Results 181 to 190 of about 8,030,856 (244)

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

open access: yesAdvanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng   +7 more
wiley   +1 more source

Roles of Cold Plasma Treatment on the Functional Properties of Plant-Based Proteins. [PDF]

open access: yesInt J Food Sci
Adejoh AO   +5 more
europepmc   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

open access: yesAdvanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin   +13 more
wiley   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

open access: yesAdvanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir   +3 more
wiley   +1 more source

Circulating succinate changes during acute cold exposure are not related with brown adipose tissue in humans. [PDF]

open access: yesJ Physiol Biochem
Osuna-Prieto FJ   +7 more
europepmc   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

open access: yesAdvanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee   +5 more
wiley   +1 more source

Influence of cold plasma activation on fluoride uptake and demineralization of enamel. [PDF]

open access: yesClin Oral Investig
Schmidt A   +7 more
europepmc   +1 more source

Cr1/4NbSe2‐Single Crystal Growth and Evolution of Antiferromagnetic Correlated States

open access: yesAdvanced Science, EarlyView.
High‐quality single crystals Cr1/4NbSe2 were synthesized and comprehensively characterized for the first time. Advanced structural, electronic, and magnetic measurements uncover a correlated antiferromagnetic state, resolving longstanding inconsistencies regarding magnetic behavior derived from earlier polycrystal studies.
Nour Abdelrahman   +16 more
wiley   +1 more source

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