Results 191 to 200 of about 23,489 (224)
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Matrix Biology, 2010
The human COL17A1 gene encodes type XVII collagen (also known as the 180-kDa bullous pemphigoid antigen), an integral component of hemidesmosomes, attachment complexes providing integrity to the dermal-epidermal junction. Zebrafish, a useful model system to study skin development, displays fully developed hemidesmosomes at approximately 5 days post ...
Kim, Seong Hyun +7 more
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The human COL17A1 gene encodes type XVII collagen (also known as the 180-kDa bullous pemphigoid antigen), an integral component of hemidesmosomes, attachment complexes providing integrity to the dermal-epidermal junction. Zebrafish, a useful model system to study skin development, displays fully developed hemidesmosomes at approximately 5 days post ...
Kim, Seong Hyun +7 more
openaire +3 more sources
Journal of Dermatological Science, 2000
Bullous pemphigoid (BP) is an acquired autoimmune skin disease, and its target antigens are a 230 kDa plaque protein (BP230) and a 180 kDa transmembrane protein with interrupted collagenous domains (BP180, type XVII collagen), which localize at the hemidesmosome.
Y, Hata, Y, Fujii, K, Tsunoda, M, Amagai
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Bullous pemphigoid (BP) is an acquired autoimmune skin disease, and its target antigens are a 230 kDa plaque protein (BP230) and a 180 kDa transmembrane protein with interrupted collagenous domains (BP180, type XVII collagen), which localize at the hemidesmosome.
Y, Hata, Y, Fujii, K, Tsunoda, M, Amagai
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Pigmentation and melanocyte supply to the epidermis depend on type XVII collagen
Experimental Dermatology, 2014Genetic deficiency of type XVII collagen (C17), laminin-332 or type VII collagen causes epidermolysis bullosa (EB). Spontaneous correction of the deficiency, also known as revertant mosaicism, is caused by a second somatic mutation that restores protein expression resulting in clinically healthy (revertant) patches surrounded by fragile (mutant) skin ...
Gostynski, Antoni +5 more
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Discovery and Functional Characterization of a Recombinant Fragment of Human Collagen Type XVII
Journal of Agricultural and Food ChemistryCOL17A1 is predominantly expressed in skin epithelial cells and primarily localized within hemidesmosomes. It plays an essential role in epidermal-dermal attachment. Consequently, a recombinant human-like COL17A1 protein (rhCOL17) with low molecular weight and high biocompatibility presents a promising and competitive biomaterial. The aim of this study
Lianhua Piao +8 more
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Two type XVII collagen (BP180) mRNA transcripts in human keratinocytes: a long and a short form.
Clinical and experimental dermatology, 2000We have analysed BP180 mRNA expression in normal human keratinocytes. Here we report the presence in normal keratinocytes of two COL17A1 transcripts which differ by 0.6 kb in length. Both mRNAs hybridized on Northern blot with probes directed to sequences encoding intracellular and extracellular fragments of BP180.
Molnar, K +6 more
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BP180 (type XVII collagen) and its role in cutaneous biology and disease.
Advances in dermatology, 2003BP180 is a key component of the epidermal anchoring complex and functions to maintain adherence of the epidermis to the basement membrane. Structural studies have revealed that BP180 is a type II transmembrane protein with a long carboxy-terminal collagenous domain that projects into the extracellular region beneath the epidermal hemidesmosome.
Françoise, Van den Bergh +1 more
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Read-Through for Nonsense Mutations in Type XVII Collagen‒Deficient Junctional Epidermolysis Bullosa
Journal of Investigative Dermatology, 2022Cristina Has +7 more
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Type 2 chronic inflammatory diseases: targets, therapies and unmet needs
Nature Reviews Drug Discovery, 2023P V Kolkhir +2 more
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