Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes. [PDF]
, 2018 Basement membranes are extracellular matrices essential for embryonic development in animals. Peroxidasins are extracellular peroxidases implicated in the unique sulfilimine cross-links between type IV basement membrane collagens. Loss of function in the
Chisholm, Andrew D +3 more
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The Diagnosis and Blistering Mechanisms of Mucous Membrane Pemphigoid
Frontiers in Immunology, 2019 Mucous membrane pemphigoid (MMP) is a mucous membrane-dominated autoimmune subepithelial blistering disease that is caused by autoantibodies against various autoantigens in basement membrane zone (BMZ) proteins, including collagen XVII (COL17 ...
Mayumi Kamaguchi +2 more
doaj +1 more source
Type XVII collagen interacts with the aPKC‐PAR complex and maintains epidermal cell polarity [PDF]
Experimental Dermatology, 2020 AbstractType XVII collagen (COL17) is a transmembrane protein expressed in the basal epidermis. COL17 serves as a niche for epidermal stem cells, and although its reduction has been implicated in altering cell polarity and ageing of the epidermis, it is unknown how COL17 affects epidermal cell polarity.
Mika Watanabe +9 more
openaire +3 more sources
Chronic tendon pathology: molecular basis and therapeutic implications [PDF]
, 2005 Tendons are frequently affected by chronic pain or rupture. Many causative factors have been implicated in the pathology, which until relatively recently was under-researched and poorly understood.
Riley, GP
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Syntenin-1 is a promoter and prognostic marker of head and neck squamous cell carcinoma invasion and metastasis. [PDF]
, 2016 Metastasis represents a key factor associated with poor prognosis of head and neck squamous cell carcinoma (HNSC). However, the underlying molecular mechanisms remain largely unknown. In this study, our liquid chromatography with tandem mass spectrometry
Cheng, Siliangyu +5 more
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COL17A1 editing via homology-directed repair in junctional epidermolysis bullosa
Frontiers in Medicine, 2022 BackgroundEpidermolysis bullosa (EB), a severe genetic disorder characterized by blister formation in skin, is caused by mutations in genes encoding dermal-epidermal junction proteins that function to hold the skin layers together.
Igor Petković +14 more
doaj +1 more source
Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis [PDF]
, 2015 Peritoneal dialysis (PD) is a form of renal replacement therapy whose repeated use can alter dialytic function through induction of epithelial-mesenchymal transition (EMT) and fibrosis, eventually leading to PD discontinuation. The peritoneum from Cav1-/-
Enrique, Calvo +13 more
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Immunotherapy‐Related Cutaneous Toxicities in Melanoma: A Dermoscopic Perspective
JEADV Clinical Practice, EarlyView.Dermoscopy serves as a valuable tool in the everyday dermatological and oncological practice for melanoma patients, allowing for the prompt identification of immune‐related cutaneous toxicities and guiding clinicians toward appropriate therapeutic decisions.
Grażyna Kamińska‐Winciorek +3 more
wiley +1 more source
The cytokine milieu of bullous pemphigoid: Current and novel therapeutic targets
Frontiers in Medicine, 2023 Bullous pemphigoid (BP) is the most common autoimmune bullous disease, characterized by severe pruritus and skin blistering. The loss of tolerance against Collagen XVII, also referred to as BP180, is the main pathogenic event of BP, leading to production
Roberto Maglie +6 more
doaj +1 more source
IgE autoantibodies and their association with the disease activity and phenotype in Bullous Pemphigoid: a systematic review [PDF]
, 2017 Bullous Pemphigoid (BP) is the most common autoimmune skin disease of blistering character. The underlying pathophysiological mechanism involves an immune attack, usually by IgG class autoantibodies, on the autoantigen BP 180/BPAg2, which is a type XVII ...
Fairclough, Lucy C. +3 more
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