Results 131 to 140 of about 57,221 (225)

Small Molecule Adjuvants Potentiate Colistin Activity and Attenuate Resistance Development in Escherichia coli by Affecting pmrAB System

Infection and Drug Resistance, 2020
Dipak Kathayat,1 Linto Antony,2 Loic Deblais,1 Yosra A Helmy,1 Joy Scaria,2 Gireesh Rajashekara1 1Food Animal Health Research Program, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH 44691, USA; 2Animal Disease ...
Kathayat D, Antony L, Deblais L, Helmy YA, Scaria J, Rajashekara G   +5 more
doaj  

Bavachin Rejuvenates Sensitivity of Colistin against Colistin-Resistant Gram-Negative Bacteria

International Journal of Molecular Sciences
The emergence of plasmid-mediated colistin resistance threatens the efficacy of colistin as a last-resort antibiotic used to treat infection caused by Gram-negative bacteria (GNB). Given the shortage of new antibiotics, the discovery of adjuvants to existing antibiotics is a promising strategy to combat infections caused by multidrug-resistant (MDR ...
Li, Jie, Han, Ning, He, Zhengyuan, Dai, Xiaolan, Zhao, Feifei, Li, Yangyang, Xiong, Wenguang, Zeng, Zhenling   +7 more
openaire   +2 more sources

Genetic and structural basis of colistin resistance in Klebsiella pneumoniae: Unravelling the molecular mechanisms

Journal of Global Antimicrobial Resistance
Objective: Antimicrobial resistance (AMR), together with multidrug resistance (MDR), mainly among Gram-negative bacteria, has been on the rise. Colistin (polymyxin E) remains one of the primary available last resorts to treat infections caused by MDR ...
Sahar Alousi, Jamal Saad, Balig Panossian, Rita Makhlouf, Charbel Al Khoury, Kelven Rahy, Sergio Thoumi, George F. Araj, Rony Khnayzer, Sima Tokajian   +9 more
doaj   +1 more source

Colistin Resistance among Multi-Drug Resistant Gram-Negative Bacteria in Iran: A Systematic Review and Meta-Analysis

Novelty in Biomedicine
Background: Colistin, a last-resort antibiotic, faces a growing threat from antibiotic resistance. This study aims to comprehensively assess colistin resistance in clinical isolates of Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii ...
Fahimeh Hadavand, Fatemeh Khelghati, Arash Seifi, Shirin Afhami, Negin Esmailpour, Mahbobeh Alizadeh, Pardis Moradnejad, Fatemeh Nasirpour Seilakhori, Mohammad Javad Nasiri   +8 more
doaj   +1 more source

Colistin resistance in ESBL- and Carbapenemase-producing Escherichia coli and Klebsiella pneumoniae clinical isolates in Cambodia

Journal of Global Antimicrobial Resistance
: Objectives: Despite the critical importance of colistin as a last-resort antibiotic, limited studies have investigated colistin resistance in human infections in Cambodia.
Mallorie Hide, Soda Meng, Sokleaph Cheng, Anne-Laure Bañuls, Santy KY, Chantana YAY, Denis Laurent, Gauthier Delvallez   +7 more
doaj   +1 more source

Evaluation of Co-production of Colistin Resistance and ESBL Genes among Gramnegative Clinical Isolates from Usmanu Danfodiyo University Teaching Hospital Sokoto, Nigeria

UMYU Journal of Microbiology Research
The emergence of antimicrobial resistance (AMR) is a major threat to global health. Its effects include high mortality and morbidity rates, treatment failure, and increased treatment costs.
Nuhu, T., Olawale, S. A., Raji, M. I. O.
doaj   +1 more source

Double-carbapenem regimen, alone or in combination with colistin, in the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae (CR-Kp) [PDF]

, 2017
Aloj, F., Castaldi, D., D'Abramo, A., De Angelis, M., Gizzi, F., Mascellino, M. T., Mastroianni, C. M., Oliva, Alessandra, Scorzolini, L., Storto, M., Vullo, V.   +10 more
core   +1 more source

Prevalence and molecular characterization of colistin resistance in Pseudomonas aeruginosa isolates: insights from a study in Ardabil hospitals

BMC Microbiology
Background Pseudomonas aeruginosa is a common cause of nosocomial infections. However, the emergence of multidrug-resistant strains has complicated the treatment of P. aeruginosa infections. While polymyxins have been the mainstay for treatment, there is
Saghar Jafari-Ramedani, Maryam Nazari, Mohsen Arzanlou, Hadi Peeri-Dogaheh, Amirhossein Sahebkar, Farzad Khademi   +5 more
doaj   +1 more source

A Scientific Roadmap for Antibiotic Discovery: A Sustained and Robust Pipeline of New Antibacterial Drugs and Therapies is Critical to Preserve Public Health [PDF]

, 2016
In recent decades, the discovery and development of new antibiotics have slowed dramatically as scientific barriers to drug discovery, regulatory challenges, and diminishing returns on investment have led major drug companies to scale back or abandon ...
Allan Coukell, Carolyn Shore, Elizabeth Jungman, Kathy Talkington, Pooja Kothari, Susan K. Urahn   +5 more
core  

Isolation of colistin-resistant Hafnia alvei [PDF]

Journal of Medical Microbiology, 2009
Savini V, Catavitello C, Talia M, Balbinot A, Febbo F, POMPILIO, ARIANNA, DI BONAVENTURA, GIOVANNI, PICCOLOMINI, Raffaele, D'Antonio D.   +8 more
openaire   +3 more sources