Results 41 to 50 of about 1,125,979 (313)

Peripheral kappa opioid receptor activation drives cold hypersensitivity in mice

bioRxiv, 2020
Noxious cold sensation is commonly associated with peripheral neuropathies, however, there has been limited progress in understanding the mechanism of cold pain.
Manish K. Madasu, L. Thang, Priyanka Chilukuri, Sree Palanisamy, Joel S. Arackal, T. Sheahan, Audra M. Foshage, R. Houghten, J. McLaughlin, J. McCall, R. Al-Hasani   +10 more
semanticscholar   +1 more source

Oxaliplatin administration increases expression of the voltage-dependent calcium channel α2δ-1 subunit in the rat spinal cord

Journal of Pharmacological Sciences, 2016
Oxaliplatin is a chemotherapeutic agent that is effective against various types of cancer including colorectal cancer. Acute cold hyperalgesia is a serious side effect of oxaliplatin treatment.
Ken Yamamoto, Mayuko Tsuboi, Toshie Kambe, Kenji Abe, Yoshihiko Nakatani, Kazuyoshi Kawakami, Iku Utsunomiya, Kyoji Taguchi   +7 more
doaj   +1 more source

Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling

Molecular Brain, 2020
Postoperative shivering and cold hypersensitivity are major side effects of acute and chronic opioid treatments respectively. TRPM8 is a cold and menthol-sensitive channel found in a subset of dorsal root ganglion (DRG) nociceptors.
Mircea Iftinca, Lilian Basso, Robyn Flynn, Charlie Kwok, Corinne Roland, Ahmed Hassan, Manon Defaye, Rithwik Ramachandran, Tuan Trang, Christophe Altier   +9 more
doaj   +1 more source

Cold Hypersensitivity in the Hands and Feet May Be Associated with Functional Dyspepsia: Results of a Multicenter Survey Study. [PDF]

Evid Based Complement Alternat Med, 2016
Aim. To investigate whether dyspepsia symptoms differ depending on the presence or absence of cold hypersensitivity in the hands and feet (CHHF). Methods.
Bae KH, Lee JA, Park KH, Yoo JH, Lee Y, Lee S.   +5 more
europepmc   +2 more sources

Accessibility of promoter DNA is not the primary determinant of chromatin-mediated gene regulation [PDF]

, 2019
DNA accessibility is thought to be of major importance in regulating gene expression. We test this hypothesis using a restriction enzyme as a probe of chromatin structure and as a proxy for transcription factors.
Chereji, Razvan V., Clark, David, Eriksson, Peter R., Ocampo, Josefina, Prajapati, Hemant Kumar   +4 more
core   +1 more source

Sphingosine 1-phosphate modulates antigen capture by murine langerhans cells via the S1P2 receptor subtype [PDF]

, 2012
Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and present it to T lymphocytes in the lymphoid organs.
A Kihara, A Kissenpfennig, A Kumar, A Martino, A Olivera, A Weigert, AD Christensen, Burkhard Kleuser, C Ocana-Morgner, C Ruedl, CC Norbury, CL Bennett, CL Bennett, DH Kaplan, DH Kaplan, E Guaguere, ES Trombetta, EY Seo, F Sparber, G Gollmann, G Schuhmachers, H Hackstein, H Liu, Heinfried H. Radeke, HH Radeke, I Reines, J Chun, Jagadeesh Bayry, JH Hong, K Kabashima, K Sarkar, K Takabe, Katrin Schaper, L Japtok, L Rose, L Ruwisch, LS Bursch, Lukasz Japtok, M Hara-Chikuma, M Matloubian, M Schröder, M Schuppel, MB Lutz, MC Kerr, ML Allende, ML Allende, N Romani, P Mitra, P Monti, R van de Ven, RH Kim, RM Steinman, S Spiegel, S Sullivan, S Xu, Se Kyoo Jeong, SH Wood, SP Zahner, T Hla, T Kitajima, T Walzer, V Brinkmann, W Baumer, W Baumer, W Baumer, Wolfgang Bäumer, Y Maeda, Y Yanagawa, YY Lan   +68 more
core   +5 more sources

Comparison of Vantej and Dente 91 Toothpastes in the Management of Dentin Hypersensitivity: A Randomised Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Dentinal hypersensitivity is a prevalent and distressing dental condition characterised by acute, transient pain or discomfort arising from exposed dentin in response to external stimuli, such as variations in temperature, mechanical ...
Ramesh Nagarajappa, Priyanca Panigrahi, Dharmashree Satyarup, Jagruti Nanda, Radha Prasanna Dalai, Sourav Chandra Bidysagar Bal, Sashikant Sethi   +6 more
doaj   +1 more source

Arabidopsis RecQl4A suppresses homologous recombination and modulates DNA damage responses [PDF]

, 2005
The DNA damage response and DNA recombination are two interrelated mechanisms involved in maintaining the integrity of the genome, but in plants they are poorly understood.
Bachrati, Bagherieh-Najjar, Bai, Blackburn, Bundock, Cohen, Courcelle, Cromie, De Silva, Dellaporta, Ellis, Fitzgerald, Frei, Gallego, Gallego, Gallego, Gherbi, Gray, Hanada, Hanin, Harrigan, Hartung, Henson, Imamura, Jackson, Jacques Hille, Johnson, Kitao, Krysan, Li, Lovett, Lowndes, McGlynn, McHugh, Mengiste, Michel, Mohammad B. Bagherieh-Najjar, Nakayama, Nakayama, Nugent, Onno M.H. Vries, Osborn, Pastink, Paul P. Dijkwel, Pierce, Puchta, Reiss, Riha, Riha, Rothstein, Sambrook, Seigneur, Sengupta, Sessions, Simon, Sinclair, Sladek, Sundaresan, Swoboda, Tercero, Ui, Valvekens, Watt, Wu, Yamagata   +64 more
core   +3 more sources

The roles of iPLA2, TRPM8 and TRPA1 in chemically induced cold hypersensitivity

Molecular Pain, 2010
Background The cooling agents menthol and icilin act as agonists at TRPM8 and TRPA1. In vitro, activation of TRPM8 by icilin and cold, but not menthol, is dependent on the activity of a sub-type of phospholipase A2, iPLA2. Lysophospholipids (e.g.
Andersson David A, Stoakley Natalie, Gentry Clive, Bevan Stuart   +3 more
doaj   +1 more source

Determination of the Activities Affected Due to Cold Intolerance after Peripheral Nerve Disorders

Bezmiâlem Science, 2023
Objective:Our study was designed to determine the activities affected due to cold intolerance (CI) after peripheral nerve disorders.Methods:Participants aged 18-65 who were diagnosed as having peripheral nerve disorder in the last year and whose ...
Özge Buket ARSLAN, Çiğdem ÖKSÜZ
doaj   +1 more source