Results 131 to 140 of about 321,837 (258)

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Short‐Term Outcomes of Transanal Total Mesorectal Excision for Rectal Cancer: A Multicenter Propensity Score‐Matched Analysis Comparing Patients With and Without Preoperative Neoadjuvant Therapy

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim To evaluate the association between preoperative neoadjuvant therapy and short‐term outcomes of transanal total mesorectal excision for rectal cancer. Methods We retrospectively analyzed patients who underwent transanal total mesorectal excision at 26 Japanese institutions between 2012 and 2019.
Takafumi Shima, Hiroki Hamamoto, Takeru Matsuda, Ichiro Takemasa, Keitaro Tanaka, Toshiki Mukai, Jun Watanabe, Sang‐Woong Lee, Seiichiro Yamamoto, Takeshi Naitoh, Ta‐Ta‐Mi Study Group Collaborators from the Japan Society of Laparoscopic Colorectal Surgery, Akihiro Kondo, Akinobu Taketomi, Akiyoshi Kanazawa, Atsushi Ogura, Chikayoshi Tani, Gunpei Yoshimatsu, Hideki Endo, Hideya Kashihara, Hirokazu Suwa, Junichiro Kawamura, Kay Uehara, Kei Kimura, Keiichi Okano, Keiichiro Okuyama, Kenji Okita, Kiyoshi Maeda, Kohei Shigeta, Koji Okabayashi, Koya Hida, Masafumi Inomata, Masahiko Watanabe, Masaji Tani, Masataka Ikeda, Masatsune Shibutani, Masayoshi Iwamoto, Masayuki Ishii, Nobuki Ichikawa, Shigenori Honma, Shinichiro Mori, Shiro Terai, Suguru Hasegawa, Takeshi Okabayashi, Takuya Tokunaga, Tatsunari Fukuoka, Tatsuya Manabe, Tatsuya Shonaka, Tomonori Akagi, Toru Kuramoto, Toru Miyake, Toshikatsu Nitta, Toshiki Mukai, Yoshihito Ide, Yosuke Fukunaga, Yuki Murata, Yukinari Tokoro, Yukitoshi Todate, Yusaku Shogen   +57 more
wiley   +1 more source

A shared mucosal gut microbiota signature in primary sclerosing cholangitis before and after liver transplantation

Hepatology, EarlyView., 2022
In this study of the gut mucosal microbiota in primary sclerosing cholangitis (PSC), we found consistent microbiota features associated with PSC and recurrent PSC, PSC with inflammatory bowel disease and a persistent gut dysbiosis after liver transplantation Abstract Background and Aims Several characteristic features of the fecal microbiota have been ...
Mikal Jacob Hole, Kristin Kaasen Jørgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer‐Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Götz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov   +12 more
wiley   +1 more source

Local Recurrence and Oncological Outcomes After Transanal Total Mesorectal Excision With Intersphincteric Resection for Lower Rectal Cancer: A Nationwide Multicenter Cohort Study (Ta‐Ta‐Mi Study)

Annals of Gastroenterological Surgery, EarlyView.
The 3‐year local recurrence (LR), recurrence‐free survival, and overall survival rates were 7.3%, 79.5%, and 98.1%, respectively. Multivariable analysis identified circumferential resection margin (CRM)/radial margin (RM) positivity as an independent risk factor for LR.
Kan Tanabe, Shinichiro Mori, Kenji Baba, Takeru Matsuda, Ichiro Takemasa, Koji Okabayashi, Chikayoshi Tani, Tatsuya Manabe, Yoshihiro Kakeji, Takao Ohtsuka, Seiichiro Yamamoto, Takeshi Naitoh, Ta‐Ta‐Mi Study Group Collaborative of the Japan Society of Laparoscopic Colorectal Surgery   +12 more
wiley   +1 more source

Research Topics in Gastrointestinal Disease: A Report on the 10th Meeting and an Announcement of the 11th Meeting

