Results 81 to 90 of about 321,837 (258)

Pathogenesis of Microscopic Colitis: A Systematic Review

, 2022
Background: Whereas the exact aetiology of microscopic colitis [MC] remains unknown, a dysregulated immune response to luminal factors or medications is the most accepted pathogenesis hypothesis.Methods: We conducted a systematic review of the ...
Lucendo, Alfredo J.,, Zabana, Yamile, Fernández-Bañares, Fernando, Latella, Giovanni, Latella, Giovanni,, Marlicz, Wojciech, Elisabeth Østvik, Ann,, Tontini, Gian, Tontini, Gian,, Skonieczna-Żydecka, Karolina,, Fernández-Bañares, Fernando,, Arias, Angel, Münch, Andreas, Hultgren Hörnquist, Elisabeth,, Østvik, Ann Elisabeth,, Østvik, Ann Elisabeth, Zabana, Yamile,, Arias, Angel,, Lucendo, Alfredo J, D'Amato, Mauro,, Skonieczna-Żydecka, Karolina, Mielhke, Stephan,, Mielhke, Stephan, Münch, Andreas,, DAmato, Mauro,, D'Amato, Mauro, Marlicz, Wojciech,, Hultgren-Hörnquist, Elisabeth,, Hultgren-Hörnquist, Elisabeth, Zabana, Y, Munch A., D'Amato M., Hultgren-Hornquist E., Tontini, G, Latella, G, Tontini G., Fernandez-Banares F., Mielhke, S, Latella G., Lucendo A. J., Zabana Y., Ostvik A. E., Elisabeth, Ostvik A, Arias, A, Skonieczna-Zydecka K., D'Amato, M, Mielhke S., Skonieczna-Zydecka, K, Marlicz W., Arias A., Hultgren-Hornquist, E, Marlicz, W   +51 more
core   +1 more source

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK‐Binding Osteoclastogenic Factor

Advanced Science, EarlyView.
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park, Yeongkag Kwon, Yeonjin Lim, Jeong Woo Park, Hyun Jung Ji, Dongwook Lee, Jueun Lee, Sung‐Ho Yun, Sungho Jeong, Ho Seong Seo, Kun Cho, Cheol‐Heui Yun, Ok‐Jin Park, Seung Hyun Han   +13 more
wiley   +1 more source

Psychological distress is highly prevalent in inflammatory bowel disease: A survey of psychological needs and attitudes

JGH Open, 2020
Background and Aim Data on patient needs and access to psychological services in inflammatory bowel disease (IBD) are scarce. This study aimed to describe the levels of distress and the needs, attitudes, and access to psychological services for people ...
Antonina Mikocka‐Walus, Wayne Massuger, Simon R Knowles, Gregory T Moore, Stephanie Buckton, William Connell, Paul Pavli, Leanne Raven, Jane M Andrews   +8 more
doaj   +1 more source

The intra-individual variability of faecal calprotectin: A prospective study in patients with active ulcerative colitis

, 2015
Leukocyte-derived proteins in faeces, especially calprotectin, are increasingly used to assess disease activity in ulcerative colitis. The objectives of the present study were to assess the importance of factors related to the stool sampling ...
Sapnara, Maria,, Stotzer, Per-Ove,, Strid, Hans,, Isaksson, Stefan,, Öhman, Lena,, Lasson, Anders   +5 more
core   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

Identifying robust biomarkers for the diagnosis and subtype distinction of inflammatory bowel disease through comprehensive serum metabolomic profiling

Scientific Reports
Inflammatory Bowel Disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC), requires a combination of procedures and tests in diagnosis and discrimination.
Ji Eun Kim, Dong Ho Suh, Yu Jin Park, Chi Hyuk Oh, Shin Ju Oh, Hyeji Kang, Yosep Ji, Young Jin Kim, Weon Kim, Eun Sung Jung, Chang Kyun Lee   +10 more
doaj   +1 more source

Germ-free and Antibiotic-treated Mice are Highly Susceptible to Epithelial Injury in DSS Colitis [PDF]

, 2016
Background and Aims: Intestinal microbiota is required to maintain immune homeostasis and intestinal barrier function. At the same time, intraluminal bacteria are considered to be involved in inflammatory bowel disease and are required for colitis ...
Zarzuelo Zurita, Antonio, Sánchez De Medina López-Huertas, Fermín, Capitán Cañadas, Fermín, Suárez Ortega, María Dolores, Martínez Augustín, María Olga, Aranda, Carlos J., Hernández Chirlaque, Cristina, Ortega González, Mercedes, Ocón, Borja, Capitan-Canadas, F, Zarzuelo, A, Ocon, B, Dolores, Suarez M, Jesus, Carrero J, Sanchez, de Medina F, Martinez-Augustin, O, Aranda, CJ, Ortega-Gonzalez, M, Hernandez-Chirlaque, C   +18 more
core   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Patterns and Predictors of Steroid Use in a Real‐World Inflammatory Bowel Disease Cohort

JGH Open
Background Patterns of steroid use in inflammatory bowel disease remain poorly characterized in real‐world settings. Steroid exposure is associated with adverse effects and often indicates suboptimally controlled disease.
Rodger Wu, Consuelo Rivas, Wai Kin Su, Renée Deschenes, William Wilson, Joseph L. Pipicella, Susan J. Connor, Jane M. Andrews, the Crohn's Colitis Cure (CCCure) Data Insights Program   +8 more
doaj   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source