Results 31 to 40 of about 159,298 (239)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

JWST imaging of the Pleiades: Anisotropy of turbulence in the cold neutral medium

Astronomy & Astrophysics
Interstellar medium studies rely on magnetohydrodynamic turbulence as a framework for interpretation. In this context, the statistical characterization of interstellar observations is of prime importance.
Vigoureux G., Flagey N., Boulanger F., Noriega-Crespo A., Guillet V., Alvarez-Castro A. J., de Jesus-Rivera N., Allys E., Delouis J. M., Falgarone E., Godard B., Guillard P., Levrier F., Lesaffre P., Marcowith A., Miville-Deschênes M. A., Pineau des Forêts G.   +16 more
doaj   +1 more source

THE THERMAL PRESSURE DISTRIBUTION OF A SIMULATED COLD NEUTRAL MEDIUM

The Astrophysical Journal, 2014
We numerically study the thermal pressure distribution in a gas with thermal properties similar to those of the cold neutral interstellar gas by analyzing three-dimensional hydrodynamic models in boxes with sides of 100 pc with turbulent compressible forcing at 50 pc and different Mach numbers. We find that at high pressures and for large Mach numbers,
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Neutral Gas Phase Distribution from H I Morphology: Phase Separation with Scattering Spectra and Variational Autoencoders

The Astrophysical Journal
Unraveling the multiphase structure of the diffuse interstellar medium as traced by neutral hydrogen (H i ) is essential to understanding the lifecycle of the Milky Way. However, H i phase separation is a challenging and underconstrained problem.
Minjie Lei, S. E. Clark, Rudy Morel, E. Allys, Iryna S. Butsky, Caleb Redshaw, Drummond B. Fielding   +6 more
doaj   +1 more source

The effects of bathing in neutral bicarbonate ion water

Scientific Reports, 2021
Percutaneously absorbed carbon dioxide enhances blood flow. The mechanism by which it does so is unclear, but we hypothesized that it involves bicarbonate ions.
Tomoe Yamazaki, Ryoko Ushikoshi-Nakayama, Supriya Shakya, Daisuke Omagari, Naoyuki Matsumoto, Chiyoko Nukuzuma, Tomoko Komatsu, Masaichi Chang-il Lee, Hiroko Inoue, Ichiro Saito   +9 more
doaj   +1 more source

High energy level diet improves the growth performance and rumen fermentation of yaks in cold weather

Frontiers in Veterinary Science, 2023
To date, no research has been done on energy requirements for yaks in Tibetan cold weather. The findings of the current study provide proper energy requirements for yaks would facilitate scientific feeding of fattening yaks in cold weather.
Yanbin Zhu, Yanbin Zhu, Guangming Sun, Luosang-dunzhu, Xin Li, Luosang-zhaxi, Suolang-zhaxi, Suolang, Ciyang, Cidan-yangji, Basang-wangdui, Feng Pan, Quanhui Peng   +12 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A New Constraint on the Relative Disorder of Magnetic Fields between Neutral Interstellar Medium Phases

The Astrophysical Journal
Utilizing Planck polarized dust emission maps at 353 GHz and large-area maps of the neutral hydrogen (H i ) cold neutral medium (CNM) fraction ( f _CNM ), we investigate the relationship between dust polarization fraction ( p _353 ) and f _CNM in the ...
Minjie Lei, S. E. Clark
doaj   +1 more source

Distribution and Kinematics of H i through Raman He ii Spectroscopy of NGC 6302

The Astrophysical Journal, 2023
The young planetary nebula NGC 6302 is known to exhibit Raman-scattered He ii features at 6545 Å and 4851 Å. These features are formed through inelastic scattering of He ii λλ 1025 and 972 with hydrogen atoms in the ground state, for which the cross ...
Seok-Jun Chang, Hee-Won Lee, Jiyu Kim, Yeon-Ho Choi   +3 more
doaj   +1 more source