Results 241 to 250 of about 7,552,757 (294)

The tumor microenvironment of cutaneous squamous cell carcinoma in high-risk patient groups: A scoping review. [PDF]

JID Innov
Wang W, Harrs C, Bolling MC, Horváth B, Diercks GFH, Rácz E.   +5 more
europepmc   +1 more source

Identification of Ferro-Aging-Related Biomarkers for Ulcerative Colitis Through Integrated Machine Learning, Single-Cell Analysis, and Spatial Transcriptomics. [PDF]

FASEB J
Wang Q, Wang N, Yan H, Yuan J.
europepmc   +1 more source

Pruritic eruption on the extremities: Report of 2 generations treated with dupilumab. [PDF]

JAAD Case Rep
Hosking AM, Saeed L, Smith J.
europepmc   +1 more source

Breaching the Blood-Brain Interface: Vasoactive Neurons Contact Capillary Vessels of the Brain Clock in the Suprachiasmatic Nucleus. [PDF]

eNeuro
Yao Y, Cannava I, Tazebay R, Samuels S, Silverstein E, Silver R.   +5 more
europepmc   +1 more source

Restoring type VII collagen in skin

Med, 2022
New therapeutic hope is emerging for people with the rare inherited blistering skin disease recessive dystrophic epidermolysis bullosa (RDEB). Gurevich et al.1 have reported early-phase clinical trial data evaluating a topical herpes simplex virus 1 vector to restore missing type VII collagen in RDEB skin and heal wounds.
Lwin, Su M., McGrath, John A.
openaire   +4 more sources

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Molecular biology and pathology of type VII collagen*

Experimental Dermatology, 1992
Abstract Type VII collagen is a genetically distinct member of the collagen family of proteins. Type VII collagen has been shown to be the major component of anchoring fibrils, attachment complexes which secure the cutaneous basement membrance of the skin to the underlying dermis. Understanding of the structure of type VII collagen has been advanced by
Jouni Uitto
exaly   +3 more sources

The vWFA2 domain of type VII collagen is responsible for collagen binding

Biochemical and Biophysical Research Communications, 2013
Type VII collagen (Col7) is the major component of anchoring fibrils and very important for skin integrity. This is emphasized by the Col7 related skin blistering diseases dystrophic epidermolysis bullosa and epidermolysis bullosa acquisita. Structural data that provides insights into the interaction network of Col7 and thus providing a basis for a ...
Karsten Seeger
exaly   +3 more sources

Type VII collagen is a component of cylindroma basement membrane zone

Journal of Cutaneous Pathology, 1989
Cylindroma basement membranes (BMs) were studied by electron microscopy and immunofluorescence with antibodies to Types IV and VII collagen in order to correlate the ultrastructure with the biochemical characteristics. Type IV collagen served as a marker for lamina densa structures and Type VII collagen for the anchoring fibrils. Ultrastructurally, the
Pfaltz M, Bruckner-Tuderman L, Schnyder UW   +2 more
openaire   +4 more sources

Immune reactivity to type VII collagen: implications for gene therapy of recessive dystrophic epidermolysis bullosa

Gene Therapy, 2010
International audienceRecessive dystrophic epidermolysis bullosa (RDEB) is a severe genodermatosis caused by loss-of-function mutations in COL7A1 encoding type VII collagen, the component of anchoring fibrils.
Matthias Titeux, Jose E Mejia, Catherine Prost-Squarcioni   +2 more
exaly   +2 more sources

Type VII Collagen in the Human Accommodation System: Expression in Ciliary Body, Zonules, and Lens Capsule [PDF]

Investigative Ophthalmology and Visual Science, 2018
To investigate intraocular expression of COL7A1 and its protein product type VII collagen, particularly at the accommodation system. Eyes from 26 human adult donors were used.
Bart Wullink, Hendri H. Pas, Leonoor Los
exaly   +3 more sources