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Effects of the WNT signaling pathway on inflammation and fibrosis in idiopathic pulmonary fibrosis: Clinical, radiological and molecular evaluation. [PDF]
Exp Ther MedKaya İ +6 more
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Laminin 5 Binds the NC-1 Domain of Type VII Collagen [PDF]
Journal of Cell Biology, 1997 Mutational analyses of genes that encode components of the anchoring complex underlying the basolateral surface of external epithelia indicate that this structure is the major element providing for resistance to external friction. Ultrastructurally, laminin 5 (α3β3γ2; a component of the anchoring filament) appears as a thin filament bridging the ...
Patricia Rousselle +2 more
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Molecular biology and pathology of type VII collagen*
Experimental Dermatology, 1992Abstract Type VII collagen is a genetically distinct member of the collagen family of proteins. Type VII collagen has been shown to be the major component of anchoring fibrils, attachment complexes which secure the cutaneous basement membrance of the skin to the underlying dermis. Understanding of the structure of type VII collagen has been advanced by
Jouni Uitto, Angela M Christiano
exaly +3 more sources
Gene Therapy, 2010 International audienceRecessive dystrophic epidermolysis bullosa (RDEB) is a severe genodermatosis caused by loss-of-function mutations in COL7A1 encoding type VII collagen, the component of anchoring fibrils.
Matthias Titeux +2 more
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The vWFA2 domain of type VII collagen is responsible for collagen binding
Biochemical and Biophysical Research Communications, 2013Type VII collagen (Col7) is the major component of anchoring fibrils and very important for skin integrity. This is emphasized by the Col7 related skin blistering diseases dystrophic epidermolysis bullosa and epidermolysis bullosa acquisita. Structural data that provides insights into the interaction network of Col7 and thus providing a basis for a ...
Karsten Seeger
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Journal of Autoimmunity, 2010 In different autoimmune diseases, tissue damage is mediated by the Fc portion of autoantibodies. These include autoimmunity to type VII collagen, a major hemidesmosomal skin constituent, where autoantibodies activate both complement and leukocytes ...
Andreas Recke +2 more
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Biochimie, 2018 Recessive dystrophic epidermolysis bullosa (RDEB) is a severe blistering disease resulting from a lack of type VII collagen production. Recent clinical trials have shown efficacy of bone marrow-derived mesenchymal stem cells (BM-MSCs) in the treatment of
Jeffrey D Mcbride +2 more
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Assay and Drug Development Technologies, 2018 Type VII collagen is the main component of the anchoring fibrils connecting the basement membrane to the underlying interstitial matrix. Mutations in the type VII collagen gene cause dystrophic epidermolysis bullosa. Increased levels of type VII collagen
Jannie M B Sand +2 more
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Laminins, tenascin and type VII collagen in colorectal mucosa
The Histochemical Journal, 1996The distribution of different laminin polypeptides, type VII collagen and tenascin has been studied in adult and foetal colorectal mucosa by using the indirect immunofluorescence technique. Immunoreactivity for laminin alpha 1 chain was located to basement membranes of epithelia, muscularis mucosae, and blood vessels, respectively in different segments
J, Lohi +6 more
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