Results 251 to 260 of about 8,720,014 (305)
Some of the next articles are maybe not open access.
Difference in interaction of fibronectin with type I collagen and type IV collagen
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1997In our studies on fibronectin, difference in binding to type I collagen and type IV collagen was observed and analysed. Four different fragments, which consist of I6-II1-II2-I7-I8-I9, I6-II1-II2-I7, I6-II1-II2, and I8-I9 within the collagen binding domain, have been isolated from proteolytic digests of fibronectin.
M, Shimizu +3 more
openaire +2 more sources
Binding domain for laminin on type IV collagen
Biochemical and Biophysical Research Communications, 1985Binding of type IV collagen to laminin was studied by attaching one member of the ligand pair to a solid phase. When laminin was bound to a solid phase, type IV collagen exhibited saturable binding. Digestion of type IV collagen with high concentrations of pepsin destroyed the laminin binding activity.
C N, Rao, I M, Margulies, L A, Liotta
openaire +2 more sources
The life cycle of type IV collagen
Matrix BiologyType IV collagen is a large triple helical molecule that forms a covalently cross-linked network within basement membranes (BMs). Type IV collagen networks play key roles in mechanically supporting tissues, shaping organs, filtering blood, and cell signaling.
Sandhya Srinivasan, David R. Sherwood
openaire +2 more sources
Collagen type IV in epithelial tumours of colon
Acta Histochemica, 2002Collagen type IV in the lamina propria mucosae is one of the main components of the basement membrane of normal and transitional colon mucosa. The aim of the present study was to assess the use of anti-collagen type IV antibodies in the evaluation of biological activity of epithelial tumours of the colon.
Stefan, Galbavý +8 more
openaire +2 more sources
Basement membrane (type IV) collagen
Matrix Biology, 1995The collagen IV molecule is 400 nm long and consists of two alpha 1 (IV) and one alpha 2 (IV) chains. Their genes COL4A1 and COL4A2 form a transcription unit in which they are arranged head-to-head and connected by a short common promoter region. Recently, four additional genes have been discovered.
openaire +2 more sources
A nonradioactive assay for type IV collagen degradation
Analytical Biochemistry, 1990A sensitive assay for type IV collagen degradation using an avidin-biotin sandwich technique is described. Biotinylated type IV collagen is allowed to bind to an avidin-coated microtiter plate. The solution to be assayed is incubated with the biotinylated collagen bound to the avidin plate.
M J, Wilkinson, R L, Cohen, M A, Shuman
openaire +2 more sources
The Involvement of Type IV Collagen in Goodpasture's Syndromea
Annals of the New York Academy of Sciences, 1985Goodpasture's syndrome, involving lung and kidney, is considered to be caused by autoantibodies to basement membranes. This paper has described the isolation and identification of the antigen, which is isolated from collagenase digests of glomerular basement membrane, as a monomer protein of 26,000 daltons and two dimers of about 50,000 daltons ...
J, Wieslander, D, Heinegård
openaire +2 more sources
Type IV collagenase and immunostaining of type IV collagen in human thyroid tumors
Auris Nasus Larynx, 2000Required stages in the processes of malignant tumor invasion and metastasis are known to include the destruction of cell stroma and vascular basement membrane. It has been suggested that type IV collagenase can degrade type IV collagen, a main component of basement membrane.
T, Kusunoki +5 more
openaire +2 more sources
The presence of EC collagen and type IV collagen in bovine Descemet's membranes
Biochemical and Biophysical Research Communications, 1983When bovine Descemet's membranes (DMs) were characterized after limited pepsinization the major component in DM was found to be endothelial cell (EC) collagen. Phenol extractions of the undigested pepsin residue recovered only type IV collagen. This study provides evidence that EC collagen may be produced by corneal endothelial cells in vivo.
U, Labermeier, M C, Kenney
openaire +2 more sources
Type IV collagen and diabetic kidney disease
Nature Reviews Nephrology, 2019A new genome-wide association study of patients with type 1 diabetes mellitus reveals novel loci that are associated with the development of diabetic kidney disease. The most significant of these loci encodes the α3 chain of type IV collagen, which is an important component of the glomerular basement membrane.
openaire +2 more sources