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Distribution of collagen XVII in the human brain
Brain Research, 2007 We have recently discovered collagen XVII to be present in neurons of the human central nervous system. Collagen XVII has previously been primarily studied in the field of dermatopathology since it is abundantly expressed in the skin, which, like the nervous system, is ectodermal in origin.
Irina Alafuzoff +2 more
exaly +5 more sources
, 2023 Type XVII collagen, also known as 180kD bullous pemphigoid antigen (BP180), is a type II transmembrane collagen. It is expressed in epithelial hemidesmosomes of skin, colonic mucosa, cornea, brain, kidney, and placenta and has a number of binding ...
M. Crespo-Bravo +3 more
exaly +3 more sources
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Dermatologic Clinics, 2010
Collagen XVII has been identified as having a role in inherited junctional epidermolysis bullosa non-Herlitz (JEB-other, MIM #226650). The role of collagen XVII in both autoimmune and genetic blistering disorders demonstrates its relevance to dermal-epidermal adhesion.
Cristina Has
exaly +3 more sources
Collagen XVII has been identified as having a role in inherited junctional epidermolysis bullosa non-Herlitz (JEB-other, MIM #226650). The role of collagen XVII in both autoimmune and genetic blistering disorders demonstrates its relevance to dermal-epidermal adhesion.
Cristina Has
exaly +3 more sources
Two major 5′-untranslated regions for type XVII collagen mRNA
Journal of Dermatological Science, 2006 Background: Type XVII collagen is an important structural component of keratinocyte hemidesmosomes and its functional loss in genetic or autoimmune disease results in blistering of the skin.
Hendri H Pas +2 more
exaly +2 more sources
Collagenous transmembrane proteins: collagen XVII as a prototype
Matrix Biology, 2003Collagenous transmembrane proteins are an emerging group of biologically versatile molecules which function as both cell surface receptors and matrix molecules. The seven group members have interesting structural similarities: they are integral membrane proteins in type II orientation and have one or more collagenous domains in the extracellular C ...
Franzke, Claus-Werner +3 more
openaire +3 more sources
Cloning of Hamster Type XVII Collagen cDNA, and Pathogenesis of Anti-Type XVII Collagen Antibody and Complement in Hamster Bullous Pemphigoid [PDF]
Journal of Investigative Dermatology, 2002 Bullous pemphigoid is an inflammatory subepidermal blistering skin disease associated with an IgG autoimmune response to the type XVII collagen. The immunopathologic features of bullous pemphigoid can be reproduced in mice by the passive transfer of anti-type XVII collagen antibodies.
Hiroshi Shinkai, Shinobu Imajoh-Ohmi
exaly +3 more sources
Collagen XVII expression correlates with the invasion and metastasis of colorectal cancer
Human Pathology, 2015Collagen XVII has a well-established role as an adhesion molecule and a cell surface receptor located in the type I hemidesmosome of stratified epithelia. Its ectodomain is constitutively shed from the cell surface and suggested to regulate the adhesion, migration, and signaling of cutaneous epithelial cells. Collagen XVII was not previously thought to
Kaisa Tasanen +2 more
exaly +4 more sources
Collagen XVII is expressed in human CNS neurons
Matrix Biology, 2006Type XVII collagen (collagen XVII) is a component of hemidesmosomes, which connect epithelial cells to the underlying basement membrane. Previously, an association has been suggested between neurological disorders and the skin disease bullous pemphigoid, where autoimmunity is directed against collagen XVII.
Seppänen, Allan +8 more
openaire +3 more sources