Results 81 to 90 of about 1,537,139 (389)

Teflon Injection into the Trachea Causes Predictable Fibroblastic Response and Collagen Deposition: A Pilot Study. [PDF]

, 2016
BackgroundExpiratory central airway collapse is an increasingly recognized abnormality of the central airways and may be present in as many as 22% of patients evaluated for chronic obstructive pulmonary disease and/or asthma.
Baxter, Boiselle, Bolliger, Bolot, Chertin, Chertin, Dedo, Eisner, Ernst, Ernst, Feist, Ferguson, Fujiwara, Gilkeson, Ikeda, Iwamoto, Johnson, Jokinen, Jokinen, Kirchner, Lehman, Majid, Murgu, Noppen, Nuutinen, Palombini, Susanto, Wright, Zhang   +28 more
core   +1 more source

Collagen as Bioink for Bioprinting: A Comprehensive Review

International Journal of Bioprinting, 2020
Biomaterials made using collagen are successfully used as a three-dimensional (3D) substrate for cell culture and considered to be promising scaffolds for creating artificial tissues.
Egor O. Osidak, V. Kozhukhov, M. S. Osidak, S. Domogatsky   +3 more
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Effect of composite collagen containing hydrogel on the functional activity of fibroblasts after acid-induced in vitro injury

Acta Biomedica Scientifica
It is well known that the acidity of the microenvironment has a significant impact on the functional activity of cells involved in tissue repair. To date, the effect of biomaterials containing components of the human dermis intercellular matrix on ...
P. A. Markov, P. S. Eremin, I. R. Gilmutdinova, A. I. Greben, E. Yu. Kostromina, А. S. Sokolov, I. A. Artemyeva   +6 more
doaj   +1 more source

Recombinant Collagen Engineered to Bind to Discoidin Domain Receptors Functions as a Receptor Inhibitor [PDF]

, 2015
A bacterial collagen-like protein Scl2 has been developed as a recombinant collagen model system to host human collagen ligand-binding sequences, with the goal of generating biomaterials with selective collagen bioactivities.
Abbonante, V, An, B, Balduini, A, Bihan, D, Brodsky, B, Farndale, RW, Gavriilidou, D, Kaplan, D, Leitinger, B, Xu, H, Yoshizumi, A   +10 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

A highly durable and biocompatible bionic collagen implant with exceptional anti-calcification and collagen regeneration capabilities for improved skin rejuvenation

Materials & Design
Skin aging, a complex and inevitable biological process, considerably impacts an individual’s physical appearance and overall well-being. While collagen-based implants hold potential for skin rejuvenation, their clinical application is limited by the ...
Qi Wang, Huiyu Yan, Linyan Yao, Wenhua Li, Jianxi Xiao   +4 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Evidence for diversifying selection of genetic regions of encoding putative collagen-like host-adhesive fibers in Pasteuria penetrans [PDF]

, 2019
© FEMS 2018. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided ...
Anderson, Andrews, Arohi Srivastava, Arslan, Atibalentja, Aziz, Carver, Charles, Cohan, Colson, Davies, Davies, Davies, Davies, Davies, Davies, Degnan, DePristo, Duan, Dutta, Eardly, Espanol, Felsenstein, Filée, Gascuel, Giblin-Davis, Giblin-Davis, Huynen, Jones, Kanehisa, Kaufman, Keith G Davies, Kumar, Legendre, Luijckx, Luijckx, Maddison, Mauchline, McElroy, Metchnikoff, Mohan, Mohan, Mouton, Murtagh, Noel, Philippe, R Developement Core Team, Radó-Trilla, Rajendhran, Romero, Rutherford, Sayre, Sayre, Schouls, Sharad Mohan, Sharma, Stackebrandt, Starr, Steichen, Stirling, Stirling, Sturhan, Sylvestre, Sylvestre, Tamura, Tim H Mauchline, Todd, Wiedenbeck, Woese, Yap, Zilversmit   +70 more
core   +3 more sources

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source