu, XIAO JiMing, CUI FengKui   +4 more
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Reducing Maximum Punching Force in Sheet Cold Forming: A Numerical Study of a New Punch Design (Part I)

Metals
The present research investigates the optimization of the punching process in cold forming manufacturing, focusing on enhancing tool life, reducing damage, and improving product quality.
Abdelwaheb Zeidi, Mabrouka Akrout, Khaled Elleuch, António Pereira   +3 more
doaj   +1 more source

Influence of surface integrity on the plastic flow in analogous testing of 42CrMo4

MATEC Web of Conferences, 2018
Surface modification of workpieces for cold forming processes is common in industrial practice. Specific surface topographies manufactured by means of shot peening form lubricant pockets, which provide a continuous lubricating film throughout the process.
Hild Rafael, Feuerhack Andreas, Trauth Daniel, Hoffmann Dennis C., Kruppe Nathan C., Brögelmann Tobias, Bobzin Kirsten, Klocke Fritz   +7 more
doaj   +1 more source

Effect of cold rolling deformation before intermediate annealing on microstructure and properties of 6A16 aluminum alloy

Cailiao gongcheng, 2020
Effect of different cold rolling deformations before intermediate annealing on the microstructure and forming properties of 6A16 aluminum alloy sheet during subsequent processing was investigated by means of EBSD and mechanical properties tests.The ...
YAN Li-zhen, ZHANG Yong-an, XIONG Bai-qing, LI Xi-wu, LI Zhi-hui, CHEN Kai-xin   +5 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Reducing Abrasive Particle Generation in Dry Rotary Swaging by Utilizing DLC Hard Coated Dies

MATEC Web of Conferences, 2018
The emphasis of this paper is the investigation of the impact of the diamond like carbon (DLC) hard coating system on the amount of abrasive particles being generated during dry rotary swaging.
Böhmermann Florian, Herrmann Marius, Riemer Oltmann, Kuhfuss Bernd   +3 more
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Effect of Natural Aging on Cold Forming Performance of 2219 Aluminum Alloy. [PDF]

Materials (Basel), 2023
Li ZX, Shi YL, Xu LP, Jin JX.
europepmc   +1 more source