Results 151 to 160 of about 471,997 (328)

Exploring the health benefits of gut microbiota metabolites on combating ulcerative colitis via network pharmacology, bioinformatics and molecular docking

Scientific Reports
Ulcerative colitis (UC) is a leading health challenge worldwide. The evidence of the benefits of gut microbiota metabolites for the treatment of ulcerative colitis is accumulating, but the underlying mechanism remains to be further elucidated. Hence, the
Weiguo Yao, Jinlin Huo, Kun Liu, Pengyu Tao   +3 more
doaj   +1 more source

β-ionone prevents dextran sulfate sodium-induced ulcerative colitis and modulates gut microbiota in mice

Food Innovation and Advances
β-ionone has various biological activities, such as anti-inflammatory, antimicrobial, and anticancer effects. The pathogenesis of ulcerative colitis is correlated with immune dysfunction, intestinal barrier damage, and gut microbiota imbalance.
Jingjing Fang, Tingting Liu, Yumeng Wang, Seong-Gook Kang, Kunlun Huang, Tao Tong   +5 more
doaj   +1 more source

Intestinal Barrier Glycosylation for Gut Physiology and Pathology

Barrier Immunity, EarlyView.
ABSTRACT The intestinal barrier is a selective structure that safeguards the body from external threats while permitting nutrient absorption and immune surveillance. It consists of the outer mucus layer, the intermediate layer of intestinal epithelial cells (IECs), and the inner layer of immune cells. The proteins in the mucus layer and within IECs are
Girak Kim, Deji Ye, Yikun Yao, Chuan Wu
wiley   +1 more source

Gut‐microbiota‐brain Axis and post‐traumatic epilepsy

Epilepsia Open, EarlyView.
Abstract There has been growing evidence that perturbations in gut‐microbiota‐brain axis (GMBA) are involved in mechanisms of chronic sequelae of traumatic brain injury (TBI). This review discusses the connection between GMBA and post‐traumatic epilepsy (PTE), the latter being a common outcome of TBI.
Andrey Mazarati
wiley   +1 more source

Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis

Exploration, EarlyView.
NaCr promotes KCr to impede the inflammatory progression of ulcerative colitis. KCr induces mitophagy by activating the PINK1/PARKIN pathway to restrict NLRP3 inflammasome activation, thereby decreasing the production and release of various inflammatory cytokines, such as IL‐1β and TNF‐α. KCr induces mitophagy and inhibits NLRP3 inflammasome activation
Tongtong Liu, Binyan Lin, Ying Zhang, Jiayu Su, Xiaochao Hu, Xuan Wang, E‐Hu Liu, Shijia Liu   +7 more
wiley   +1 more source

Lactobacillus Plantarum 6C Alleviates DSS‐Induced Colitis via Ligilactobacillus Enrichment‐Dependent Suppression of the PI3K‐AKT Signaling Pathway

Food Frontiers, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic intestinal inflammatory disease with complex pathogenesis. Previous studies have shown that probiotics alleviate UC by modulating the gut microbiome. Therefore, this study aimed to investigate the ameliorative effect of Lactobacillus plantarum 6C (L.
Jiashan Qin, Jun Guo, Tieyun Chen, Ji'an Zhang, Wuyuntana, Shaoying Ma, Xinlei Yan   +6 more
wiley   +1 more source

Spotlight commentary: Addressing the persistent problem of benzodiazepine overuse, time for clinical, educational and AI‐driven reform

British Journal of Clinical Pharmacology, EarlyView.
Jakša Vukojević, Luka Horvat, Vito Papić, Andrija Štajduhar   +3 more
wiley   +1 more source

Almond Polysaccharide Ameliorates DSS‐Induced Ulcerative Colitis in Mice by Restoring Intestinal Barrier Function and Modulating Gut Microbiota and SCFAs Metabolism

Food Frontiers, EarlyView.
This study shows that almond polysaccharide AP1 relieves DSS‐induced UC in mice by restoring the mucosal barrier, suppressing inflammation, and modulating gut microbiota and SCFA metabolism. ABSTRACT The development of new therapeutic strategies for ulcerative colitis (UC) requires the targeting of multiple pathogenic factors, including disruption of ...
Yanqi Peng, Ji Wu, Ronghua Fan, Mingyue Ma, Xixin Wang, Yuzhen Pi, Xiqing Yue, Yanyu Peng   +7 more
wiley   +1 more source

A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis. [PDF]

, 2013
ObjectiveEtrolizumab (rhuMAb β7, anti-β7, PRO145223) is a humanised monoclonal antibody targeting the β7 subunit of the heterodimeric integrins α4β7 and αEβ7, which are implicated in leucocyte migration and retention in ulcerative colitis (UC).
Baumgart, Daniel C, Bressler, Brian, Danilenko, Dimitri, Egen, Jackson, Fedorak, Richard N, Hommes, Daan W, Keir, Mary, Luca, Diana, Mansfield, John C, O'Byrne, Sharon, Rutgeerts, Paul J, Schreiber, Stefan, Sturm, Andreas, Tang, Meina, Visich, Jennifer, Wei, Xiaohui, Williams, Marna   +16 more
core  

Human Lysozyme Transgenic Maize Improves Colonic Inflammation by Inhibiting the cGAS/STING Signaling Pathway in DSS‐Induced Colitis Mice

Food Frontiers, EarlyView.
Human lysozyme (HLZ) possesses the function of ameliorating intestinal inflammation. HLZ transgenic maize restored intestinal barrier function in colitis mice. HLZ‐feed inhibited the cGAS/STING signaling pathway by ameliorating DSS‐induced mitochondrial dysfunction.
Yinuo Yu, Yaqin Li, Xuan Chen, Rentao Song, Zhenyi Qiao, Weiwei Qi   +5 more
wiley   +1 more source