Results 1 to 10 of about 23,489 (224)

Type XVII collagen coordinates proliferation in the interfollicular epidermis [PDF]

eLife, 2017
Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa.
Mika Watanabe, Ken Natsuga, Wataru Nishie, Yasuaki Kobayashi, Giacomo Donati, Shotaro Suzuki, Yu Fujimura, Tadasuke Tsukiyama, Hideyuki Ujiie, Satoru Shinkuma, Hideki Nakamura, Masamoto Murakami, Michitaka Ozaki, Masaharu Nagayama, Fiona M Watt, Hiroshi Shimizu   +15 more
doaj   +4 more sources

Anti-idiotypic Antibodies against BP-IgG Prevent Type XVII Collagen Depletion [PDF]

Frontiers in Immunology, 2017
Bullous pemphigoid (BP) mainly targets type XVII collagen (COL17). Intravenous immunoglobulin (IVIg) is used to treat numerous autoimmune diseases, including BP. The major mechanism of action for IVIG is thought to be its immunomodulatory effect. However,
Mayumi Kamaguchi, Mayumi Kamaguchi, Hiroaki Iwata, Yuiko Mori, Ellen Toyonaga, Hideyuki Ujiie, Yoshimasa Kitagawa, Hiroshi Shimizu   +7 more
doaj   +4 more sources

Recombinant Humanized Collagen Type XVII Promotes Oral Ulcer Healing via Anti-Inflammation and Accelerate Tissue Healing [PDF]

Journal of Inflammation Research
Yukai Hao,1 Baoling Zhao,1 Dongchao Wu,1 Xuejun Ge,1 Jianmin Han2 1Department of Endodontics, Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001 ...
Hao Y, Zhao B, Wu D, Ge X, Han J
doaj   +2 more sources

Bullous Pemphigoid Develops Independently of DAP12 [PDF]

Biomolecules
The adaptor molecule DNAX-activating protein of 12 kDa (DAP12) is broadly expressed in innate immune cells, but its role in autoimmunity remains unclear due to its dual regulatory functions.
Manuela Pigors, Sabrina Patzelt, Maëlys Brudey, Shirin Emtenani, Stanislav Khil’chenko, Mayumi Kamaguchi, Niklas Reichhelm, Melissa Parker, Katja Bieber, Ralf J. Ludwig, Enno Schmidt   +10 more
doaj   +2 more sources

Recombinant Humanized Collagen Enhances Secreted Protein Levels of Fibroblasts and Facilitates Rats’ Skin Basement Membrane Reinforcement [PDF]

Journal of Functional Biomaterials
Collagen and its peptides exhibit remarkable antioxidant activity, superior biocompatibility, and water solubility, making them a significant research focus in skin care.
Shijia Ye, Boyu Chen, Lakshmi Jeevithan, Haoze Yang, Yaqi Kong, Xiaozhen Diao, Wenhui Wu   +6 more
doaj   +2 more sources

Collagen turnover biomarkers to predict outcome of patients with biliary cancer [PDF]

BMC Gastroenterology
Background The collagen-rich tumor stroma plays a crucial role in biliary tract cancer (BTC). Collagen biomarkers of type I collagen (reC1M), type III collagen (PRO-C3), type IV collagen (C4G), type VIII collagen (PRO-C8), type XI collagen (PRO-C11 ...
Leonard Kaps, Muhammed A. Genc, Markus Moehler, Stephan Grabbe, Jörn M. Schattenberg, Detlef Schuppan, Rasmus Sund Pedersen, Morten A. Karsdal, Philipp Mildenberger, Annett Maderer, Nicholas Willumsen   +10 more
doaj   +2 more sources

Physicochemical characterization, cellular bioactivity, and biosafety evaluation of type A recombinant humanized collagen type XVII

Journal of Applied Biomaterials & Functional Materials
Collagen type XVII is a unique transmembrane protein that plays a crucial role in anchoring epithelial cells to the underlying basement membrane. However, the low natural abundance of collagen type XVII in the human body poses significant challenges for ...
Nana Han, Xingxing Gao, Lu Song, Jian Wang, Ling Li, Kaixuan Guo, Huan Hu, Jing Wang, Bo Fan, Yun Zhu, Xia Yang   +10 more
doaj   +2 more sources

Levels of type XVII collagen (BP180) ectodomain are elevated in circulation from patients with multiple cancer types and is prognostic for patients with metastatic colorectal cancer

BMC Cancer, 2023
Background Collagens are the major components of the extracellular matrix (ECM) and are known to contribute to tumor progression and metastasis. There are 28 different types of collagens each with unique functions in maintaining tissue structure and ...
Marina Crespo-Bravo, Jeppe Thorlacius-Ussing, Neel I. Nissen, Rasmus S. Pedersen, Mogens K. Boisen, Maria Liljefors, Astrid Z. Johansen, Julia S. Johansen, Morten A. Karsdal, Nicholas Willumsen   +9 more
doaj   +1 more source

Pterostilbene and Its Glucoside Induce Type XVII Collagen Expression [PDF]

Natural Product Communications, 2017
The glycosylation of pterostilbene by cultured plant cells of Phytolacca americana gave pterostilbene 4′- O-β-D-glucoside. Both pterostilbene and its 4- O-β-D-glucoside induced type XVII collagen expression in the EpiDermFT EFT-400 human skin cell model.
Hiroki, Hamada, Kei, Shimoda, Yoshiyuki, Horio, Tsubasa, Onoa, Ryusuke, Hosoda, Noriyuki, Nakayama, Koichi, Uranod   +6 more
openaire   +2 more sources

Cloning of Hamster Type XVII Collagen cDNA, and Pathogenesis of Anti-Type XVII Collagen Antibody and Complement in Hamster Bullous Pemphigoid [PDF]

Journal of Investigative Dermatology, 2002
Bullous pemphigoid is an inflammatory subepidermal blistering skin disease associated with an IgG autoimmune response to the type XVII collagen. The immunopathologic features of bullous pemphigoid can be reproduced in mice by the passive transfer of anti-type XVII collagen antibodies.
Yamamoto, Katsushi, Inoue, Naokazu, Masuda, Riako, Fujimori, Akira, Saito, Toshiyuki, Imajoh-Ohmi, Shinobu, Shinkai, Hiroshi, Sakiyama, Hisako   +7 more
openaire   +2 more sources