Canadian Journal of Gastroenterology, 2011
Nicola Jones, Ken Croitoru, Stephen Vanner, Rohini Soni, Louise Hope   +4 more
doaj   +1 more source

A 1-year follow-up study on checkpoint inhibitor-induced colitis : results from a European consortium

: Background: Data regarding the clinical outcome of patients with immune checkpoint inhibitor (ICI)-induced colitis are scant. We aimed to describe the 12-month clinical outcome of patients with ICI-induced colitis.
Kav, T., Corazza, G.R., Biagi, F., Kotsakis, A., Muscarella, S., Porcari, S., Santacroce, G., Savarino, E.V., Cammarota, G., Pugliese, D., Spagnuolo, R., Ellul, P., Bertani, L., Natalello, G., Barberio, B., Corallo, S., Locati, L.D., Vanoli, A., Scalvini, D., Dal Buono, A., Premoli, A., De Lisi, G., Gambini, G., Delliponti, M., Caprioli, F., Klersy, C., Eder, P., Foteinogiannopoulou, K., Agustoni, F., Schiepatti, A., Silvestris, N., Chiellino, S., Vecchi, M., Vernero, M., Groechenig, H.P., Koutroubakis, I., Demarzo, M.G., Armuzzi, A., Festa, S., Contaldo, A., Sottotetti, F., Lenti, M.V., Cuce, M., Lasagna, A., Musella, V., Pedrazzoli, P., Gabbiadini, R., De Ruvo, M., Alimenti, E., Ribaldone, D.G., Ianiro, G., Mengoli, C., Buda, A., Blesl, A., Broglio, G., Argyriou, K., Rossi, C.M., Pagani, A., Cannizzaro, R., Jauregui, Aranzazu, Cappello, M., Di Sabatino, A., Lepore, F., Aronico, N., Gasbarrini, A., Franzoi, M., Morano, D., Merli, S., de Andreis, F. Borrelli   +68 more
core  

Genotype–Phenotype Correlations of Monoallelic PFIC Variants in Pediatric Liver Disease: A Multicenter Retrospective Cohort Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Progressive familial intrahepatic cholestasis (PFIC) is classically caused by biallelic pathogenic variants, yet monoallelic variants of uncertain significance (VUS) in PFIC‐associated genes are increasingly identified in children with cholestasis, creating diagnostic uncertainty.
Brett J. Hoskins, Tiziano Pramparo, Chaowapong Jarasvaraparn, Michael J. Wilsey, Voytek Slowik, Lakshmi Kunam, Janis M. Stoll, Ruben E. Quiros‐Tejeira, Simon Lam, Wikrom Karnsakul   +9 more
wiley   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Extraintestinal Reprogramming of Colon‐Derived CD4+ Intraepithelial Lymphocytes Reveals a Mechanism Underlying the Gut–Joint Axis

Arthritis &Rheumatology, EarlyView.
Objective The gut–joint axis is a central paradigm in spondyloarthritis, yet the cellular mechanisms linking intestinal and joint immunity remain poorly understood. One potential link is T cell receptor αβ+ CD4+ colon intraepithelial lymphocytes (cIELs) that can traffic to extraintestinal tissues, including the joint.
Sarah M. Danielson, Connor Eck, Sucai Liu, Anna Helena Jonsson, Kristine A. Kuhn   +4 more
wiley   +1 more source

Oral vancomycin solution is superior to capsule in inducing clinical biomarker and endoscopic remission in children with atypical ulcerative colitis

British Journal of Clinical Pharmacology, EarlyView.
Aims Atypical colitis (presenting reverse gradient colitis, backwash ileitis or rectal sparing) is associated with primary sclerosing cholangitis–ulcerative colitis (PSC). Oral vancomycin has been used to manage paediatric atypical colitis with/without confirmed PSC. Different preparations had shown different efficacy.
Laura Räisänen, Fariha Balouch, Claire Reilly, Christopher Burgess, Peter Lewindon   +4 more
wiley   +1 more source