Results 61 to 70 of about 2,661,550 (300)
In Situ Genetic Engineering Facilitates MMP-9-Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing. [PDF]
Adv Sci (Weinh)This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Zhang Y +11 more
europepmc +2 more sources
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
GelsCollagen is a versatile material, and collagen in the human body strengthens the muscles and related organs, allowing good substances to be absorbed into the bloodstream while preventing the absorption of toxic substances. Thus, collagen has been broadly
Yugyung Lee, Chi H. Lee
doaj +1 more source
Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway [PDF]
, 2003 Background: The regulation of platelet function by pharmacological agents that modulate platelet signaling haspharmacolo proven a successful approach to the prevention of thrombosis.
Cicmil, M +23 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Current treatment strategies: Collagen vascular diseases in children
Indian Journal of Dermatology, 2012 Of the various collagen vascular diseases seen in pediatric age group, discoid lupus erythematosus, systemic lupus erythematosus, neonatal lupus erythematosus, juvenile dermatomyositis and childhood scleroderma are common and of practical importance to ...
Aparna Palit, Arun C Inamadar
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Role of collagen in oral and systemic diseases
SRM Journal of Research in Dental Sciences, 2019 Collagen has been studied appreciably by a massive variety of researchers since 20th century. It is the most important fibrous glycoprotein among the ground substances and forms the core component within the connective tissue structures such as tendons ...
Amol Jain +2 more
doaj +1 more source
The regulation of type I collagen gene expression in stromal fibroblast by breast tumour cells [PDF]
, 2011 Includes abstract.Includes bibliographical references (leaves 110-135).Recent studies have revealed that interactions between tumour cells and the surrounding stroma play an important role in facilitating tumour growth and invasion.
Rose, Beverley Ann
core +1 more source
Radiocarbon reservoir effects in human bone collagen from northern Iceland [PDF]
, 2012 Human bone collagen from a series of Icelandic human pagan graves was radiocarbon (14C) dated to aid understanding of early settlement (landnám) chronologies in northern Iceland. These individuals potentially consumed marine protein.
Dugmore, A.J. +8 more
core +1 more source