Results 61 to 70 of about 137,392 (257)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Clinical and Laboratory Characterization of Acquired Von Willebrand Syndrome

American Journal of Hematology, EarlyView.
ABSTRACT Acquired von Willebrand Syndrome (AVWS) is a rare bleeding disorder characterized by quantitative or qualitative defects of von Willebrand factor (VWF) in patients without a personal or family history of bleeding. It is frequently associated with systemic diseases, particularly lymphoproliferative disorders (LPDs) and myeloproliferative ...
Alessandro Ciavarella, Luciano Baronciani, Omid Seidizadeh, Paola Colpani, Elio Ingenito, Daniele Cattaneo, Maria Teresa Pagliari, Addolorata Truma, Alessandra Iurlo, Simona Maria Siboni, Flora Peyvandi   +10 more
wiley   +1 more source

Eosinophil Activation in Ulcerative Colitis [PDF]

, 1994
To evaluate the activity level of eosinophils in patients with ulcerative colitis (UC), we analyzed peripheral blood eosinophil counts, serum levels of eosinophil cationic protein (ECP) and the percentage of hypodense eosinophils among all eosinophils in
Oda, Hidetoshi, Itsuno, Minoru, Makiyama, Kazuya, Kanzaki, Shinichiro, Yamasaki, Yoshiyuki   +4 more
core  

Identification and validation of fecal complement component 3 and fibronectin as potential biomarkers for monitoring disease activity in ulcerative colitis based on a mouse model

Animal Models and Experimental Medicine, EarlyView.
This study demonstrated elevated levels of fecal component 3 (C3) and fibronectin (FN) in an ulcerative colitis (UC) mouse model. Importantly, fecal C3 exhibited a stronger correlation with disease activity than the clinically used fecal calprotectin (FC).
Yangyun Guo, Ziheng Yan, Jingyu Ye, Ruifu Yang, Yajun Song, Hui Yue, Yong Zhao   +6 more
wiley   +1 more source

Infliximab in ulcerative colitis

, 2008
Avi Levin, Oren ShiboletGastroenterology and Liver Units, Division of Medicine, Hadassah-Hebrew University Medical center, Jerusalem, IsraelAbstract: Infliximab, a monoclonal anti-TNF-α antibody, is commonly used for treatment of moderate to ...
Avi Levin, Oren Shibolet
core  

Analysis of volatile marker compounds in body fluid samples from patients with gastrointestinal disease [PDF]

, 2010
Causes of gastrointestinal diseases such as ulcerative colitis (UC) Crohn’s disease (CD) and irritable bowel syndrome (IBS) are not yet completely understood and clinical investigation for diagnosis is invasive, costly and time consuming.
Fowler, Dawn P.
core  

Dietary Baicalin Supplementation Can Enhance the Growth Performance of Weaned Piglets and Maintain the Intestinal Barrier Integrity

Animal Research and One Health, EarlyView.
This research innovatively illustrates baicalin’s multifaceted mechanisms in enhancing piglets’ intestinal health: modulating bile acid metabolism via probiotics, reinforcing tight junction proteins (ZO‐1/claudin), suppressing TLR4/NF‐κB‐mediated inflammation, whereas promoting growth and reducing diarrhea.
Yuhui Gao, Jie Liu, Rui Yang, Xizhen Fan, Cheng Liang, Xin'e Shi, Jianjun Jin   +6 more
wiley   +1 more source

A rare extraintestinal manifestation of ulcerative colitis: Tracheobronchitis associated with ulcerative colitis

, 2010
We describe a 44 year-old woman who presented with dyspnea and cough 5 years after initial diagnosis of ulcerative colitis. The evaluation of patient showed findings of large airway inflammation with tracheal wall thickening and mucosal irregularities ...
Selen Bayraktaroglu, Savas, Recep, Bayraktaroglu, Selen, Tuncel, Senay, Ahmet Aydın, Basoglu, Ozen, Ceylan, Naim, Aydin, Ahmet, Recep Savas, Ozen Basoglu, Senay Tuncel, Naim Ceylan   +11 more
core   +1 more source

Spondyloarthritis Preceding and Following Inflammatory Bowel Disease Diagnosis and Risk Factors: A Temporal Trends Analysis in a Population‐Based Cohort

Arthritis &Rheumatology, EarlyView.
Objective Spondyloarthritides (SpA) and inflammatory bowel disease (IBD) are immune‐mediated diseases with overlap in clinical and immunologic features. However, temporal correlation of SpA and IBD in individual patients and risk factors are not well characterized.
Manasi Agrawal, Christian N. Sørensen, Gry J. Poulsen, Bahar Moghaddam, Percio S. Gulko, Jean‐Frederic Colombel, Tine Jess   +6 more
wiley   +1 more source

IRGM variants and susceptibility to inflammatory bowel disease in the German population. [PDF]

, 2013
Genome-wide association studies identified the autophagy gene IRGM to be strongly associated with Crohn's disease (CD) but its impact in ulcerative colitis (UC), its phenotypic effects and potential epistatic interactions with other IBD susceptibility ...
Darina Czamara, Seiderer, J., Goke, B., Eleni Tsekeri (276693), Stephanie Bues, Fries, C., Julia Seiderer (107820), Beigel, F., Glas, J., Friedrich, Matthias, Christian Steib (174731), Czamara, D., Jürgen Glas (107816), Stephanie Bues (276692), Bues, S., Eleni Tsekeri, Stallhofer, Johannes, Torsten Olszak (107835), Brand, Stephan, Florian Beigel (174724), Beigel, Florian, Matthias Friedrich (174721), Stallhofer, J., Johannes Stallhofer, Matthias Friedrich, Wetzke, M., Darina Czamara (107824), Stephan Brand (107861), Julia Diegelmann, Steib, Christian, Göke, Burkhard, Fries, Christoph, Friedrich, M., Seiderer, Julia, Glas, Jürgen, Tsekeri, E., Diegelmann, J., Burkhard Göke (109829), Christoph Fries, Martin Wetzke, Burkhard Göke, Christian Steib, Stephan Brand, Tsekeri, Eleni, Brand, S., Steib, C., Czamara, Darina, Martin Wetzke (107833), Julia Diegelmann (107830), Bues, Stephanie, Jürgen Glas, Wetzke, Martin, Diegelmann, Julia, Christoph Fries (174714), Johannes Stallhofer (174728), Torsten Olszak, Olszak, T., Florian Beigel, Julia Seiderer, Olszak, Torsten   +59 more
core   +1 more source