Results 31 to 40 of about 140,913 (263)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Relationship between Lipid Indices, Type IV Collagen Turnover and the Development of Microvascular Complications in Diabetic Patients with Arterial Hypertension

Folia Medica, 2019
Background and aims: An important factor in the development of vascular wall lesions is the degradation of the major protein of connective tissue - type IV collagen.
Nikolov Asparuh, Tzekova Maria, Blazhev Alexander   +2 more
doaj   +1 more source

Assessment of urinary type IV collagen, alpha-1 microglobulin, and transferrin in type 2 diabetes mellitus with nephropathy

Journal of Medicine in Scientific Research, 2020
Aim The aim of this study was to assess the levels of urinary type IV collagen, alpha-1 microglobulin, and transferrin as risk factors for early detection of nephropathy progression in diabetic patients. Patients and methods Four groups (25 patients each)
Mohamed H Mahfouz, Mohamed S Shoman, Marwa E Hassan   +2 more
doaj   +1 more source

Long-term results of splenomegaly after surgery for biliary atresia in the native liver

Asian Journal of Surgery, 2022
Background: Biliary atresia (BA) is a rare disorder characterized by obstructive jaundice in infants, shortly after birth. Postoperatively, some patients exhibit portal hypertension and progressive liver fibrosis.
Shunsuke Watanabe, Tatsuya Suzuki, Tomonori Tsuchiya, Yasuhiro Kondo   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Effect of Aerobic Exercise on Collagen Type I and IV Gene Expression and Collagen Type I Protein Changes in the Sciatic Nerve of Diabetic Rats

Novelty in Biomedicine, 2020
Background: Neuropathy is one of the complications of diabetes, probably due to the destruction of the extracellular matrix and the thickening of the peripheral nerve basement membrane.
Nahid Jalilian Hamed, Reza Gharakhanlou, Maghsoud Peeri   +2 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Collagen mRNA levels changes during colorectal cancer carcinogenesis

BMC Cancer, 2009
Background Invasive growth of epithelial cancers is a complex multi-step process which involves dissolution of the basement membrane. Type IV collagen is a major component in most basement membranes.
Tveit Kjell M, Lothe Inger MB, Anthonsen Dorit, Skovbjerg Hanne, Kure Elin H, Vogel Lotte K   +5 more
doaj   +1 more source

The Function of the NC1 Domains in Type IV Collagen [PDF]

Journal of Biological Chemistry, 1995
At its C terminus, the collagen IV molecule bears a globular NC1 domain, to which two functions have been assigned. In the macromolecular network of collagen IV, two molecules are connected via their NC1 domains, which form a hexameric complex, stabilized by intermolecular disulfide bonds.
A, Ries, J, Engel, A, Lustig, K, Kühn
openaire   +2 more sources