Results 121 to 130 of about 197,604 (257)

Intralesional and topical treatments for Peyronie’s disease: a narrative review of current knowledge

Asian Journal of Andrology
Peyronie’s disease (PD) presents a multifaceted challenge in contemporary urological practice, marked by penile deformity, pain, and the potential for erectile dysfunction.
Antonio Minore, Loris Cacciatore, Fabrizio Presicce, Andrea Iannuzzi, Antonio Testa, Gianluigi Raso, Rocco Papalia, Marco Martini, Roberto Mario Scarpa, Francesco Esperto   +9 more
doaj   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Investigation of antioxidant, anti collagenase, anti-elastase, and anti-hyaluronidase activities of Solanum trilobatum L. for pharmaceutical development

Journal of Advanced Pharmaceutical Technology & Research
The health and beauty sectors are significant drivers for the continuous growth of related product markets. Solanum trilobatum L. (S. trilobatum), locally known as Ma Waeng Krue, is a popular medicinal plant utilized in primary health care in Thailand ...
Chanai Noysang, Monsicha Khuanekkaphan, Teerarat Pummarin, Wiphupat Buranasukhon, Em-on Chaiprateep   +4 more
doaj   +1 more source

Collagenase-Induced Osteoarthritis in Mice.

, 2023
The collagenase-induced experimental osteoarthritis model is in general applied in mice but can also be used in other small species. The model is mainly based on the induction of joint laxity but has also a major inflammatory component.
Kraan, P.M. van der
core  

UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression

Advanced Science, EarlyView.
UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma, Rui Wan, Yueyuan Zhong, Ziyang Cui, Xuan Zhang, Xiaoqiang He, Rong Wang, Lei Huang, Wan‐Yang Sun, Rong‐Rong He, Yang Zhou, Jianshuang Li, Li Shen, Shao‐Hua Wang, Tongzheng Liu   +14 more
wiley   +1 more source

Inhibitors of Bacterial Collagenase [PDF]

, 1985
This invention relates to amino acid derivatives that are useful as inhibitors of bacterial collagenase. . .
Galardy, Richard E., Grobelny, Damian
core   +1 more source

Screening of a Plant Extract Library from the Greek Flora for Biological Activities Related to Anti-Aging Applications

Antioxidants
Characteristic manifestations of skin aging, due to either intrinsic or extrinsic factors, such as ultraviolet (UV) radiation and oxidative stress, include cell senescence, alterations in collagen and elastin networks, and melanogenesis disorders ...
Harris Pratsinis, Despoina D. Gianniou, Gabriela Belén Lemus Ringele, Adamantia Agalou, Asimina Fotopoulou, Xanthippi P. Louka, Christos Nastos, Eleftherios Kalpoutzakis, Aikaterini Argyropoulou, Dimitris Michailidis, Antonia Theodoridi, Ioanna Eleftheriadou, Adamantia Papadopoulou, Sentiljana Gumeni, Stavros Beteinakis, Konstantina Karamanou, Eleni Mavrogonatou, Georgios Stavropoulos, Dimitris Beis, Maria Halabalaki, Ioannis P. Trougakos, Dimitris Kletsas   +21 more
doaj   +1 more source

Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source