Results 61 to 70 of about 5,544,180 (301)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2022 The CO2 sorption behavior of commercially available zeolites such as 3A, 4A, 5A, and 13X is considered at low temperatures for CO2 removal from ambient air or direct air capture (DAC).
Cornelia Rosu (1262976) +6 more
core +1 more source
The effects of age and sex on the body cooling rates. [PDF]
, 1975 PhDWhen the head was cooled for 30 minutes, sublingual temperature fell by as much as 4.45°C below oesophageal which remained steady. Insulation of the head prevented this local cooling.
Sloan, R.E.G.
core +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Jurnal Teknologi & Industri Hasil Pertanian, 2022 Ketupat is an Indonesian indigenous food made from rice which is wrapped by young coconut leaves and cooked into the boiling water. Storage temperatures might affect the physicochemical and microbiological characteristics of ketupat.
Isnaini Rahmadi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Frontiers in Physiology, 2019 Transient receptor potential melastatin 8 (TRPM8) is a major receptor of cold environment. Recently, we found that cigarette smoke extract (CSE) upregulated TRPM8 mRNA and protein expression in bronchial tissues that made them more sensitive to cold ...
Jing Wang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Potential Impacts of Meteorological Variables on Acute Ischemic Stroke Onset
Risk Management and Healthcare Policy, 2020 Xuemei Qi,1 Zhongyan Wang,2 Xiaoshuang Xia,1 Juanjuan Xue,1 Yumeng Gu,1 Suqin Han,3 Lin Wang,2 Xin Li,1,* Sean X Leng4,* 1Department of Neurology, The Second Hospital of Tianjin Medical University, Tianjin, People’s Republic of China; 2Department ...
Qi X +8 more
doaj