Results 11 to 20 of about 23,489 (224)

Evaluation of Discoidin domain receptor 1 (DDR1) in junctional epithelial permeability and wound healing. [PDF]

J Periodontol
Abstract Background Epithelium is the periodontal first line of defense against microbes. Discoidin domain receptor 1 (DDR1) is a collagen receptor expressed in epithelium. Ddr1 knockout (Ddr1−/−) mice develop periodontitis‐like defects, including junctional epithelium (JE) downgrowth, bacterial invasion, and alveolar bone loss.
Zachariadou C, Doshi A, Tatakis DN, Foster BL.   +3 more
europepmc   +2 more sources

Collagens - structure, function and biosynthesis. [PDF]

, 2003
The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions.
Aigner, T, Gelse, K, Poschl, E
core   +1 more source

Type XVII Collagen is a Key Player in Tooth Enamel Formation [PDF]

The American Journal of Pathology, 2009
Inherited tooth enamel hypoplasia occurs due to mutations in genes that encode major enamel components. Enamel hypoplasia also has been reported in junctional epidermolysis bullosa, caused by mutations in the genes that encode type XVII collagen (COL17), a component of the epithelial-mesenchymal junction. To elucidate the pathological mechanisms of the
Takuya, Asaka, Masashi, Akiyama, Takanori, Domon, Wataru, Nishie, Ken, Natsuga, Yasuyuki, Fujita, Riichiro, Abe, Yoshimasa, Kitagawa, Hiroshi, Shimizu   +8 more
openaire   +2 more sources

Multigene Next-Generation Sequencing Panel Identifies Pathogenic Variants in Patients with Unknown Subtype of Epidermolysis Bullosa: Subclassification with Prognostic Implications [PDF]

, 2017
Purpose: Epidermolysis bullosa (EB), the prototype of heritable blistering diseases, is caused by mutations in as many as 19 distinct genes. In this study, we evaluated the molecular basis of EB in 93 families, many of them of unknown subtype. Methods:
Abiri, Maryam, Aghazadeh, Nessa, Bagherian, Hamideh, Barzegar, Mohammadreza, Fortina, Paolo, Hamid, Mohammad, Mahmoudi, Hamidreza, Norouz-zadeh, Sara, Saeidian, Amir Hossein, Sotoudeh, Soheila, Touati, Andrew, Uitto, Jouni, Vahidnezhad, Hassan, Youssefian, Leila, Zahabiyon, Mahla, Zeinali, Sirous   +15 more
core   +1 more source

Identification of two novel bullous pemphigoid- associated alleles, HLA-DQA1*05:05 and -DRB1*07:01, in Germans

Orphanet Journal of Rare Diseases, 2021
Bullous pemphigoid (BP) is the most common autoimmune skin blistering disease characterized by autoimmunity against the hemidesmosomal proteins BP180, type XVII collagen, and BP230. To elucidate the genetic basis of susceptibility to BP, we performed the
Christian Schwarm, Damian Gola, Maike M. Holtsche, Anabelle Dieterich, Anita Bhandari, Miriam Freitag, Peter Nürnberg, Mohammad Toliat, Wolfgang Lieb, Michael Wittig, André Franke, Margitta Worm, Michael Sticherling, Jan Ehrchen, Claudia Günther, Regine Gläser, Wiebke K. Peitsch, Miklós Sárdy, Rüdiger Eming, Michael Hertl, Sandrine Benoit, Matthias Goebeler, Claudia Pföhler, Manfred Kunz, Alexander Kreuter, Nina van Beek, Jeanette Erdmann, Hauke Busch, Detlef Zillikens, Christian D. Sadik, Misa Hirose, Inke R. König, Enno Schmidt, Saleh M. Ibrahim, German AIBD Study Group   +34 more
doaj   +1 more source

Type XVII collagen: Relevance of distinct epitopes, complement-independent effects, and association with neurological disorders in pemphigoid disorders

Frontiers in Immunology, 2022
Pemphigoid diseases (PD) are autoimmune skin blistering diseases characterized by autoantibodies directed against proteins of the cutaneous basement membrane zone (BMZ).
Bianca Opelka, Enno Schmidt, Enno Schmidt, Stephanie Goletz   +3 more
doaj   +1 more source

Oxidative stress, protein glycation and nutrition – interactions relevant to health and disease throughout the lifecycle [PDF]

, 2014
Protein glycation has been studied for over a century now and plays an important role in disease pathogenesis throughout the lifecycle. Strongly related to diabetic complications, glycation of Hb has become the gold standard method for diabetes diagnosis
American Diabetes, Antonis Vlassopoulos, Bhagwat, El-Salem, Emilie Combet, Hao, Hodge, Khaw, Koenig, Maillard, Malickova, Michael E. J. Lean, Monnier, Nicholl, Rothwell, Schmidt, Sell, Vlassara   +17 more
core   +3 more sources

Development of an ELISA for sensitive and specific detection of IgA autoantibodies against BP180 in pemphigoid diseases

Orphanet Journal of Rare Diseases, 2011
Background Pemphigoids are rare diseases associated with IgG, IgE and IgA autoantibodies against collagen XVII/BP180. An entity of the pemphigoid group is the lamina lucida-type of linear IgA disease (IgA pemphigoid) characterized by IgA autoantibodies ...
Kárpáti Sarolta, Hertl Michael, Hashimoto Takashi, Ishii Norito, Florea Florina, Schmidt Sabine, Csorba Kinga, Bruckner-Tuderman Leena, Nishie Wataru, Sitaru Cassian   +9 more
doaj   +1 more source

Comprehensive RNA sequencing in primary murine keratinocytes and fibroblasts identifies novel biomarkers and provides potential therapeutic targets for skin-related diseases

Cellular & Molecular Biology Letters, 2021
Background Keratinocytes and fibroblasts represent the major cell types in the epidermis and dermis of the skin and play a significant role in maintenance of skin homeostasis.
Tiancheng Wang, Zhenwei Zhou, Enjing Luo, Jinghong Zhong, Daqing Zhao, Haisi Dong, Baojin Yao   +6 more
doaj   +1 more source

When maize is not the first choice: advances in paleodietary studies in the Archaeological Site Río Doncellas (Jujuy, Argentina) [PDF]

, 2016
In this work we present new values of stable isotopes of carbon (δ13Cco and δ13Cap) and nitrogen (δ15N) measured in a sample of 13 human individuals found in the Río Doncellas Archaeological Site (Late Period or Regional Developments, ca. 1000 AD-1450 AD)
Killian Galván, Violeta Anahí, Panarello, Hector Osvaldo, Samec, Celeste Tamara   +2 more
core   +2 more sources