The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice. [PDF]
, 2013 The specific inhibition of phosphodiesterase (PDE)4 and dual inhibition of PDE3 and PDE4 has been shown to decrease inflammation by suppression of pro-inflammatory cytokine synthesis.
A Hatzelmann +43 more
core +3 more sources
Neural Network-Based Histologic Remission Prediction In Ulcerative Colitis [PDF]
arXiv, 2023 BACKGROUND & AIMS: Histological remission (HR) is advocated and considered as a new therapeutic target in ulcerative colitis (UC). Diagnosis of histologic remission currently relies on biopsy; during this process, patients are at risk for bleeding, infection, and post-biopsy fibrosis.
arxiv
Anemia, 2015 Current iron supplementation practice in geriatric patients is erratic and lacks evidence-based recommendations. Despite potential benefits in this population, intravenous iron supplementation is often withheld due to concerns regarding pharmacy expense,
Matthias Bach +6 more
doaj +1 more source
Noninfectious Colitides: Collagenous Colitis, Lymphocytic Colitis, Diversion Colitis, and Chemically Induced Colitis [PDF]
Clinics in Colon and Rectal Surgery, 2007 Approximately 10% of patients with chronic diarrhea carry a diagnosis of microscopic colitis. The endoscopic appearance of both collagenous colitis and lymphocytic colitis may be normal; however, biopsies confirm the diagnosis. Available treatments include antidiarrheals, bismuth salicylate, and budesonide.
openaire +3 more sources
Role of the protein annexin A1 on the efficacy of anti-TNF treatment in a murine model of acute colitis [PDF]
, 2016 TNF-α is involved in the mechanisms that initiate inflammatory bowel diseases (IBDs). Anti-TNF-α drugs, such as infliximab (IFX), cause non-responsiveness and side effects, indicating the need to investigate alternative therapies for these diseases.
Barrios, Bibiana Elisabet +6 more
core +1 more source
Current Research in Pharmacology and Drug Discovery, 2022 The number of available biological therapies have doubled over the last 10 years and the arrival of novel molecules (interleukin 23p19 inhibitors) is ongoing alongside the development of small molecules.
Pascal Juillerat +5 more
doaj
CMV in the gut: a critical review of CMV detection in the immunocompetent host with colitis. [PDF]
, 2015 As scientific techniques for the detection of cytomegalovirus (CMV) improve, we are able to detect small amounts of CMV in the mucosal wall. As clinicians, we are unsure how to interpret the results of this novel test.
Goodman, AL +4 more
core +1 more source
The Establishment of a National Tissue Bank for Inflammatory Bowel Disease Research in Canada
Canadian Journal of Gastroenterology, 2003 The Crohn’s and Colitis Foundation of Canada (CCFC) has established a national bank for tissue, serum and blood from patients with inflammatory bowel disease (IBD).
Stephen M Collins +3 more
doaj +1 more source
Colitis isquémica. Colitis microscópica
Medicine - Programa de Formación Médica Continuada Acreditado, 2016 Resumen Introduccion. La colitis isquemica y la colitis microscopica son entidades de muy diferente naturaleza, manejo y pronostico, pero afectan con mayor frecuencia y de forma similar a mujeres mayores de 60 anos. Patogenia. Manifestaciones clinicas.
S. Parejo +3 more
openaire +2 more sources
Vedolizumab as induction and maintenance therapy for ulcerative colitis.
New England Journal of Medicine, 2013 BACKGROUND Gut-selective blockade of lymphocyte trafficking by vedolizumab may constitute effective treatment for ulcerative colitis. METHODS We conducted two integrated randomized, double-blind, placebo-controlled trials of vedolizumab in patients ...
B. Feagan +15 more
semanticscholar +1 more source