Results 51 to 60 of about 333,763 (263)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Acquired perforating dermatosis in the setting of hepatocellular carcinoma

JAAD Case Reports, 2021
Reinaldo Tovo Filho, MD, PhD, Silmara da Costa Pereira Cestari, MD, PhD, Isabella Zurita Dehó, MD, Reinaldo Falavigna Tovo, PhD, Gabriela Franco Marques, MD, PhD, Ivana Diniz Lírio, MD, Mariana Petaccia de Macedo, MD   +6 more
doaj   +1 more source

Functionalized collagen-based biomaterials via self-assembly: implications for gastrointestinal health

Collagen and Leather
Collagen, one of the most abundant proteins in human physiology, maintains the morphology and structure of skin and tissues, serving as an important raw material for the repair of damaged tissues.
Qin Ma, Yuanmeng He, Yunxiang He, Yue Wu, Qinling Liu, Yulin Guan, Lie Yang, Junling Guo   +7 more
doaj   +1 more source

Cardiac involvement in collagen diseases

European Heart Journal, 1995
The purpose of this study is to evaluate the early morphological and functional abnormalities of the heart in patients with collagen disease. The study population was free of risk factors for coronary artery disease and without any clinically evident cardiac manifestations.
TOUMANIDIS, ST, PAPAMICHAEL, CM, ANTONIADES, LG, PANTELIA, MI, SARIDAKIS, NS, MAVRIKAKIS, ME, SIDERIS, DA, MOULOPOULOS, SD   +7 more
openaire   +4 more sources

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Collagen deposition in lung parenchyma driven by depletion of interstitial Lyve-1+ macrophages prevents cigarette smoke-induced emphysema and loss of airway function

Frontiers in Immunology
IntroductionCollagen is essential for maintaining lung structure and function and its remodeling has been associated with respiratory diseases including chronic obstructive pulmonary disease (COPD).
Yinebeb Mezgebu Dagnachew, Yinebeb Mezgebu Dagnachew, Yinebeb Mezgebu Dagnachew, Hwee Ying Lim, Hwee Ying Lim, Liao Wupeng, Liao Wupeng, Sheau Yng Lim, Sheau Yng Lim, Sheng Jie Natalie Lim, Sheng Jie Natalie Lim, Chung Hwee Thiam, Chung Hwee Thiam, Shu Wen Tan, Shu Wen Tan, Joan Lau Joo Eng, Joan Lau Joo Eng, Dan Mei, Syaza Hazwany Mohammad Azhar, Wei Siong Ong, Qi Hui Caris Tan, Wai-Shiu Fred Wong, Wai-Shiu Fred Wong, Wai-Shiu Fred Wong, Veronique Angeli, Veronique Angeli   +25 more
doaj   +1 more source

Plasma membrane overgrowth causes fibrotic collagen accumulation and immune activation in Drosophila adipocytes

eLife, 2015
Many chronic diseases are associated with fibrotic deposition of Collagen and other matrix proteins. Little is known about the factors that determine preferential onset of fibrosis in particular tissues.
Yiran Zang, Ming Wan, Min Liu, Hongmei Ke, Shuangchun Ma, Lu-Ping Liu, Jian-Quan Ni, José Carlos Pastor-Pareja   +7 more
doaj   +1 more source

Developing an Injectable Nanofibrous Extracellular Matrix Hydrogel With an Integrin αvβ3 Ligand to Improve Endothelial Cell Survival, Engraftment and Vascularization

Frontiers in Bioengineering and Biotechnology, 2020
Endothelial cell (EC) transplantation via injectable collagen hydrogel has received much attention as a potential treatment for various vascular diseases.
Dake Hao, Dake Hao, Ruiwu Liu, Kewa Gao, Kewa Gao, Chuanchao He, Siqi He, Siqi He, Cunyi Zhao, Gang Sun, Diana L. Farmer, Diana L. Farmer, Alyssa Panitch, Alyssa Panitch, Kit S. Lam, Aijun Wang, Aijun Wang, Aijun Wang   +17 more
doaj   +1 more source

Facial cosmetic therapy use amongst patients with systemic sclerosis: an Australian cohort study

Arthritis Care &Research, Accepted Article.
Objective Systemic sclerosis (SSc) is associated with numerous facial manifestations for which patients may engage in cosmetic therapies. It is unclear how patients with SSc use these therapies. This study sought to characterise patient engagement and experiences with cosmetic therapies for SSc‐related and non‐SSc‐related facial changes.
Zachary Warren, Diane Apostolopoulos, Gene‐Siew Ngian, Amanda M Saracino, Laura Ross, Nava Ferdowsi, Jennifer Walker, Cindy Hall, Kim Griggs, Susanna Proudman, Wendy Stevens, Joanne Sahhar   +11 more
wiley   +1 more source

Lysyl Oxidase Reduces Neutrophil Extravasation in Response to P. aeruginosa in an Infection‐on‐a‐Chip Model

Advanced NanoBiomed Research
Neutrophils are crucial players in the fight against infections. Unfortunately, dysregulated neutrophil function contributes to the pathogenesis of diseases, including cancer, fibrosis, and atherosclerosis, that leave those afflicted vulnerable to severe
Christopher J. Calo, Tanvi Patil, Josephine Fouts, Eric L. Ginter, Margaret Radke, Hannah K. Weppner, Justin M. Owens, Laurel E. Hind   +7 more
doaj   +1 more source