Results 51 to 60 of about 471,997 (328)

Macrophage-Biomimetic Nanoparticles Ameliorate Ulcerative Colitis through Reducing Inflammatory Factors Expression

Journal of Innate Immunity, 2021
Background and Aims: Inflammatory mediator S100A9 is dramatically elevated in ulcerative colitis and correlates with disease severity. S100A9 is a potential molecule to target for the treatment of colitis, but to date, there is no effective targeting ...
Zhengshuo Li, Xiaoyue Zhang, Can Liu, Qiu Peng, Yangge Wu, Yuqing Wen, Run Zheng, Qun Yan, Jian Ma   +8 more
doaj   +1 more source

Budesonide Foam Has a Favorable Safety Profile for Inducing Remission in Mild-to-Moderate Ulcerative Proctitis or Proctosigmoiditis. [PDF]

, 2015
BackgroundBudesonide foam, a rectally administered, second-generation corticosteroid with extensive hepatic first-pass metabolism, is efficacious for the treatment of mild-to-moderate ulcerative proctitis and ulcerative proctosigmoiditis.AimThe aim of ...
Barrett, Andrew C, Bortey, Enoch, Bosworth, Brian, Forbes, William P, Golden, Pamela L, Gordon, Glenn L, Rolleri, Robert L, Rubin, David T, Sale, Mark E, Sandborn, William J, Zakko, Salam   +10 more
core   +3 more sources

Ulcerative Colitis-Diagnostic and Therapeutic Algorithms.

Deutsches Ärzteblatt International, 2020
BACKGROUND Ulcerative colitis is a chronic inflammatory bowel disease with an estimated 150 000 patients in Germany alone. METHODS This review is based on publications about current diagnostic and therapeutic strategies for ulcerative colitis that were
T. Kucharzik, S. Koletzko, K. Kannengiesser, A. Dignass   +3 more
semanticscholar   +1 more source

Disease Burden and Unmet Medical Needs in Patients with Ulcerative Colitis in Greece: A Cross-Sectional Patient Survey

Medical Sciences
Background: Ulcerative colitis (UC) requires life-long disease management. This study aimed to investigate the disease burden and unmet medical needs in UC patients in Greece.
George Gourzoulidis, Vasiliki-Rafaela Vakouftsi, George Mavridoglou, Marina Psarra, Charalampos Tzanetakos   +4 more
doaj   +1 more source

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

New Diagnostic Possibilities for Determining the Activity of Ulcerative Colitis: The Role of Neutrophils

Архивъ внутренней медицины, 2022
The incidence of ulcerative colitis has been increasing in recent years, and its manifestation at a young age has become a trend that is prognostically unfavorable.
E. V. Bolotova, K. A. Yumukyan, A. V. Dudnikova   +2 more
doaj   +1 more source

Probiotics for maintenance of remission in ulcerative colitis.

Cochrane Database of Systematic Reviews, 2020
BACKGROUND Ulcerative colitis is an inflammatory condition affecting the colon, with an annual incidence of approximately 10 to 20 per 100,000 people. The majority of people with ulcerative colitis can be put into remission, leaving a group who do not ...
Zipporah Iheozor-Ejiofor, Lakhbir Kaur, M. Gordon, Patricia Anne Baines, V. Sinopoulou, A. Akobeng   +5 more
semanticscholar   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Intestinal barrier tightening by a cell-penetrating antibody to Bin1, a candidate target for immunotherapy of ulcerative colitis. [PDF]

, 2018
Patients afflicted with ulcerative colitis (UC) are at increased risk of colorectal cancer. While its causes are not fully understood, UC is associated with defects in colonic epithelial barriers that sustain inflammation of the colon mucosa caused by ...
Alexander, Walker, Dilbarova, Rima, Gilligan, John, Hoxha, Kevther, Kossenkov, Andrew, Mullin, James M., Prendergast, George C., Thomas, Sunil, Whittaker, Kelly   +8 more
core   +2 more sources

Myeloperoxidase Luminol Reaction – A Novel Faecal Assay for Predicting Colonoscopy Findings in Patients with Ulcerative Colitis: A Pilot Cross‐Sectional Clinical Study

Advanced Healthcare Materials, EarlyView.
Can luminol detect faecal inflammation? This study explores the development and optimisation of a rapid novel assay ‐ Myeloperoxidase Luminol Reaction (MPOLR) for the detection of faecal myeloperoxidase activity. This simple and rapid luminol‐based approach competes with clinically validated faecal biomarkers in predicting endoscopic findings in ...
Viraj Kariyawasam, Taylor Davis, Mark Ghali, David Tejcek, Thomas R O'Neil, Ella Verley, Matthew Griffiths, Miguel Campos, Ingrid Bonney, Andrew C. Bulmer, Yogambha Ramaswamy, Nikola Mitrev, Crispin Corte, Paul K. Witting, Belal Chami   +14 more
wiley   +1 more source