Results 41 to 50 of about 514,386 (288)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Beyond classical collagen: basement membrane collagen IV in age-associated lung diseases
European Respiratory ReviewChronic lung diseases such as COPD, asthma, idiopathic pulmonary fibrosis (IPF) and pulmonary hypertension are characterised by aberrant remodelling and degradation of the extracellular matrix.
Natalia El-Merhie +3 more
doaj +1 more source
Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. [PDF]
, 2017 BACKGROUND: Central nervous system tuberculosis (CNS-TB) may be fatal even with treatment. Neutrophils are the key mediators of TB immunopathology, and raised CSF matrix metalloproteinase-9 (MMP-9) which correlates to neutrophil count in CNS-TB is ...
Brilha, S +6 more
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Materials Today BioThe accurate detection of multiplex collagen biomarkers is vital for diagnosing and treating various critical diseases such as tumors and fibrosis. Despite the attractive optical properties of quantum dots (QDs), it remains technically challenging to ...
Xiangdong Cai +7 more
doaj +1 more source
Fluorescent spectroscopy of collagen as a diagnostic tool in medicine
Journal of Medical Science, 2022 Medicine continuously needs to improve the existing diagnostic solutions or introduce new ones. Despite the fact that collagen is a well described protein, collagen-related diseases represent the disorders requiring improvement particularly in terms of ...
Łukasz Saletnik, Roland Wesołowski
doaj
PLoS ONE, 2017 Dysregulation of collagen production contributes to various pathological processes, including tissue fibrosis as well as impaired wound healing.
Yoolhee Yang +4 more
doaj +1 more source
γδTCR regulates production of interleukin-27 by neutrophils and attenuates inflammatory arthritis. [PDF]
, 2018 γδ T cells have been implicated in inflammatory diseases as an important link between the innate and adaptive immune responses, however, their role in inflammatory arthritis remain unclear.
Adamopoulos, Iannis E +3 more
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Endostatin in Renal and Cardiovascular Diseases
Kidney Diseases, 2021 Endostatin, a protein derived from the cleavage of collagen XVIII by the action of proteases, is an endogenous inhibitor known for its ability to inhibit proliferation and migration of endothelial cells, angiogenesis, and tumor growth.
Mei Li +4 more
doaj +1 more source