Results 101 to 110 of about 461,819 (327)

Evaluation of the Upper Gastrointestinal Tract in Ulcerative Colitis Patients [PDF]

, 2018
To analyze the clinical characteristics of patients with ulcerative colitis who have upper gastrointestinal lesions, we retrospectively reviewed the data of 216 patients with ulcerative colitis who underwent esophagogastroduodenoscopy at our institute in
Hiraoka, Sakiko, Inokuchi, Toshihiro, Iwamuro, Masaya, Kato, Ryo, Kondo, Yoshitaka, Okada, Hiroyuki, Takahara, Masahiro, Takashima, Shiho, Tanaka, Takehiro   +8 more
core   +1 more source

Intestinal Epithelial‐Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78‐mediated Endoplasmic Reticulum Stress

Advanced Science, EarlyView.
USP13 deficiency in intestinal epithelial cells aggravates DSS‐induced colitis by enhancing ER stress and apoptosis. USP13 interacts with GRP78 and reduces its K63‐linked ubiquitination to alleviate epithelial injury. Restoring USP13 expression or targeting the USP13‐GRP78 axis may represent a promising strategy for treating inflammatory bowel disease ...
Chenchen Qian, Chenghong Hu, Yong Xu, Wentao Xu, Zhe Wang, Wan Gan, Weiyang Tang, Lijiang Huang, Aleksandr V. Samorodov, Yi Wang   +9 more
wiley   +1 more source

Bacteroides Fragilis‐Derived Outer Membrane Vesicles Deliver MiR‐5119 and Alleviate Colitis by Targeting PD‐L1 to Inhibit GSDMD‐Mediated Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Bacteroides fragilis‐derived outer membrane vesicles deliver miR‐5119 and alleviate colitis by targeting PD‐L1 to inhibit GSDMD‐mediated neutrophil extracellular trap formation. Abstract Inflammatory bowel disease (IBD) results from a breakdown in the symbiotic relationship between the intestinal commensal microflora and the mucosal immune system.
Yi Yang, Lanmengxi Yang, Yilin Yang, Haiyi Deng, Shiyu Su, Yinxiao Xia, Jin Su, Yuheng Liu, Junwei Wu, Jing Zhang, Yao Liao, Lifu Wang   +11 more
wiley   +1 more source

Cerbral Venous Thrombosis in Ulcerative Colitis and Review of the Literature

Canadian Journal of Gastroenterology, 1991
A 30-year-old man with an eight year history of ulcerative colitis developed left occipital headache, mental confusion, dysphasia and right-sided weakness when his bowel disease was asymptomatic.
Hugh Chaun, Jeff H Beckman, Terence G Sparling   +2 more
doaj   +1 more source

Neutrophil Extracellular Traps Sustain Inflammatory Signals in Ulcerative Colitis.

Journal of Crohn's & Colitis, 2019
BACKGROUND AND AIMS In ulcerative colitis [UC], mucosal damage occurs in areas that are infiltrated with neutrophils. The antimicrobial function of neutrophils relies in part on the formation of extracellular web-like structures, named neutrophil ...
V. Dinallo, I. Marafini, D. Di Fusco, F. Laudisi, E. Franzè, A. Di Grazia, M. Figliuzzi, F. Caprioli, C. Stolfi, I. Monteleone, G. Monteleone   +10 more
semanticscholar   +1 more source

Anti‐Inflammatory Mechanisms of Selenium Nanosheets in Ulcerative Colitis: Protein Corona, GP130 Interaction, and Transcriptomic Profile

Advanced Science, EarlyView.
SeNSs provide a biocompatible, anti‐inflammatory UC therapy. SeNSs form protein coronas enriched with AKT/PI3K/NF‐κB pathway proteins, suppress GP130 via hydrophobic interactions, and inhibit pro‐inflammatory cytokines. In DSS‐induced UC mice, SeNSs reduce inflammation, tissue damage, and disease activity by modulating cytokine, chemokine, and ...
Dingyi Shen, Li Gong, Wei Yang, Jiaqi Luo, Zhen Jin, Youzhi Tang   +5 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Hyposplenism in gastro-intestinal disease [PDF]

, 1994
The hazards of living without a spleen were recognised by the paediatricians in the early 1960’s when they focussed attention on the syndrome of fulminant sepsis, often due to pneumococcal infection, occurring in young children within the first two years
Muller, Andre F., Toghill, P. J.
core   +1 more source

The Probiotic Parabacteroides johnsonii Ameliorates Metabolic Disorders Through Promoting BCAAs to BSCFAs Conversion

Advanced Science, EarlyView.
Clinical discovery and the proposed underlying mechanism by how P. johnsonii ameliorated metabolic disorders. Abstract The gut bacterium Parabacteroides spp. is increasingly recognized for its therapeutic potential in treating metabolic disorders. However, the role of Parabacteroides johnsonii in metabolic disorders is never reported.
Yimeng Chen, Shujun Jiang, Haolu Wang, Mengzhen Si, Haixia Wu, Xinyi Liang, Shenmeng Yao, Yanliang Zhang, Xiaodong Wen, Jie Yang   +9 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source