Results 31 to 40 of about 346,226 (309)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

ES-62 protects against collagen-induced arthritis by resetting interleukin-22 towards resolution of inflammation in the joints [PDF]

, 2014
Objective. The parasitic worm–derived immunomodulator ES-62 protects against disease in the mouse collagen-induced arthritis (CIA) model of rheumatoid arthritis (RA) by suppressing pathogenic interleukin-17 (IL-17) responses. The Th17 associated cytokine
Al-Riyami, Lamyaa, Pineda, Miguel A, Rodgers, David T, Harnett, Margaret M., Harnett, Margaret, Miguel A. Pineda, Lamyaa Al‐Riyami, Harnett, William, Rodgers, David T., David T. Rodgers, Margaret M. Harnett, Pineda, Miguel A., William Harnett   +12 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Collagen-immobilized polyimide membranes for retinal pigment epithelial cell adherence and proliferation

, 2017
Degenerative retinal diseases are a leading cause of visual loss and irreversible blindness, particularly in the developed world. Retinal pigment cell (RPE) transplantation is nowadays considered the most promising therapeutic approach for certain ...
Minna Kellomäki, Shokoufeh Teymouri, Anni Sorkio, Heli Skottman, Kati Juuti-Uusitalo (187668), Kati Juuti-Uusitalo, Anni Sorkio (830829), Maria Teresa Calejo, Shokoufeh Teymouri (3814690), Minna Kellomäki (3814687), Maiju Hiltunen (3814693), Maiju Hiltunen, Maria Teresa Calejo (3814684), Heli Skottman (61007)   +13 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Thoracic Manifestations of Collagen Vascular Diseases

, 2012
Collagen vascular diseases are a diverse group of immunologically mediated systemic disorders that often lead to thoracic changes. the collagen vascular diseases that most commonly involve the lung are rheumatoid arthritis, progressive systemic sclerosis,
Capobianco, Julia [UNIFESP], Grimberg, Alexandre [UNIFESP], Jasinowodolinski, Dany [UNIFESP], Meirelles, Gustavo de Souza Portes [UNIFESP], Thompson, Bruna M. [UNIFESP], Antunes, Viviane Baptista [UNIFESP]   +5 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Simultaneous fingerprinting of multiplex collagen biomarkers in connective tissues by multicolor quantum dots-based peptide probes

Materials Today Bio
The accurate detection of multiplex collagen biomarkers is vital for diagnosing and treating various critical diseases such as tumors and fibrosis. Despite the attractive optical properties of quantum dots (QDs), it remains technically challenging to ...
Xiangdong Cai, Bo Wang, Linge Nian, Tao Cheng, Chunxia Zhang, Lu Li, Guangrui Zhang, Jianxi Xiao   +7 more
doaj   +1 more source

Fluorescent spectroscopy of collagen as a diagnostic tool in medicine

Journal of Medical Science, 2022
Medicine continuously needs to improve the existing diagnostic solutions or introduce new ones. Despite the fact that collagen is a well described protein, collagen-related diseases represent the disorders requiring improvement particularly in terms of ...
Łukasz Saletnik, Roland Wesołowski
doaj