Results 111 to 120 of about 471,997 (328)

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, EarlyView.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity

Health and Quality of Life Outcomes, 2008
Background Ulcerative colitis disease activity is determined by measuring symptoms and signs. Our aim was to determine which symptom domains are frequent and responsive to change in the evaluation of disease activity, which are those defined by three ...
Wang Sijian, Zimmermann Ellen M, Dave Maneesh, Wren Patricia A, Khan Tahira, Waljee Akbar K, Joyce Joel C, Zhu Ji, Higgins Peter DR   +8 more
doaj   +1 more source

Restorative proctocolectomy with ileal pouch reservoir in ulcerative colitis : the first series from Malta [PDF]

, 1991
Seventy five to eighty percent of patients with ulcerative colitis are more or less satisfactorily treated medically. Surgery cures the disease, but because proper surgical therapy has until recently necessitated a permanent ileostomy, physicians and ...
Gatt, Dennis
core  

Environmental Factors in the Relapse and Recurrence of Inflammatory Bowel Disease:A Review of the Literature [PDF]

, 2015
The causes of relapse in patients with Crohn's disease (CD) and ulcerative colitis (UC) are largely unknown. This paper reviews the epidemiological and clinical data on how medications (non-steroidal anti-inflammatory drugs, estrogens and antibiotics ...
A Bitton, A Bitton, A Dignass, A Kaser, A Lunderquist, A Timmer, AJ Wakefield, AM Meyer, AN Ananthakrishnan, Andrew R. Hart, AP Dhillon, B Boye, BD Levy, C Abraham, C Luong, C Mowat, CN Bernstein, CS Guerreiro, CS North, D Lader, DA Gorard, DC Baumgart, DC Baumgart, E Lindberg, E Stepien, EA Magee, EA Magee, EA Miles, EF Foley, EM Sternberg, F Backhed, F Casellas, FN Aberra, G Bonizzi, G Bouma, G Cipolla, G Savoye, GE Reese, GF Bonner, GP Chrousos, H Brunner, H Tornqvist, IC Solberg, J Cosnes, J Cosnes, J Cosnes, J Eaden, JA Dominitz, JA Mancini, JB Felder, JC Meijers, JM Evans, KJ Khan, KS Rothfuss, L Beaugerie, L Beaugerie, L LeResche, L Lu, LM Lichtenberger, LR Sutherland, LR Sutherland, M Aslam, M Cottone, M Dybdahl, MB Grisham, MC Aldhous, MC Pitcher, MN Merrett, MT Severinsen, NJ Simmonds, NP Thompson, O Hovde, OA Hatoum, P Seksik, PJ Loll, R Reid, R Schreck, RD Cohen, RK Linskens, RM Beattie, RS Barua, S Danese, S Hayashi, S Levenstein, S Parcell, S Sigaud, S Singh, S Zhang, Simon S. M. Chan, SL Jowett, SM Collins, SM Collins, SS Hecht, ST Smale, SU Christl, SV Kane, T Hisamatsu, THJ Florin, Thomas D. Martin, U Erikson   +99 more
core   +1 more source

DR5 Governs Compound Exocytosis in Colonic Goblet Cells via TATA‐Box Binding Protein‐Dependent Bestrophin‐2 Transcriptional Regulation

Advanced Science, EarlyView.
DR5 knockout exhibits a thinner colonic mucus layer, leading to mild dysbiosis, increased susceptibility to Citrobacter rodentium invasion, and exacerbated epithelial injury. Mechanistically, DR5 binds transcription factor TBP, which regulates the expression of gene Best2 via its promoter.
Ying Wang, Xinyun Li, Yong Wang, Chuhe Yang, Xiaopei Gao, Ke Zhu, Yihang Ren, Jingxin Li, Chuanyong Liu, Bing Xue   +9 more
wiley   +1 more source

The Compartive Study of Prevalence of Ulcerative Colitis in General Population with MS Patients

مجله دانشکده پزشکی اصفهان, 2011
Background: Multiple sclerosis and ulcerative colitis are two chronic and disabling disease that cause many problems to patients. Until now there is not a good study to determine relation and similarity between this disease.
Masood Etemadifar, Ahmad Chitsaz, Maryam Mollabashi, Azam Moradi, Mehdi Teimouri, Shirin Ashkbosi   +5 more
doaj  

Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response

Nature Communications, 2019
Molecular mechanisms driving disease course and response to therapy in ulcerative colitis (UC) are not well understood. Here, we use RNAseq to define pre-treatment rectal gene expression, and fecal microbiota profiles, in 206 pediatric UC patients ...
Y. Haberman, Rebekah A. Karns, P. Dexheimer, M. Schirmer, Judith Somekh, I. Jurickova, T. Braun, Elizabeth A. Novak, Laura E. Bauman, M. Collins, A. Mo, M. Rosen, Erin Bonkowski, Nathan M Gotman, Alison Marquis, Mason Nistel, P. Rufo, S. Baker, Cary G. Sauer, J. Markowitz, M. Pfefferkorn, J. Rosh, B. Boyle, D. Mack, R. Baldassano, Sapana R. Shah, N. LeLeiko, M. Heyman, A. Grifiths, A. Patel, J. Noe, B. Aronow, S. Kugathasan, T. Walters, G. Gibson, S. Thomas, K. Mollen, S. Shen-Orr, C. Huttenhower, R. Xavier, J. Hyams, L. Denson   +41 more
semanticscholar   +1 more source

All Nanozyme‐Based Cascade Reactions for Biomedical Applications: from Self‐Cascading Nanozyme to Immobilized Cascade Nanozyme

Advanced Science, EarlyView.
This review introduces the development and classification of all‐nanozyme cascade reaction systems, highlighting mechanistic insights and research methods for understanding catalytic features and design principles. It provides detailed classifications, surveys recent applications in biosensing and therapy, and discusses the challenges that all‐nanozyme
Caixia Zhu, Congcong Jiang, Hian Kee Lee, Yuanjian Zhang, Sheng Tang   +4 more
wiley   +1 more source

Correction to: The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe

BMC Gastroenterology, 2021
Leonardo Ruiz-Casas, Jonathan Evans, Alison Rose, Gabriel Ghizzi Pedra, Alan Lobo, Alan Finnegan, Bu Hayee, Laurent Peyrin-Biroulet, Andreas Sturm, Johan Burisch, Helen Terry, Luisa Avedano, Seb Tucknott, Gionata Fiorino, Jimmy Limdi   +14 more
doaj   +1 more source

Research Progress on Idebenone in Neurodegenerative Diseases

AGING MEDICINE, EarlyView.
The study not only summarizes the biological properties of Idebenone (IDE), including its role in improving mitochondrial function and antioxidative stress, but also explores its clinical research progress in various neurodegenerative diseases, providing a new perspective for the treatment of these disorders.
Yanqing Zhang, Yanhong Ren, Xiaoran Zhu, Tianhao Liu, Rundong Han, Yuqing Fang, Zhangning Zhao, Fei Mao, Yalin Wang, Xian Li, Xiuhua Li   +10 more
wiley   +1 more source