Results 151 to 160 of about 199,144 (206)

Homozygosity for a variant in SLC10A2 and infancy onset severe fat‐soluble vitamin deficiency due to bile acid malabsorption

JPGN Reports, EarlyView.
Abstract We present a case of a young female patient with persistent and severe fat‐soluble vitamin deficiency since infancy. Despite extensive investigations during childhood, the underlying cause remained elusive. The patient was generally asymptomatic while receiving continuous vitamin subsidy.
Christine Rungoe, Stefan Stender, Nawar Dalila, Emil D. Bartels, Christian Jakobsen   +4 more
wiley   +1 more source

Hematochezia: An abnormal presenting symptom of an extensive vascular malformation in a 6‐year‐old boy

JPGN Reports, EarlyView.
Abstract Gastrointestinal (GI) bleeding can be a common symptom in the pediatric population. Vascular malformations, which cause symptoms based on their location and effect on surrounding structures, are an uncommon cause of GI bleeding. We present the case of a 6‐year‐old male with a 1‐year history of hematochezia, constipation, and microcytic anemia.
Kathleen Ordas, Joy Brusenback, Sahana Ummadi, Shannon Tocchio, Razan Alkhouri, Soha Shah   +5 more
wiley   +1 more source

Eosinophilic mesenteric vasculitis presenting as inflammatory bowel disease

JPGN Reports, EarlyView.
Abstract Inflammatory bowel disease (IBD), including Crohn's Disease (CD) and ulcerative colitis, is a chronic inflammatory condition affecting the gastrointestinal tract. Treatment for IBD depends on disease severity and can include medical and surgical management.
Razan Alkhouri, Craig Wong, Allyson Richards, David Martin, Joshua Hanson, Rasha Elmaoued, Rajmohan Dharmaraj, Ioannis Kalampokis   +7 more
wiley   +1 more source

Impact of biologic induction dose and concomitant drugs on anti‐drug antibody formation in a pediatric IBD cohort with high Hispanic representation

JPGN Reports, EarlyView.
Abstract Objectives The use of biologic therapy is increasing in pediatric patients with inflammatory bowel disease (IBD). However, efficacy may be compromised by increased drug clearance and anti‐drug antibodies (ADAs). Historically, concomitant immunomodulator therapy (CIT) has been used to prevent ADA formation. Pediatric studies evaluating CIT have
Kenneth Grant, Jenilee Pohle, Robert Tran, Roy Nattiv   +3 more
wiley   +1 more source

Synchronous Melanoma: A Single‐Centre 5‐Year Retrospective Study

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Synchronous melanoma (SM) is defined as ≥ 2 melanomas diagnosed at the same time, or within 3 months of diagnosing the first melanoma, and occurs rarely. Objectives The objective of this study was to review all the cases of SM discussed at the melanoma MDT meeting in our cancer centre over the last 5 years.
Ji Fung Yong, Michael O'Connell, Alana Durack, Lyndsey Paul   +3 more
wiley   +1 more source

Monotropein Induced Ferroptosis to Alleviate the Progression of Hepatocellular Carcinoma via Regulating Nrf2/HO‐1/GPX4 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) exhibits a high global morbidity rate and ranks as the fourth leading cause of cancer‐related mortality worldwide. In response to the urgent need for effective HCC treatments, naturally occurring, botanical‐driven compounds have gained increasing attention.
Bing Shi, Yan‐Ping Li, Zhuo Gan, Pan Chen   +3 more
wiley   +1 more source

Investigating the Impact of hsa_circ_0005255 on Proliferation and Autophagy in Crohn's Disease Intestinal Epithelial Cells Through miR‐23a‐3p‐Mediated NCOA3 Expression

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Crohn's Disease (CD), an inflammatory bowel disorder, is influenced by genetic, immune, and environmental factors. The present study highlights the pioneering role of circular RNAs (circRNAs) in the etiology of CD, with a specific focus on hsa_circ_0005255 and its regulatory role.
Dong Liu, De‐Run Kong
wiley   +1 more source

Cannabinoids and the Endocannabinoid System in the Treatment of Chronic Rhinosinusitis

The Laryngoscope, EarlyView.
The objective of this scoping review is to explore the role of the ECS in the pathophysiology of CRS. We identified five studies, all supporting a common conclusion that the ECS is implicated in regulating cellular inflammatory pathways potentially involved in sinonasal disease.
John J. W. Lee, Amr F. Hamour, Jacob G. J. Wihlidal, John M. Lee, Eric Monteiro, Ewa Poduch, Lakshmi Kotra, Allan D. Vescan   +7 more
wiley   +1 more source

Liver Disease Predicts 30‐Day Postoperative Complications in Head and Neck Microvascular Surgery

The Laryngoscope, EarlyView.
While liver disease is known to affect surgical outcomes, its impact on head and neck microvascular free tissue transfer surgeries remains unexamined. This study uses the NSQIP national database to analyze the relationship between liver disease severity, determined by APRI and MELD‐Na scores, and postoperative complications.
Anish R. Kosanam, James R. Xu, Khashayar Arianpour, Danielle Bottalico, Eric D. Lamarre   +4 more
wiley   +1 more source

Combining Selective Laser Sintering and Fused Deposition Modeling of Pharmaceutical Polymers: A Novel Approach to Prepare Intestine‐Targeted Tablets

Macromolecular Materials and Engineering, EarlyView.
Selective laser sintering (SLS) and fused deposition modeling (FDM) are combined to prepare intestine‐targeted tablets with controlled drug release. The SLS‐printed core contains a model drug. The FDM‐printed coating shell modifies drug release and increases tablet mechanical resistance.
Thao Tranová, Kevin Matzick, Jan Loskot, Jana Macháčková, Marie Nevyhoštěná, Oliver Macho, Vladimíra Trnčáková, Alena Komersová, Jitka Mužíková   +8 more
wiley   +1 more source