Results 31 to 40 of about 3,040,952 (304)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Synthesis of atomically dispersed catalysts via hydrogen embrittlement-like assisted thermal activation for acidic oxygen reduction

Nature Communications
Atomically dispersed catalysts based on 3d metals have been extensively explored in the catalytic field, but stabilizing 4d and 5d metals like Ru, Pd, and Pt as single atoms remains a challenge due to their high cohesive energies.
Pan Guo, Yunkun Dai, Yunlong Zhang, Bing Liu, Miao Ma, Bo Liu, Ziyu Zhang, Zigang Zhao, Aibing Chen, Lixiao Shen, Lei Zhao, Zhenbo Wang   +11 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Cold Storage of Strawberry Plants

International Journal of Fruit Science, 2005
Abstract Cold storage has not only been a good method to overwinter strawberry plants safely and to compensate for the lack of natural chilling. Initially cold stored plants were used for early spring cropping only. Meanwhile this technique has become a normal commercial practice among growers in central Europe and has given them the opportunity to ...
Lieten, P., Evenhuis, A., Baruzzi, G.
openaire   +1 more source

Research on Dynamic Energy Consumption of Front Warehouse Assembly Cold Storage and Analysis of Influencing Factors

Zhileng xuebao, 2021
To study the dynamic load of assembly cold storage under actual operating conditions, this study used prefabricated cold storage in Shanghai as the research object and tested its actual load with a refrigerated area.
Gu Han, Zhang Hua, Chen Xi, Zhao Ju
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Optimal duration of cold storage for enhancing the proliferative biological control efficacy of Aphidoletes aphidimyza (Rondani)

Biological Control
Cold storage of Aphidoletes aphidimyza pupae improves pest management. However, its effects on the larvae remain unclear. Thus, this study examined the impact of cold treatment at 5 °C for 5, 10, and 15 days on A. aphidimyza larvae.
Jinmin Yuan, Xiaofei Yu, Hanjie Guan, Zhining Miao, Ting Liu, Maofa Yang, Feng Zhang, Chunyang Huang   +7 more
doaj   +1 more source

Metabolite Profiling Reveals the Effect of Cold Storage on Primary Metabolism in Nectarine Varieties with Contrasting Mealiness

Plants, 2023
Chilling injury is a physiological disorder caused by cold storage in peaches and nectarines. The main symptom of chilling injury is mealiness/wooliness, described as a lack of juice in fruit flesh. In this work, we studied two nectarine varieties (Andes
Patricio Olmedo, Baltasar Zepeda, Joaquín Delgado-Rioseco, Carol Leiva, Adrián A. Moreno, Karen Sagredo, Francisca Blanco-Herrera, Romina Pedreschi, Rodrigo Infante, Claudio Meneses, Reinaldo Campos-Vargas   +10 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source