Results 171 to 180 of about 464,753 (192)
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Experimental Dermatology, 2012
Abstract: Antibodies, specific to murine DEC205, can be used to target antigens to dendritic cells. The immunodominant domain of human type XVII collagen, hNC16A, was fused to this antibody (DEC‐hNC16A) and was administered as expression plasmid by gene gun transfection with the aim of inducing tolerance to human type XVII collagen in a skin ...
Iris Gratz +2 more
exaly +3 more sources
Abstract: Antibodies, specific to murine DEC205, can be used to target antigens to dendritic cells. The immunodominant domain of human type XVII collagen, hNC16A, was fused to this antibody (DEC‐hNC16A) and was administered as expression plasmid by gene gun transfection with the aim of inducing tolerance to human type XVII collagen in a skin ...
Iris Gratz +2 more
exaly +3 more sources
Clinical and Experimental Dermatology, 2005
Collagen XVII, or BP180, is a collagenous transmembrane protein and a structural component of the dermoepidermal anchoring complex. Molecular studies reveal that it has a globular cytosolic amino-terminal domain and flexible-rod extracellular carboxyterminal domain. The extracellular portion of collagen XVII is constitutively shed from the cell surface
A M, Powell +3 more
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Collagen XVII, or BP180, is a collagenous transmembrane protein and a structural component of the dermoepidermal anchoring complex. Molecular studies reveal that it has a globular cytosolic amino-terminal domain and flexible-rod extracellular carboxyterminal domain. The extracellular portion of collagen XVII is constitutively shed from the cell surface
A M, Powell +3 more
openaire +2 more sources
Cancer Research, 2023
Abstract Background: Collagens are the main components of the desmoplastic reaction of the tumors stroma, resulting in tumors fibrosis. Immuno-oncology (IO) is a central part of treating and understanding solid tumor patients. Alterations in the extracellular matrix (ECM) are known to contribute to tumor progression and metastasis ...
Marina Crespo-Bravo +4 more
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Abstract Background: Collagens are the main components of the desmoplastic reaction of the tumors stroma, resulting in tumors fibrosis. Immuno-oncology (IO) is a central part of treating and understanding solid tumor patients. Alterations in the extracellular matrix (ECM) are known to contribute to tumor progression and metastasis ...
Marina Crespo-Bravo +4 more
openaire +1 more source
Transmembrane collagen XVII is a novel component of the glomerular filtration barrier
Cell and Tissue Research, 2012The kidney filtration barrier consists of the capillary endothelium, the glomerular basement membrane and the slit diaphragm localized between foot processes of neighbouring podocytes. We report that collagen XVII, a transmembrane molecule known to be required for epithelial adhesion, is expressed in podocytes of normal human and mouse kidneys and in ...
Hurskainen, Tiina +10 more
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Altered expression of collagen XVII in ameloblastomas and basal cell carcinomas
Journal of Oral Pathology & Medicine, 2001Abstract:Background: Collagen XVII (BP180) is an epithelial transmembrane protein, which presumably plays a role in cell migration and differentiation under both physiological and pathological conditions. Ameloblastoma, the most common odontogenic neoplasm, and basal cell carcinoma (BCC) of the skin exhibit similar growth patterns and share ...
M, Parikka +4 more
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Type XVII collagen and collagen-like molecules: related by more than a common motif
Seminars in Cell & Developmental Biology, 1996Abstract Historically, collagens have been defined as extracellular matrix structural proteins whose sequence is characterized by many repeats of a three amino acid unit, GLY-X-Y. However, the latter motif has been identified in certain domains of a number of other proteins including the C1q subunit of complement, the collectins, the asymmetric form ...
Susan B. Hopkinson, Jonathan C.R. Jones
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Collagen XVII/BP180 knockout mouse and its transgenic rescue using human collagen XVII cDNA
2006Collagen XVII (COL17, BP180, BPAG2) is a type II transmembrane protein associated with the hemidesmosome-anchoring fi lament complex in basal keratinocytes, which plays a pivotal role in dermal-epidermal adhesion. COL17 is defective in non-Herlitz junctional epidermolysis bullosa (EB) patients (nH-JEB), and is targeted by autoantibodies in patients ...
Nishie, W. +7 more
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Role of collagen XVII in migrating keratinocytes
Journal of Dermatological Science, 2013Wataru Nishie +3 more
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