Results 131 to 140 of about 672,024 (402)
World Journal of Gastroenterology, 2017 Inflammatory bowel diseases (IBD), including Crohn’s disease and ulcerative colitis, are complex diseases that result from the chronic dysregulated immune response in the gastrointestinal tract.
D. Eichele, K. Kharbanda
semanticscholar +1 more source
Advanced Science, EarlyView.Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon +8 more
wiley +1 more source
IL-33 is produced by colon fibroblasts and differentially regulated in acute and chronic murine colitis [PDF]
, 2021 Amanda Waddell +3 more
openalex +1 more source
Mapping the Tissue‐of‐Origins of Mesenchymal Stromal Cells in Injury Repair
Advanced Science, EarlyView.This study maps mesenchymal stromal cells (MSCs) across multiple tissues, revealing that bone marrow–derived MSCs mobilize monocytes via CCL2 to promote systemic inflammation but do not migrate to distant organs to form fibrotic or tumor stroma. Instead, local MSCs dominate tissue remodeling, suggesting a “two‐hit” model linking systemic inflammation ...
Xinyu Thomas Tang +4 more
wiley +1 more source
Inflammatory Bowel Disease: A Canadian Burden of Illness Review
Canadian Journal of Gastroenterology, 2012 BACKGROUND: Inflammatory bowel diseases (IBD) – Crohn’s disease (CD) and ulcerative colitis (UC) – significantly impact quality of life and account for substantial costs to the health care system and society.
Angela Rocchi +8 more
doaj +1 more source
Switching from reference infliximab to CT-P13 in patients with inflammatory bowel disease: 12 months results [PDF]
, 2017 Background: Biological agents, such as infliximab, have transformed the outcomes of patients with immune-mediated inflammatory diseases. The advent of biosimilar treatment options such as CT-P13 promises to improve the availability of biological therapy,
Argüelles Arias, Federico +7 more
core
Endoplasmic reticulum stress related genome-wide Mendelian randomization identifies therapeutic genes for ulcerative colitis and Crohn’s disease [PDF]
, 2023 Menglong Zou +4 more
openalex +1 more source
Advanced Science, EarlyView.This study identifies microRNA‐10a (miR‐10a) as a key brake on regulatory T cell (Treg) suppressive function and intestinal repair. By targeting Blimp‐1, Uqcrq, and amphiregulin, miR‐10a restrains transcriptional, metabolic, and epithelial programs essential for Treg activity.
Wenjing Yang +9 more
wiley +1 more source
Oral Delivery of IL-27 Recombinant Bacteria Attenuates Immune Colitis in Mice [PDF]
, 2013 Miranda L. Hanson +10 more
openalex +1 more source
World Journal of Gastroenterology, 2009 Eosinophilic colitis (EC) is a rare form of primary eosinophilic gastrointestinal disease with a bimodal peak of prevalence in neonates and young adults. EC remains a little understood condition in contrast to the increasingly recognized eosinophilic esophagitis.
Okpara, Nnenna +2 more
openaire +3 more sources