Results 101 to 110 of about 182,891 (332)

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

Breaking the long dormancy of seeds of the Cornus mas L. species

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2007
The present study was focused on breaking the long dormancy of harvested and treated seed of the Cornelian cherry. We used stratification, which accelerates ripening, enables rapid termination of dormancy and removes all obstacles to germination.
Vojtěch Řezníček
doaj   +1 more source

Stratified precessional flow in spherical geometry [PDF]

, 2013
We investigate numerically in spherical geometry the interaction of stratification with precession. Both stable stratification and unstable stratification are studied. In the parameter regime we are concerned with, stable stratification suppresses the precessional instability, whereas unstable stratification and precession can either stablise or ...
arxiv   +1 more source

Constraining the effect of convective inhibition on the thermal evolution of Uranus and Neptune [PDF]

arXiv, 2021
The internal heat flows of both Uranus and Neptune remain major outstanding problems in planetary science. Uranus' surprisingly cold effective temperature is inconsistent with adiabatic thermal evolution models, while Neptune's substantial internal heat flow is twice its received insolation.
arxiv  

Seed germination of valuable high-altitude medicinal plants of southern Africa [PDF]

, 2005
Germination of nine important medicinal plant species from the high altitudes of southern Africa was investigated in relation to different environmental parameters.
Berjak, P., Kulkarni, M.G., Sparg, S.G., van Staden, J.   +3 more
core   +1 more source

Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer

Advanced Science, EarlyView.
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin, Yongbiao Huang, Bin Li, Yuan Wang, Yan Li, Zhirui Chen, Zhe Tang, Chaofan Liu, Lei Zhang, Xianglin Yuan, Jianbo Tian, Bo Liu   +11 more
wiley   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5

Advanced Science, EarlyView.
Li et al. innovatively map the kinase‐substrate network in esophageal cancer metastasis. Their study demonstrates that LIM domain kinase 1 (LIMK1) and Cyclin‐dependent kinase 5 (CDK5) synergistically increase the phosphorylation of β‐catenin, thereby activating the Wnt/β‐catenin signaling pathway to promote esophageal cancer metastasis.
Shu‐Jun Li, Zhuo‐Ran Liang, Zhi‐Chao Liu, Xue‐Ping Luo, Jun‐Yi Li, Xiao‐Mei Yu, Xuan‐Zhang Huang, Yan He, Tao‐Yang Xu, Jiao‐Jiao Xu, Shao‐Cong Peng, Yu‐Xiang Song, Yan He, Xiao‐Wan Zhuang, Can‐Can Zheng, Fan Zhang, Alfred King‐Yin Lam, Wei Dai, Ming‐Liang He, Bo Liu, Qi Zhao, Guo‐Liang Lu, Jin‐Bao Liu, Zhen‐Ning Wang, Zhi‐Gang Li, Ze‐Xian Liu, Wen‐Wen Xu, Bin Li   +27 more
wiley   +1 more source

Methodological and Physiological Study during Seed Dormancy Release of Symplocos paniculata

Plants
Symplocos paniculata are reported to exhibit seed dormancy, which impedes its cultivation and widespread adoption. In this study, a comprehensive method was established to overcome seed dormancy by subjecting seeds to scarification in 98% H2SO4 for 10 ...
Luhong Zhang, Qiaoyu Tang, Peiwang Li, Changzhu Li, Lijuan Jiang, Jingzhen Chen, Yunzhu Chen, Qiang Liu, Yan Yang   +8 more
doaj   +1 more source

Seed germination of Paederotella pontica (Rupr. ex Boiss.) Kem-Nath.- rare endemic species of the Caucasus

BIO Web of Conferences, 2020
Paederotella pontica is a Colchis tertiary relict species, regional narrow endemic to the Caucasus, representative of an oligotypic genus. The aim of this study was to determine dormancy-breaking requirements and develop seed germination protocol for P ...
Shakarishvili Nana
doaj   +1 more source