Results 101 to 110 of about 321,837 (258)

INSIGHTS INTO THE ROLE OF INFLAMMATION IN COLITIS-ASSOCIATED CANCER: TARGETING TUMOR NECROSIS FACTOR RECEPTORS

, 2011
Inflammatory bowel diseases (IBD) are associated with an elevated risk of colorectal cancer that increases with disease duration and severity. Tumor necrosis factor (TNF) is a major therapeutic target in IBD, but long-term anti-TNF therapy is associated ...
Stillie, RoseMarie
core  

The Syk Inhibitor Fostamatinib Decreases the Severity of Colonic Mucosal Damage in a Rodent Model of Colitis [PDF]

, 2015
BACKGROUND AND AIMS: Inflammatory bowel disease is a chronic inflammatory disease of the gastrointestinal system. In some cases, current medications used for inflammatory bowel disease may not be enough for remission, creating a need for more potent and ...
Kurt, Mevlut, Aksit, Hasan, Yilmaz, Bulent, Demirtaş, Selim, Can, Guray, Korkmaz, Ugur, Karaca, Turan, Ayvaz, Süleyman, Can, Hatice, Yılmaz, Bülent   +9 more
core   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Multifunctional Zinc Glycyrrhizinate‐Integrated Gel for Enhanced Probiotic Delivery and Alleviation of Acute and Spontaneous Colitis

Advanced Science, EarlyView.
Multifunctional oral delivery system—L. reuteri@ZGM—act as both a carrier and therapeutic adjuvant, providing ROS scavenging, and mucin‐interactive properties tailored to the IBD microenvironment. This bioactive gel safeguards L. reuteri from gastric degradation, enhances mucosal adhesion, and promotes long‐term retention at inflamed sites, thereby ...
Mengyun Peng, Xiaochun Chen, Wei Li, Shu Tang, Jun Zhou, Xia Wu, Dan Yuan, Zhongyan Shan, Junfeng Shi   +8 more
wiley   +1 more source

Local Interactions Between Innate Immune Signaling, Microbiota, and Bile Acids Drive the Development of Duodenal AdenomasSummaryWhat You Need to Know

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Duodenal adenomas have malignant potential, yet the drivers of duodenal tumorigenesis remain unclear. Duodenal adenomas robustly develop in villin- Toll-like receptor 4 (TLR4) mice, a transgenic mouse model of increased innate ...
Juan F. Burgueño, Hajar Hazime, Julia Fritsch, Gillian E. Jacobsen, Henry D. Dione, Trevor Cickovski, Eddy E. González, Ana M. Santander, Irina Fernández, Nivis Brito, Zhen Gao, Yuguang Ban, Lily Wang, Landon Wilson, Stephen Barnes, Judith Pignac-Kobinger, Mark S. Sundrud, Maria T. Abreu   +17 more
doaj   +1 more source

Inhibitory effect of spleen X-ray irradiation on dextran sulfate sodium-induced colitis in the mouse [PDF]

, 1994
Dextran sulfate sodium (DSS) solution was orally administered to mice to experimentally induce colitis, and the effects of X-ray irradiation of the spleen on healing or prolongation of inflammation was investigated.
Senju, Masahiro, Makiyama, Kazuya, Umene, Yoshihiko   +2 more
core  

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

ECCO Guidelines on Therapeutics in Ulcerative Colitis: Surgical Treatment.

This is the second of two articles presenting the European Crohn's and Colitis Organisation [ECCO] evidence‑based consensus guidelines on the management of adult patients with ulcerative colitis [UC]. The first article covers the medical management of UC,
Kucharzik, Torsten, Leong, Rupert W, Verstockt, Bram, Fantini, Massimo Claudio, Holubar, Stefan, Chaparro, María, Reenaers, Catherine, Schmidt, Carsten, Allocca, Mariangela, El-Hussuna, Alaa, Greuter, Thomas, Stassen, Laurents P S, Adamina, Michel, Caprioli, Flavio, Myrelid, Pär, Bettenworth, Dominik, Blumenstein, Irina, Uzzan, Mathieu, Casanova, María José, Brown, Steven R, Atreya, Raja, Barreiro-De Acosta, Manuel, Battat, Robert, Noor, Nurulamin M, Burke, John P, Kienle, Peter, Furfaro, Federica, Pouillon, Lieven, Saibeni, Simone, Avellaneda, Nicolas, Minozzi, Silvia, Ellul, Pierre, Kopylov, Uri, Visser, Eva, De Buck Van Overstraeten, Anthony, Kapizioni, Christina, Eder, Piotr, Doherty, Glen, Papaconstantinou, Ioannis, Christou, Niki, Limdi, Jimmy K, Peros, Georgios, Hazel, Karl, Leventoglu, Sezai, Sousa, Paula, Vieujean, Sophie, Gisbert, Javier P   +46 more
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Fecal chromogranins and secretogranins are increased in patients with ulcerative colitis but are not associated with disease activity

, 2013
Little is known of the importance of chromogranins (Cg) and secretogranins (Sg) in ulcerative colitis (UC). We therefore investigated fecal levels of CgA, CgB, SgII and SgIII, and their association with inflammatory activity, disease duration and medical
Lasson, Anders,, Strid, Hans,, Isaksson, Stefan,, Simrén, Magnus,, Stridsberg, Mats, Öhman, Lena,   +5 more
core   +1 more source