Results 61 to 70 of about 1,064,383 (300)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
A thermoviscoplastic model with damage for simultaneous hot/cold forging analysis [PDF]
, 2013 A constitutive model is presented for simultaneous hot/cold forming processes of steels. The phenomenological material theory is based on an enhanced rheological model and accounts temperature dependently for nonlinear hardening, thermally activated ...
Bröcker, C., Matzenmiller, A.
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
, 2012 Using observations from the GASS and COLD GASS surveys and complementary data from SDSS and GALEX, we investigate the nature of variations in gas depletion time observed across the local massive galaxy population.
Aalto +100 more
core +1 more source
Cold stress in captive great apes recorded in incremental lines of dental cementum [PDF]
, 2002 Incremental lines in dental cementum of museum specimens of 11 free-ranging great apes were compared to the respective structures in 5 captive specimens of known age-at-death, and with many known life-history parameters.
Cipriano, Alessandra
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
An infrared-submillimeter study of star-forming regions selected by the ISOSS 170um survey
, 2008 Using the ISOPHOT Serendipity Survey (ISOSS) at 170um a sample of galactic star-forming regions exhibiting very cold dust temperatures (< 20 K) and high masses (> 100 M_sun) has been established.
Beuther +43 more
core +1 more source
FE analysis of multi-cycle micro-forming through using closed-die upsetting models and forward extrusion models [PDF]
, 2007 Research in micro-forming leads to the investigation of the effects of heat generation in the workpiece and temperature changes in the tools during the forming.
Pan, W., Qin, Y.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Chemical Engineering Transactions, 2015 As a near net-shape advanced manufacturing technology, cold roll-beating is a dieless unconstrained incremental forming technology. For the features of the forming process, it is necessary to study the forming mechanism under thermal–mechanical coupling ...
Y.X. Li +5 more
doaj +1 more source