Results 71 to 80 of about 642,400 (224)
Collagen microarchitecture mechanically controls myofibroblast differentiation. [PDF]
, 2020 Altered microarchitecture of collagen type I is a hallmark of wound healing and cancer that is commonly attributed to myofibroblasts. However, it remains unknown which effect collagen microarchitecture has on myofibroblast differentiation.
Andresen Eguiluz, Roberto Carlos +12 more
core
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Multimodal optical characterisation of collagen photodegradation by femtosecond infrared laser ablation. [PDF]
, 2014 Collagen is a structural component of the human body, as a connective tissue it can become altered as a result of pathophysiological conditions. Although the collagen degradation mechanism is not fully understood, it plays an important role in ageing ...
Bozec, L +6 more
core +1 more source
FEBS Open Bio, EarlyView.We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang +9 more
wiley +1 more source
Plastic compression of collagen: development and assessment of a new biomaterial in nerve repair [PDF]
, 2005 Nerve reconstruction is a surgical challenge. Current neural conduits provide sub-optimal clinical results. We have developed a device from a composite material comprising a fibronectin core and a collagen outer layer, using collagen made by a new ...
Ashraff, S, Brown, R.A., Phillips, J.B.
core
FEBS Open Bio, EarlyView.Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui +15 more
wiley +1 more source
3D Raman mapping of the collagen fibril orientation in human osteonal lamellae [PDF]
, 2014 Chemical composition and fibrillar organization are the major determinants of osteonal bone mechanics. However, prominent methodologies commonly applied to investigate mechanical properties of bone on the micro scale are usually not able to concurrently ...
Galvis, L. +4 more
core +2 more sources
Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification
FEBS Open Bio, EarlyView.Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski +13 more
wiley +1 more source
Applied Sciences, 2020 Scaffolds are thought to be a key element needed for successful cartilage repair treatments, and this prospective extension study aimed to evaluate long-term structural and clinical outcomes following osteochondral defect treatment with a cell-free ...
Agnes Berta +9 more
doaj +1 more source
Collagen-hyaluronic acid scaffolds for adipose tissue engineering. [PDF]
, 2010 Three-dimensional (3-D) in vitro models of the mammary gland require a scaffold matrix that supports the development of adipose stroma within a robust freely permeable matrix. 3-D porous collagen-hyaluronic acid (HA: 7.5% and 15%) scaffolds were produced
Cameron, RE +4 more
core +2 more sources