Results 21 to 30 of about 1,484,513 (388)
Collagen structure and stability.
Annual Review of Biochemistry, 2009 Collagen is the most abundant protein in animals. This fibrous, structural protein comprises a right-handed bundle of three parallel, left-handed polyproline II-type helices.
M. Shoulders, Ronald T. Raines
semanticscholar +1 more source
Nature Communications, 2020 Tumor extracellular matrix has been associated with drug resistance and immune suppression. Here, proteomic and RNA profiling reveal increased collagen levels in lung tumors resistant to PD-1/PD-L1 blockade.
D. Peng +15 more
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Journal of Medical Case Reports, 2018 Background TAFRO syndrome, which was first reported in 2010 in Japan, is a relatively rare disease characterized by thrombocytopenia, anasarca, fever, renal impairment, reticulin fibrosis, and organomegaly.
Yu Fujiwara +3 more
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Immune Modulatory Properties of Collagen in Cancer
Frontiers in Immunology, 2021 During tumor growth the extracellular matrix (ECM) undergoes dramatic remodeling. The normal ECM is degraded and substituted with a tumor-specific ECM, which is often of higher collagen density and increased stiffness.
A. Rømer +2 more
semanticscholar +1 more source
Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix [PDF]
, 2015 Despite the crucial role of extracellular matrix (ECM) in directing cell fate in healthy and diseased tissues--particularly in development, wound healing, tissue regeneration and cancer--the mechanisms that direct the assembly and regulate hierarchical ...
Gourdon, Delphine +7 more
core +2 more sources
Collagens and collagen-related diseases
Annals of Medicine, 2001 The collagen superfamily of proteins plays a dominant role in maintaining the integrity of various tissues and also has a number of other important functions. The superfamily now includes more than 20 collagen types with altogether at least 38 distinct polypeptide chains, and more than 15 additional proteins that have collagen-like domains.
Kari I. Kivirikko, Johanna Myllyharju
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Environmental Health Perspectives, 1984 Collagen is the major structural protein of the lung. At least five genetically distinct collagen types have been identified in lung tissue. However, the precise role of collagen in nonrespiratory lung function is not well understood, in part because of the difficulties inherent in studying lung collagen, regardless of the type of assay used.
Last, JA, Reiser, KM
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Materials & Design, 2023 Although biomimetic scaffolds have been constructed to repair critical-size bone defects, the creation of composite scaffolds that can mimic the anisotropy of natural bone remains a major challenge.
Huixia He +5 more
doaj
3D bioprinting of collagen-based materials for oral medicine
Collagen and Leather, 2023 Oral diseases have emerged as one of the leading public health challenges globally. Although the existing clinical modalities for restoration of dental tissue loss and craniomaxillofacial injuries can achieve satisfactory therapeutic results, they cannot
Bosen Yang +9 more
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Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta. [PDF]
, 1994 A hallmark of systemic sclerosis (SSc) is the development of tissue fibrosis. Excessive production of several connective tissue components normally present in the dermis, including type I, III, V, and VI collagens as well as fibronectin and proteoglycans,
Christiano, Angela M. +5 more
core +3 more sources