Results 51 to 60 of about 346,226 (309)

Ablation of integrin-mediated cell–collagen communication alleviates fibrosis [PDF]

, 2023
Objectives Activation of fibroblasts is a hallmark of fibrotic processes. Besides cytokines and growth factors, fibroblasts are regulated by the extracellular matrix environment through receptors such as integrins, which transduce biochemical and ...
Evy Lundgren-Akerlund, Koester, J., Nava, Michele M., Michele M Nava, Wickström, Sara, Wang, F., Koester, Janis, Eckes, Beate, Fang Wang, Sawant, Mugdha, Sara Wickström, Wickström, S., Nava, Michele M, Gullberg, D., Leitinger, B., Niehoff, Anja, Beate Eckes, Leitinger, Birgit, Sawant, M., Lundgren-Akerlund, E., Lundgren-Akerlund, Evy, Mugdha Sawant, Krieg, T., Niehoff, A., Janis Koester, Wang, Fang, Nava, M., Donald Gullberg, Gullberg, Donald, Krieg, Thomas, Wickstroem, Sara, Birgit Leitinger, Thomas Krieg, Eckes, B., Anja Niehoff   +34 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The role of collagen in joint disorders: Applications in orthopedics, rheumatology, and sports medicine

Quality in Sport
Joint diseases are prevalent in orthopedic, rheumatological, and sports medicine fields, significantly impacting patients' quality of life. Collagen, a primary component of connective tissues, has emerged as a therapeutic agent for these conditions ...
Maria Wojcieszek, Julia Szałajska, Natalia Wierzejska, Mikołaj Domański, Barbara Kopczyńska, Oliwia Czyżniewska, Karolina Czupryńska, Karina Otręba   +7 more
doaj   +1 more source

Matrix Metalloproteinase Mediated Type I Collagen Degradation — An Independent Risk Factor for Mortality in Women

EBioMedicine, 2015
Chronic fibro-proliferative diseases are associated with nearly 45% of all deaths in the developed world. Matrix metalloproteinase (MMP) mediated remodeling of the extracellular matrix (ECM) plays an important role in disease development.
K. Dragsbæk, J.S. Neergaard, H.B. Hansen, I. Byrjalsen, P. Alexandersen, S.N. Kehlet, A.-C. Bay-Jensen, C. Christiansen, M.A. Karsdal   +8 more
doaj   +1 more source

Collagen VIII in vascular diseases. [PDF]

Collagens have dual functions in the extracellular matrix (ECM), acting as both structural components and signaling molecules in matricellular communication.
Li, Qian, Tintut, Yin, Demer, Linda, Bendeck, Michelle, Vazquez-Padron, Roberto, Vazquez-Padron, Roberto I., Bendeck, Michelle P., Hsu, Jeffrey J., Hsu, Jeffrey, Demer, Linda L.   +9 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

eLife
Collagen-I fibrillogenesis is crucial to health and development, where dysregulation is a hallmark of fibroproliferative diseases. Here, we show that collagen-I fibril assembly required a functional endocytic system that recycles collagen-I to assemble ...
Joan Chang, Adam Pickard, Jeremy A Herrera, Sarah O'Keefe, Richa Garva, Matthew Hartshorn, Anna Hoyle, Lewis Dingle, John Knox, Thomas A Jowitt, Madeleine Coy, Jason Wong, Adam Reid, Yinhui Lu, Cédric Zeltz, Rajamiyer V Venkateswaran, Patrick T Caswell, Stephen High, Donald Gullberg, Karl E Kadler   +19 more
doaj   +1 more source

Blue sclera and osteogenesis imperfecta - A rare association

Kerala Journal of Ophthalmology, 2017
The sclera is a dense poorly vascularized connective tissue structure composed of Types I, III, IV, V, VI, and VIII collagen. The characteristic blue sclera is caused by thinness and transparency of the collagen fibers of the sclera that allow ...
Sujit Das, Kavita Bhatnagar
doaj   +1 more source

Collagen of Dupuytren's Disease

Clinical Science, 1977
1. In contrast to collagen from the aponeurosis of normal adult subjects, the nodules, contractures and apparently unaffected aponeurosis from patients with Dupuytren's disease contained substantial amounts of type III collagen. 2. The presence of type III collagen supports the previous proposal that the initial response to injury is the
Bailey, A. J., Sims, T. J., Gabbiani, G., Bazin, S., Lelous, M.   +4 more
openaire   +3 more sources