Results 101 to 110 of about 249,629 (285)

Integrating APCS Score With Dual Biomarker Testing (FIT + mSEPT9) for Precision Risk Stratification and Predictive Modeling in High‐Risk Populations for Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Asia‐Pacific Colorectal Screening (APCS) risk stratification was combined with quantitative fecal immunochemical test (FIT) and plasma methylated Septin9 to identify advanced colorectal neoplasia in a high‐risk cohort. The integrated model showed high apparent discrimination, while internal validation indicated a modest and uncertain incremental ...
WeiKang Ye, Wei Xu, WenTing Yu, Xiuping Wan, Liu He, Maoning Liu, XinMing Lei   +6 more
wiley   +1 more source

The Compartive Study of Prevalence of Ulcerative Colitis in General Population with MS Patients

مجله دانشکده پزشکی اصفهان, 2011
Background: Multiple sclerosis and ulcerative colitis are two chronic and disabling disease that cause many problems to patients. Until now there is not a good study to determine relation and similarity between this disease.
Masood Etemadifar, Ahmad Chitsaz, Maryam Mollabashi, Azam Moradi, Mehdi Teimouri, Shirin Ashkbosi   +5 more
doaj  

Local Recurrence and Oncological Outcomes After Transanal Total Mesorectal Excision With Intersphincteric Resection for Lower Rectal Cancer: A Nationwide Multicenter Cohort Study (Ta‐Ta‐Mi Study)

Annals of Gastroenterological Surgery, EarlyView.
The 3‐year local recurrence (LR), recurrence‐free survival, and overall survival rates were 7.3%, 79.5%, and 98.1%, respectively. Multivariable analysis identified circumferential resection margin (CRM)/radial margin (RM) positivity as an independent risk factor for LR.
Kan Tanabe, Shinichiro Mori, Kenji Baba, Takeru Matsuda, Ichiro Takemasa, Koji Okabayashi, Chikayoshi Tani, Tatsuya Manabe, Yoshihiro Kakeji, Takao Ohtsuka, Seiichiro Yamamoto, Takeshi Naitoh, Ta‐Ta‐Mi Study Group Collaborative of the Japan Society of Laparoscopic Colorectal Surgery   +12 more
wiley   +1 more source

ULCERATIVE COLITIS IN CHILDREN [PDF]

, 2009
Chronic nonspecific ulcerative colitis remaine a disease of unkown etiology, although much new information continues to be gleaned from basic research and clinical trials. In most instances, ulcerative colitis respond to medical therapy.
Florea Iordăchescu
core   +2 more sources

Translational Macrophage Mechano‐Immunotherapy for Next‐Generation Implantable Biomaterials

Advanced NanoBiomed Research, EarlyView.
This review explores how macrophage mechanosensing drives inflammation, fibrosis and foreign body responses to implanted biomaterials. It examines emerging pharmacological strategies to modulate mechanotransduction, alongside biomaterial platforms for localised drug delivery, clinical translation, regulatory considerations and standardised testing ...
Xueying Xu, Ian L. Chin, Richard P. Tan
wiley   +1 more source

Durable and Additive Disease Control at 52 Weeks With Ixekizumab Plus Tirzepatide Versus Ixekizumab Alone in Adults With Psoriatic Arthritis and Obesity or Overweight: Additional Results From a Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective Obesity or overweight occurs in 72% to 82% of individuals with psoriatic arthritis (PsA). Previous data revealed greater disease control with concomitant ixekizumab (IXE) and tirzepatide (TZP) versus IXE alone in adults with active PsA and obesity or overweight with at least one weight‐related comorbidity at the week 36 primary end point. The
Joseph F. Merola, Cynthia E. Kartman, Peter Fischer, Philip Mease, Alan Kivitz, Naveed Sattar, Laura C. Coates, Daniel Aletaha, Luna Sun, Yurong Chen, Ketan Marulkar, Natalia Bello, Anabela Cardoso, Mark C. Genovese, Alexis Ogdie   +14 more
wiley   +1 more source

Lifestyle Issues in Inflammatory Bowel Disease – Smoking

Canadian Journal of Gastroenterology, 1994
During the pa t decade, smoking habit has been identified as a major exogenous factor in inflammatory bowel disease (IBD). It is associated not only with the development of the disease but al o with the clinical course in established disease.
Cecilia Benoni
doaj   +1 more source

Sustained Inhibition of Structural Damage Progression and Improvements in Disease Activity With Guselkumab in Biologic‐Naïve Participants with Active and Erosive Psoriatic Arthritis: Results Through Week 48 of the Phase 3b Randomized, Double‐Blind, Placebo‐Controlled APEX Study

Arthritis &Rheumatology, Accepted Article.
Objective In APEX, guselkumab, which binds to the IL‐23p19 subunit and CD64 on IL‐23‐producing cells, demonstrated significant joint efficacy and inhibition of structural damage progression in participants with active and erosive PsA through Week (W)24; W48 findings are reported herein. Methods The APEX modified full analysis set included 1020 biologic‐
Christopher T. Ritchlin, Philip J. Mease, Laura C. Coates, Alexa P. Kollmeier, Bei Zhou, Yusang Jiang, Karen Bensley, Koeun Im, Rattandeep Batra, Karissa Lozenski, Soumya D. Chakravarty, Proton Rahman, Désirée van der Heijde   +12 more
wiley   +1 more source

Oral vancomycin solution is superior to capsule in inducing clinical biomarker and endoscopic remission in children with atypical ulcerative colitis

British Journal of Clinical Pharmacology, EarlyView.
Aims Atypical colitis (presenting reverse gradient colitis, backwash ileitis or rectal sparing) is associated with primary sclerosing cholangitis–ulcerative colitis (PSC). Oral vancomycin has been used to manage paediatric atypical colitis with/without confirmed PSC. Different preparations had shown different efficacy.
Laura Räisänen, Fariha Balouch, Claire Reilly, Christopher Burgess, Peter Lewindon   +4 more
wiley   +1 more source

Prevalence of pregnancy and birth outcomes following biologic exposure in immune‐mediated inflammatory diseases: A population‐based study

British Journal of Clinical Pharmacology, EarlyView.
Aims Almost 5% of pregnancies are affected by immune‐mediated inflammatory diseases (IMIDs). As treatments become available, understanding their use during pregnancy is important. We aimed to describe maternal, pregnancy and infant outcomes among IMID pregnancies exposed to biologic therapies. Methods Using the Merative™ MarketScan® Commercial Database,
Leah K. Flatman, Lisiane F. Leal, Gabra Nohmie, Anick Bérard   +3 more
wiley   +1 more source