Results 241 to 250 of about 8,720,014 (305)

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Extravascular distribution of factor IX-review of experimental and clinical evidence, and relevance for hemophilia B replacement therapy. [PDF]

Res Pract Thromb Haemost
Hermans C, Escuriola Ettingshausen C, Laffan M, Matino D, O'Connell N, Sidonio RF, Ljung R.   +6 more
europepmc   +1 more source

Basement membrane turnover controls cell shape. [PDF]

Cell
Barrientos R, Meadowcroft B, Sánchez-Sánchez BJ, Stramer BM, Paluch EK, Charras G, Banerjee S, Šarić A, Mao Y.   +8 more
europepmc   +1 more source

Lambda restricted light chain as pathogenic cause of POEMS syndrome: a review of the hypothesis. [PDF]

Front Immunol
Troutman R, Wagner A, Delery E.
europepmc   +1 more source

Extracellular matrix biomarkers of T-cell infiltration and tumor fibrosis predict response to nivolumab ± ipilimumab with SBRT in biliary tract cancer: insights from the CheckPAC trial. [PDF]

BMC Med
Rasmussen MB, Chen IM, Johansen JS, Theile S, Markussen A, Christensen TD, Karsdal MA, Willumsen N.   +7 more
europepmc   +1 more source

Monocyte-Derived LGMN⁺ Macrophages Divert Lung Injury Outcomes toward Fibrosis through Matrix Remodeling. [PDF]

Research (Wash D C)
Li Z, Zhang Y, Yang K, Zheng D, Chen Y, Zhang Y, Pan X, Yan P, Rosas IO, Yu G, Wang L.   +10 more
europepmc   +1 more source

Age-dependent vascular and neurological characteristics of CADASIL are recapitulated in Notch3 mutant zebrafish, implicating a role for type IV collagen in disease progression. [PDF]

Acta Neuropathol Commun
Kanoh T, Oubayashi S, Furukawa K, Fujimoto K, Inoue A, Mizoguchi T, Yamaguchi M, Takahashi-Nakaguchi A, Hasegawa Y, Ohara O, Aoki I, Itoh M.   +11 more
europepmc   +1 more source

Biological functions of type IV collagen

Biological functions of type IV collagen
openaire   +1 more source

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Type-IV collagen related diseases

Journal of Nephrology, 2003
  Alport syndrome (ATS) is a progressive inherited glomerulonephritis accounting for 1-2% of all patients who start renal replacement therapy, with an estimated gene frequency of approximately 1 in 5000. ATS is a genetically heterogeneous disease, commonly inherited as an X-linked semi-dominant trait, caused by mutations in COL4A5, on
PESCUCCI C., LONGO I., BRUTTINI M., MARI F., RENIERI A.   +4 more
openaire   +3 more sources