Results 1 to 10 of about 7,163,146 (192)

Type XVII collagen coordinates proliferation in the interfollicular epidermis [PDF]

eLife, 2017
Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa.
Mika Watanabe, Ken Natsuga, Wataru Nishie, Yasuaki Kobayashi, Giacomo Donati, Shotaro Suzuki, Yu Fujimura, Tadasuke Tsukiyama, Hideyuki Ujiie, Satoru Shinkuma, Hideki Nakamura, Masamoto Murakami, Michitaka Ozaki, Masaharu Nagayama, Fiona M Watt, Hiroshi Shimizu   +15 more
doaj   +6 more sources

Morphological abnormalities in the ureter of type XVII collagen–deficient mice [PDF]

Scientific Reports
Non-fibrillar type XVII collagen (COL17A1) is a hemidesmosomal component of the epidermis and a key skin-disease molecule. We previously reported that COL17A1 is expressed in the urothelium of multiple species at low constitutive or in inducible levels ...
Amy Suzui, Takashi Namba, Masaya Hiraishi, Sao Oe, Shunnosuke Kira, Yuki Otani, Rui Zhong, Ken Natsuga, Osamu Ichii   +8 more
doaj   +3 more sources

Levels of type XVII collagen (BP180) ectodomain are elevated in circulation from patients with multiple cancer types and is prognostic for patients with metastatic colorectal cancer [PDF]

BMC Cancer, 2023
Background Collagens are the major components of the extracellular matrix (ECM) and are known to contribute to tumor progression and metastasis. There are 28 different types of collagens each with unique functions in maintaining tissue structure and ...
Marina Crespo-Bravo, Jeppe Thorlacius-Ussing, Neel I. Nissen, Rasmus S. Pedersen, Mogens K. Boisen, Maria Liljefors, Astrid Z. Johansen, Julia S. Johansen, Morten A. Karsdal, Nicholas Willumsen   +9 more
doaj   +2 more sources

Type XVII collagen: Relevance of distinct epitopes, complement-independent effects, and association with neurological disorders in pemphigoid disorders [PDF]

Frontiers in Immunology, 2022
Pemphigoid diseases (PD) are autoimmune skin blistering diseases characterized by autoantibodies directed against proteins of the cutaneous basement membrane zone (BMZ).
Bianca Opelka, Enno Schmidt, Enno Schmidt, Stephanie Goletz   +3 more
doaj   +2 more sources

Anti-idiotypic Antibodies against BP-IgG Prevent Type XVII Collagen Depletion [PDF]

Frontiers in Immunology, 2017
Bullous pemphigoid (BP) mainly targets type XVII collagen (COL17). Intravenous immunoglobulin (IVIg) is used to treat numerous autoimmune diseases, including BP. The major mechanism of action for IVIG is thought to be its immunomodulatory effect. However,
Mayumi Kamaguchi, Mayumi Kamaguchi, Hiroaki Iwata, Yuiko Mori, Ellen Toyonaga, Hideyuki Ujiie, Yoshimasa Kitagawa, Hiroshi Shimizu   +7 more
doaj   +2 more sources

Immune Reaction to Type XVII Collagen Induces Intramolecular and Intermolecular Epitope Spreading in Experimental Bullous Pemphigoid Models [PDF]

Frontiers in Immunology, 2019
Bullous pemphigoid (BP), the most common autoimmune blistering disease, is induced by autoantibodies to type XVII collagen (COL17). Previous studies demonstrated that COL17 harbors several epitopes targeted by autoreactive T and B cells and that the ...
Hideyuki Ujiie, Norihiro Yoshimoto, Ken Natsuga, Ken Muramatsu, Hiroaki Iwata, Wataru Nishie, Hiroshi Shimizu   +6 more
doaj   +2 more sources

Identification of a human type XVII collagen fragment with high capacity for maintaining skin health [PDF]

Synthetic and Systems Biotechnology
Collagen XVII (COL17) is a transmembrane protein that mediates skin homeostasis. Due to expression of full length collagen was hard to achieve in microorganisms, arising the needs for selection of collagen fragments with desired functions for microbial ...
Xinglong Wang, Shuyao Yu, Ruoxi Sun, Kangjie Xu, Kun Wang, Ruiyan Wang, Junli Zhang, Wenwen Tao, Shangyang Yu, Kai Linghu, Xinyi Zhao, Jingwen Zhou   +11 more
doaj   +2 more sources

Mesenchymal stem cell-derived exosomes promote scalp rejuvenation through type XVII collagen regulation via the miR-21-5p/DKK2/Wnt pathway [PDF]

Frontiers in Cell and Developmental Biology
BackgroundHair follicle aging is driven by COL17A1 proteolysis in hair follicle stem cells (HFSCs). Mesenchymal stem cell (MSC)-derived exosomes show promise in tissue regeneration, but their effects on COL17A1 and hair follicle aging remain unexplored ...
Shiyue Cui, Yuanyuan Huang, Duo Zeng, Jie Li, Chun Tang   +4 more
doaj   +2 more sources

Therapeutic potential of recombinant human collagen XVII in blue light-induced skin photoaging: preserving epidermal-dermal structural integrity and functional homeostasis [PDF]

Frontiers in Bioengineering and Biotechnology
BackgroundExcessive exposure to blue light (BL) contributes to skin photoaging by inducing oxidative stress, inflammation, extracellular matrix degradation, and disruption of epidermal-dermal integrity. Recombinant human type XVII collagen (rhCol17) is a
Xudong Wang, Xudong Wang, Xudong Wang, Linlin Zhang, Qiang Li, Junhong Ao, Xin Zhang, Xin Yang, Jijin Li, Shijia Sui, Ge Ge, Haitao Li, Rongya Yang   +12 more
doaj   +2 more sources

Bullous Pemphigoid Develops Independently of DAP12 [PDF]

Biomolecules
The adaptor molecule DNAX-activating protein of 12 kDa (DAP12) is broadly expressed in innate immune cells, but its role in autoimmunity remains unclear due to its dual regulatory functions.
Manuela Pigors, Sabrina Patzelt, Maëlys Brudey, Shirin Emtenani, Stanislav Khil’chenko, Mayumi Kamaguchi, Niklas Reichhelm, Melissa Parker, Katja Bieber, Ralf J. Ludwig, Enno Schmidt   +10 more
doaj   +2 more sources